A review on Hydroxamic Acids: Widespectrum Chemotherapeutic Agents

Abstract

<jats:p>In accordance with the recommendations of The International Council for Standardization in Haematology (ICSH, https://icsh.org/), this article describes the morphophysiological characteristics of the precursors and mature erythroid cells in the early period of postnatal development of birds (Gallus gallus L.) including calculation of the surface area of these cells (S, μm2 , X±SEM). Depending on cell shape, cytoplasm color, and chromatin organization in nucleus, the following types are distinguished: basophilic erythroblasts (69.60±4.01 μm2 , p≤0.05), polychromatophilic erythroblasts (65.42±2.49 μm2 , p≤0.05), and oxyphilic erythroblasts (71.10±4.43 μm2). Formation of cell pool is characteristic for erythropoiesis in birds due to mitotic proliferation of basophilic erythroblasts. There are often proerythroblasts and polychromatophilic erythroblasts. The nucleus of a polychromatophilic proerythroblast contains a large number of histone proteins; therefore, it has an intensely basophilic color with a pronounced oxyphilic hue (proteinrelated oxyphilia). The accumulation of hemoglobin in the protoplasm of these cells contributes to the gradual transition of the basophilic staining of cytoplasm to the oxyphilic one which is typical for mature red blood cells (73.95±2.10 μm2 , p≤0.05). Cell shape and the structure of erythroblast nucleus approaches to these of mature red blood cells.</jats:p>

Toxicity and anti-tumour activity of organotin (IV) compounds

“…Several naturally occurring acids and the synthesis of a number of medicinally active hydroxylamine derivatives has been reported in recent years while some of the hydroxamic acids have already found applications in drug-delivery system 24,25 in iron-solubilisation and transport 26 and in DNA cleavage. [27][28][29] Studies regarding antitumour applications of the organotin are still not enough to have complete understanding of the mechanism.…”

Crystal Structures of a Series of Hydroxamic Acids

“…They act as potent and selective inhibitors of a large number of enzymes, such as matrix metalloproteinases, peroxidases, hydrolases, ureases, lipoxygenases, cyclooxygenases, histone deacetylases, and peptide deformylases [2]. HA are reported to possess anti-inflammatory, anti-tubercular, anti-leukemic, anti-microbial, and tumor-inhibiting properties [3]. They perform important roles in the manufacturing of various biologically active drugs, such as anti-depressants, anti-tumor agents, anti-HIV agents, and anti-malarial agents, and are also used in industries as insecticides, antioxidants, as inhibitors of corrosion, and for the extraction of toxic elements [3].…”

“…HA are reported to possess anti-inflammatory, anti-tubercular, anti-leukemic, anti-microbial, and tumor-inhibiting properties [3]. They perform important roles in the manufacturing of various biologically active drugs, such as anti-depressants, anti-tumor agents, anti-HIV agents, and anti-malarial agents, and are also used in industries as insecticides, antioxidants, as inhibitors of corrosion, and for the extraction of toxic elements [3].…”

“…The first hydroxamic acid (HA) was discovered by Lossen in 1869 (namely, oxalohydroxamic acid: HONH-CO-CO-NHOH). Since then, intensive work has focused on their reactions, structures [1], and biological activities [2,3]. The actual or predominant structures of HA are generally difficult to determine due to phenomena, such as polymorphism, stereoisomerism and tautomerism.…”

UV Laser-Induced Photodecomposition of Matrix-Isolated Salicylhydroxamic Acid: Identification of New Isocyanate Complexes

“…It also acts as an efficient ligand in mixed ternary complexes with ribonucleotides and metal (II) ions [5,6]. In addition, the antibacterial properties of SHA and its halogenated derivatives, which showed anti-tuberculosis activity in in vivo and in vitro tests, have been investigated [7,8]. SHA and its metal complexes have also shown antifungal or antiparasitic activity [9].…”