A review on hydrogen sulfide: Is it pro-nociceptive  or anti-nociceptive?

Eken, Hazal; Türkmen, Nurcan Bektaş; Arslan, Rana

doi:10.26650/istanbuljpharm.2022.913936

Cited by 2 publications

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“…Hydrogen sulfide, a toxic gas that acts by concentration changes, is an efficient gasotransmitter in the modulation of ionic channels and nociceptive receptors. Hydrogen sulfide is pronociceptive in its interaction with Ca v 3.2 channels and TRPA1 channels and is antinociceptive when it acts on potassium channels and opioid receptors ( Domoto et al, 2021 ; Eken et al, 2022 ). Hydrogen sulfide acts directly through sulfidation and redox modulation in Ca v 3.2 with an interaction site on the histidine H191 residue ( Peers et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions

Rangel‐Galván

Rangel-Galván²,

Rangel-Huerta

2023

Front. Pharmacol.

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Neuropathic pain can appear as a direct or indirect nerve damage lesion or disease that affects the somatosensory nervous system. If the neurons are damaged or indirectly stimulated, immune cells contribute significantly to inflammatory and neuropathic pain. After nerve injury, peripheral macrophages/spinal microglia accumulate around damaged neurons, producing endogenous hydrogen sulfide (H2S) through the cystathionine-γ-lyase (CSE) enzyme. H2S has a pronociceptive modulation on the Cav3.2 subtype, the predominant Cav3 isoform involved in pain processes. The present review provides relevant information about H2S modulation on the Cav3.2 T-type channels in neuropathic pain conditions. We have discussed that the dual effect of H2S on T-type channels is concentration-dependent, that is, an inhibitory effect is seen at low concentrations of 10 µM and an augmentation effect on T-current at 100 µM. The modulation mechanism of the Cav3.2 channel by H2S involves the direct participation of the redox/Zn2+ affinity site located in the His191 in the extracellular loop of domain I of the channel, involving a group of extracellular cysteines, comprising C114, C123, C128, and C1333, that can modify the local redox environment. The indirect interaction pathways involve the regulation of the Cav3.2 channel through cytokines, kinases, and post-translational regulators of channel expression. The findings conclude that the CSE/H2S/Cav3.2 pathway could be a promising therapeutic target for neuropathic pain disorders.

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Section: Introductionmentioning

confidence: 99%

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions

Rangel‐Galván

Rangel-Galván²,

Rangel-Huerta

2023

Front. Pharmacol.

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“…H 2 S can influence the activity of various ion channels, including calcium [76], potassium [77], and TRP channels [78], thus modulating intracellular signaling pathways linked to inflammation [79].…”

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confidence: 99%

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

Munteanu,

Iordan,

Hoteteu

et al. 2023

IJMS

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In the rapidly evolving field of Alzheimer’s Disease (AD) research, the intricate role of Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both pathological substrates and prospective therapeutic paradigms. While conventional pathophysiological models of AD have primarily emphasized the significance of amyloid-beta (Aβ) deposition and tau protein hyperphosphorylation, this targeted systematic review meticulously aggregates and rigorously appraises seminal contributions from the past year elucidating the complex mechanisms of H2S in AD pathogenesis. Current scholarly literature accentuates H2S’s dual role, delineating its regulatory functions in critical cellular processes—such as neurotransmission, inflammation, and oxidative stress homeostasis—while concurrently highlighting its disruptive impact on quintessential AD biomarkers. Moreover, this review illuminates the nuanced mechanistic intimate interactions of H2S in cerebrovascular and cardiovascular pathology associated with AD, thereby exploring avant-garde therapeutic modalities, including sulfurous mineral water inhalations and mud therapy. By emphasizing the potential for therapeutic modulation of H2S via both donors and inhibitors, this review accentuates the imperative for future research endeavors to deepen our understanding, thereby potentially advancing novel diagnostic and therapeutic strategies in AD.

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A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

Cited by 2 publications

References 0 publications

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

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