“…1 In addition to impaired cell-mediated immunity, comorbidities and immunosuppressive medications have a significant role in the development of fungal infections and have serious impacts on clinical outcomes. [1][2][3] Fungal infections of the central nervous system (CNS) are presented in different clinical syndromes and compared to other CNS infections, have a higher risk of morbidity and mortality. 4,5 In healthy individuals, CNS has functional and anatomical barriers to provide resistance against fungal infections and T lymphocytes play a key role in the immune surveillance of CNS.…”