Information Technology (IT) usage in university campuses consumes an enormous amount of power and incurs other costs in cooling and related operations. Currently, universities are infusing environmentally friendly initiatives in their campuses. However, IT professionals in most universities are not still sure how to infuse and assimilate environmentally friendly practices. Hence, green Information Systems (IS) are suggested for the utilization of technologies and systems in a greener and more sustainable planet. Accordingly, this study provides a review of existing green IS practices and further proposes a decision support framework based on Case Based Reasoning (CBR) technique. The proposed framework utilizes CBR to support the decision making of IT professionals in infusing and assimilating green IS within university campuses. Findings of this study show how the framework utilizes CBR to support IT professionals in assimilating green IS lifecycle and infusing green IS determinants. Furthermore, they show how IT professionals can green their university campuses. Moreover, this research study would be of interest to data and knowledge management community as well as environmental scientists and sustainability researchers.