A review on genotoxicity in connection to infertility and cancer

Choudhuri, Sharmistha; Kaur, Taruneet; Jain, Sapna; Sharma, Chandresh; Asthana, Shailendra

doi:10.1016/j.cbi.2021.109531

Cited by 24 publications

(9 citation statements)

References 146 publications

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“…Genotoxicity, one of the mechanisms of cancer formation, is also shown among the mechanisms of action of some drugs used in cancer treatment . Therefore, within the scope of this study, it was aimed to predict possible anticancer action mechanisms by evaluating the effects of EPI-loaded Fmoc-FF dipeptide structures on the genotoxic effect in neuroblastoma cells.…”

Section: Resultsmentioning

confidence: 99%

“…Genotoxicity, one of the mechanisms of cancer formation, is also shown among the mechanisms of action of some drugs used in cancer treatment. 42 Therefore, within the scope of this study, it was aimed to predict possible anticancer action mechanisms by evaluating the effects of EPI-loaded Fmoc-FF dipeptide structures on the genotoxic effect in neuroblastoma cells. For this purpose, when SH-SY5Y cells were exposed to dipeptides obtained other than the Fmoc-FF nanogel for 4, 24, and 72 h, it was determined that DNA damage increased depending on time and concentration.…”

Section: T H I S C O N T E N T Imentioning

confidence: 99%

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Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Erdoğan

Karayavuz

Bacanlı

et al. 2023

ACS Appl. Nano Mater.

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The control of the release behavior of a drug by an external stimulus, controllability from outside the body, reduced toxicity, and other side effects can provide benefits in delivery systems used in cancer treatment. However, the preparation and development of systems that control the dosage of the periodically released drug by an external stimulus are still a clinically needed approach. Here, we developed near-infrared (NIR) laser-enabled peptide nanogel systems by preparing Fmoc-diphenylalanine (Fmoc-FF) nanogels with a simple dispersion approach and preparing gold nanoparticles (AuNPs) decorated or gold nanostars (AuNSs) embedded in this system. The morphological properties and sizes of the prepared AuNS-embedded and AuNP-decorated Fmoc-FF nanogels were investigated by dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) methods. Structural and thermal characterizations were performed with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC), respectively. Epirubicin (EPI) release behaviors of the prepared AuNS-embedded and AuNP-decorated Fmoc-FF nanogels were investigated under 808 nm NIR laser irradiation. In vitro cytotoxicity and genotoxicity behaviors of the prepared particles were examined, and their effects on laser control release behaviors were also evaluated. It has been observed that EPI release can be controlled by laser irradiation in nanogels containing embedded or decorated plasmonic gold nanoparticles. In addition, it is understood from the in vitro results that the prepared nanogel systems are more effective synergistically under 808 NIR laser irradiation. Our results showed that Fmoc-FF peptide nanogel systems prepared as plasmonic AuNP embedded or decorated have great potential for controlled drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: T H I S C O N T E N T Imentioning

confidence: 99%

Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Erdoğan

Karayavuz

Bacanlı

et al. 2023

ACS Appl. Nano Mater.

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“…Nanoparticles cause variations in Mitotic Index as well as some mitotic and chromosomal abnormalities in dividing cells. The abnormalities in chromosome number and/or structure result from mechanisms such as DNA breaks, inhibition of DNA synthesis, errors in DNA replication, inhibition of RNA and protein synthesis, affected mitotic strands, and irregular separation of chromosomes (Choudhuri et al, 2021). Researchers argued that examining all phases would give more reliable results with the consideration that chromosomal abnormalities might occur in all phases of the cell cycle (Fiskesjö, 1985).…”

Section: Discussionmentioning

confidence: 99%

Genotoxic effect of iron oxide (Fe₂O₃) nanoparticles on Triticum aestivum (wheat)

Taşar

2023

Microscopy Res & Technique

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Industrial activities and unconscious consumption of natural resources cause environmental pollution with the rapid increase in the world population. As a result of the widespread use of iron oxide nanoparticles (Fe2O3 NP) with nano‐industrial activities, it is predicted that this NP will accumulate in the air, water, and soil. In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x‐ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. All concentrations of Fe2O3 NP caused significant decreases in the mitotic index. Fe2O3 NPs significantly increased the frequency of mitotic abnormalities in T. aestivum root tip cells at all treatment times and all concentrations when compared to the control. Fe2O3 NPs were formed by various mitotic abnormalities such as loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C‐Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star anaphase, multipolarity, and deconstructed telophase. All these results show that Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage. Briefly, these data show that Fe2O3 NPs taken by organisms may pose a danger to the organism and the upper consumer. These findings also show that the production and use of Fe2O3 NPs, which affect organisms, must be controlled, and ultimately, be safely disposed of to reduce their bioaccumulation. Research Highlights In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. (bread wheat) plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x‐ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. The mitotic index was calculated to reveal the genotoxic effect. “Loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C‐Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star Chromosomal abnormalities such as anaphase, multipolarity, and deconstructed telophase” were visualized. Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage.

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“…They promote impaired activation, synthesis, and secretion of endogenous hormones, thus influencing several hormonal and metabolic processes [ 38 , 40 ]. Moreover, some EDCs show genotoxic effects [ 41 , 42 ] and perturb the epigenetic landscape, inducing alterations of target cells [ 43 , 44 ]. A number of clinical and experimental studies have shown the impact of EDCs on human GM [ 45 ].…”

Section: The Dangerous Effects Of Endocrine-disrupting Chemicals On T...mentioning

confidence: 99%

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

Fabozzi

Rebuzzini

Cimadomo

et al. 2022

Cells

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The gut microbiota (GM) is a complex and dynamic population of microorganisms living in the human gastrointestinal tract that play an important role in human health and diseases. Recent evidence suggests a strong direct or indirect correlation between GM and both male and female fertility: on the one hand, GM is involved in the regulation of sex hormone levels and in the preservation of the blood–testis barrier integrity; on the other hand, a dysbiotic GM is linked to the onset of pro-inflammatory conditions such as endometriosis or PCOS, which are often associated with infertility. Exposure to endocrine-disrupting chemicals (EDCs) is one of the main causes of GM dysbiosis, with important consequences to the host health and potential transgenerational effects. This perspective article aims to show that the negative effects of EDCs on reproduction are in part due to a dysbiotic GM. We will highlight (i) the link between GM and male and female fertility; (ii) the mechanisms of interaction between EDCs and GM; and (iii) the importance of the maternal–fetal GM axis for offspring growth and development.

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A review on genotoxicity in connection to infertility and cancer

Cited by 24 publications

References 146 publications

Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Genotoxic effect of iron oxide (Fe₂O₃) nanoparticles on Triticum aestivum (wheat)

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

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A review on genotoxicity in connection to infertility and cancer

Cited by 24 publications

References 146 publications

Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Low-Molecular-Weight Dipeptide Nanogel Containing Plasmonic Gold Nanoparticles for Drug Release Applications

Genotoxic effect of iron oxide (Fe2O3) nanoparticles on Triticum aestivum (wheat)

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

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Genotoxic effect of iron oxide (Fe₂O₃) nanoparticles on Triticum aestivum (wheat)