A Review on General Overview About Diabetes Mellitus

Dodia, Richa Virendrasinh; Sahoo, Susmita

doi:10.54105/ijapsr.b4005.121321

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Long-term harm, dysfunction, and failure of numerous organs, including the kidneys, heart, blood vessels, brain, and nerves, are associated with DM's persistent hyperglycemia. The main reasons for inadequate insulin action include insufficient insulin secretion and/or diminished tissue responsiveness to insulin at one or more sites in the hormonal action chain [3]. Type 1 DM is insulin-dependent.…”

Section: Introductionmentioning

confidence: 99%

Effective Treatment of Diabetes Mellitus by Resonance Medicine

Jalan¹,

Anjankar²,

Deshpande³

2022

Cureus

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The metabolic disorder known as diabetes mellitus (DM) has several different causes, distinguished by recurring hyperglycemia due to inadequate insulin secretion, insulin action, or both. T-lymphocytes target such cells for destruction, which include beta cells. Transplants of the pancreas, islets of Langerhans, and individual beta cells are all effective treatments for DM. Additionally, treating DM using stem cells is popular currently. The basis of stem cell therapy for DM is the replacement of beta cells, or dead pancreatic cells, with stem cells. After attaching to the tissues of the pancreas, the stem cells differentiate into active cells. An X-ray scanner is used to place a catheter into the pancreatic artery in DM, and the process lasts 90 minutes. The use of stem cells to replace dead pancreatic beta cells forms the cornerstone of stem cell treatment for DM. Transplants of the pancreas, islets of Langerhans, and individual beta cells are all effective treatments for insulin-dependent DM.In contrast to prior studies, where we only used low potencies of nosodes and organopreparations, our research used both high and low potencies of these substances. Choosing the strength of the nosode stomach cancer in the computer-connected device selector so that it will resonate with the nosode that is tested in the patient's device is the doctor's responsibility when using the bioresonance therapy method. The initial nosode, which is in the computer programme of the device for bioresonance therapy, is no longer tested when the stomach cancer nosode is tested in a patient along with the chosen potency of this nosode. The initial nosode in the bioresonance therapy device itself is still being studied in case the chosen nosode's potency is inadequate (the frequency of oscillations of the nosode is lower than the frequency of oscillations of the tumour).

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Section: Introductionmentioning

confidence: 99%

Effective Treatment of Diabetes Mellitus by Resonance Medicine

Jalan¹,

Anjankar²,

Deshpande³

2022

Cureus

View full text Add to dashboard Cite

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Formulation and Evaluation of Metformin Using Fenugreek Seed Mucilage Used as a Natural Polymer

Gupta

2024

IJAPSR

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The major goal of this study was to develop and test metformin sustained release tablets employing fenugreek seed mucilage (FSM) as a new binder, as opposed to standard polymers such as xanthan gum and HPMC. The study shows how FSM provides sustained medication release while keeping metformin physicochemical characteristics. The sustained-release matrix tablets were made on a laboratory scale utilizing the wet granulation process. 5 batches were created, each with varying quantities of fenugreek seed mucilage, xanthan gum, and HPMC. To examine the tablet's physical properties and consistency, different criteria such as thickness, hardness, weight variation, and content homogeneity were measured. FTIR tests were performed to determine the compatibility of metformin and the polymers employed. The results showed no incompatibility, indicating that the novel excipient, FSM was not affecting the drug's physicochemical qualities. The in-vitro drug dissolution investigation was conducted utilizing a USP type-II paddle apparatus to quantify the drug release rate from dosage forms and to assess thepolymers' efficacy in retarding drug release. The study discovered that raising the concentration ofthe matrix ingredient reduced the medication release rate. Among the formulations, the combination of FSM with HPMC (MS1) resulted in 95% drug release, FSM with xanthan gum achieved 96% drug release, and the MS4 formulation had the greatest drug release rate. Finally, the study showed that fenugreek seed mucilage and xanthan gum effectively develop metformin continuous-release matrix tablets. Lower concentrations of these polymers were more suited and effective, resulting in sustained drug release. This study demonstrates the potential of fenugreek seed mucilage as a novel and effective binder in sustained-release formulations.

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A Review on General Overview About Diabetes Mellitus

Abstract: Diabetes mellitus could also be a big issue nowadays. The approach to life and daily circumstances play the main part in this type of serious complication. Throughout this review, we get general information about the disease.

Cited by 2 publications

References 16 publications

Effective Treatment of Diabetes Mellitus by Resonance Medicine

Effective Treatment of Diabetes Mellitus by Resonance Medicine

Formulation and Evaluation of Metformin Using Fenugreek Seed Mucilage Used as a Natural Polymer

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