The present study was conducted to determine the appropriate inoculum dose and incubation period for the mixture of Cassava Leaf Meal (CLM) and Tofu Dreg (TD) fermented with Rhizopus oligosporus. This experiment was carried out in a completely randomized design in a 3 x 4 factorial treatments arrangement with 4 replications. The first factor was the inoculum dose (6, 8 and 10%), and the second factor was the incubation period of the fermentation (2, 3, 4, and 5 days). Measured variables were the changes in Dry Matter (DM), Organic Matter (OM), crude fat, Crude Fiber (CF), and Crude Protein (CP). The experimental results showed that there was no interaction between the inoculum dose and an incubation period of the fermentation in the reduction of DM, organic matter, and crude fat as well as the increase in the CP of fermented CLM and TD with Rhizopus oligosporus. However, the interaction was occurred between inoculum dose and incubation period in the reduction in CF. The inoculum dose significantly decreased the DM, OM, crude fat and CF and also increased the CP. The best inoculum dose effect was at 10%. The incubation period had a significant reduction in the DM, OM, crude fat, and CF and also increased the CP. The best incubation period of fermentation was at 3 days. The results indicated that the appropriate inoculum dose to ferment CLM and TD mixture with Rhizopus oligosporus was 10% at each incubation period. In the meanwhile, the appropriate incubation period was 3 days for each inoculum dose.