A Review on Formulation and Characterization of Herbosome Complex

Abstract

The major amount of active constituents comprises in herbal drugs with excellent bioactivity in vitro but less in vivo because of their poor lipid solubility and improper size of the molecules. This results in poor absorption and bioavailability of active constituents from the herbal extract. Herbosome technology enhances the bioavailability of herbal extracts. Herbosome act as the bridge between the novel delivery system and conventional delivery system. It is a complex of natural active ingredients and phospholipids (phosphatidylcholine, phosphatidylserine etc.) which increases absorption of herbal extract. Herbosome is the novel emerging technique applied to phytopharmaceuticals for the enhancement of bioavailability of herbal extract for medicinal applications. This article overviews about herbosome technology, recent advance, their application for various standardized herbal extracts and aims to provide complete scientific information, characterization about herbosomes as a promising drug delivery system.

Development and Characterization of Terminalia arjuna Phospholipid Complex and Its Tablet Formulation by Qbd Approach

“…27 Based on the above study it was concluded that the phytosome formulation of hydroalcoholic extract of Terminalia arjuna and its Tablet formulation improved the bioavailability and may be used as herbal formulation in the treatment of cardiovascular disease for antioxidant activity. 5,8 7.…”

“…4 Phytosomes is a newly introduced patented technology developed to incorporate the standardized plant extracts or water-soluble phytoconstituents into phospholipids to produce lipid compatible molecular complexes, which improves their absorption and bioavailability. 5,6,7 Phytosome technology has been effectively used to enhance the bioavailability of many popular herbal extracts including milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc and can be utilized for various therapeutic uses or for administration of dietary supplements. The flavonoid and terpenoids components of these herbal extracts lend themselves quite well for the direct binding to phosphatidylcholine.…”

A Novel Targeted Drug Delivery Carrier: Herbosomes

“…• Herbosomes are also used as an anti-inflammatory, lipolytic, isokinetic, antiedema, cicatrizing, trophodermic, nutraceutical immunomodulator, antioxidant for skin and liver, cardioprotective, anti-wrinkle, and UV protectant [7].…”

“…Transmission electron microscopy (TEM) can visualize herbosomes, revealing their internal composition and characteristics, such as morphology, crystallization, stress, and magnetic domains [7].…”

“…Phospholipids in herbosomes have proven health benefits and demonstrate better pharmacokinetic and pharmacodynamic profiles than conventional herbal extracts [6]. Traditional medicine systems, such as African, Chinese, and Indian systems, usually involve crude extracts of various herbs, which may contain unwanted and sometimes toxic principles and active ingredients [7]. Specific or groups of similar plant ingredients are extracted, isolated, and tested for their therapeutic properties using photo and analytical chemistry methods [8].…”