A review on fabrication of nanofibers via electrospinning and their applications

Islam, Shariful; Ang, Bee Chin; Andriyana, Andri; Afifi, Amalina M.

doi:10.1007/s42452-019-1288-4

Cited by 233 publications

(177 citation statements)

References 167 publications

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“…Similarly to muscle scaffolds, for enhanced nerve regeneration fibrous scaffolds of PLLA, PCL, PGA, etc. with aligned or random arrangements are commonly used [165]. Moreover, different studies demonstrated that therapeutic cell-laden scaffolds also enhanced in vivo soft tissue regeneration.…”

Section: Scaffolds For Soft Tissue Applicationmentioning

confidence: 99%

Recent advances in biomaterials for 3D scaffolds: A review

Nikolova

Chavali

2019

Bioactive Materials

648

442

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Considering the advantages and disadvantages of biomaterials used for the production of 3D scaffolds for tissue engineering, new strategies for designing advanced functional biomimetic structures have been reviewed. We offer a comprehensive summary of recent trends in development of single- (metal, ceramics and polymers), composite-type and cell-laden scaffolds that in addition to mechanical support, promote simultaneous tissue growth, and deliver different molecules (growth factors, cytokines, bioactive ions, genes, drugs, antibiotics, etc.) or cells with therapeutic or facilitating regeneration effect. The paper briefly focuses on divers 3D bioprinting constructs and the challenges they face. Based on their application in hard and soft tissue engineering, in vitro and in vivo effects triggered by the structural and biological functionalized biomaterials are underlined. The authors discuss the future outlook for the development of bioactive scaffolds that could pave the way for their successful imposing in clinical therapy.

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Section: Scaffolds For Soft Tissue Applicationmentioning

confidence: 99%

Recent advances in biomaterials for 3D scaffolds: A review

Nikolova

Chavali

2019

Bioactive Materials

648

442

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“…The electrospinning method represents a combination of solid dispersion technology and nanotechnology. In this method, solid fibers in the micro- or nanometer range are produced from a polymeric fluid stream or melt delivered through a millimeter-scale nozzle [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In the pharmaceutical field, electrospinning has recently gained high interest for the production of drug delivery systems based on nanofibers [ 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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Mats of polyvinyl alcohol (PVA) core–shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC) N4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core–shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. NMR spectroscopy and thermal analysis (TG/DTA) gave proof for the chemical integrity of the TSC in the fiber mats after the electrospinning process. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy showed no TSC on the surface of the PVA/TSC-PVA fibers confirming the core–shell character. The TSC release profiles of the fibers as studied using UV-vis absorption spectroscopy showed a slower release from the PVA/TSC-PVA core–shell structure compared with the monolithic PVA/TSC fibers as well as lower cumulative release percentage (17%). Out of several release models, the Korsmeyer–Peppas model gave the best fit to the experimental data. The main release phase can be described with a Fick-type diffusion mechanism. Antibacterial properties were tested against the Gram-positive Staphylococcus aureus bacterium and gave a minimal inhibitory concentration of 12.5 μg/mL. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT)-based cytotoxicity experiments showed that the cell viability of fibroblast at different contents of TSC was slightly decreased from 1.5% up to 3.5% when compared to control cells.

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“…Electrospun polymeric and nanocomposite nanofibers have promising potential for various technical applications. 71,72 Figure 10 shows application areas for polymeric and nanocomposite nanofibers. An important nanofiber application is in filtration membranes.…”

Section: Applications Of Electrospun Polymeric Nanocompositesmentioning

confidence: 99%

Polymeric nanocomposite via electrospinning: Assessment of morphology, physical properties and applications

Kausar

2020

Journal of Plastic Film & Sheeting

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Polymeric nanofibers have appeared as unique one-dimensional nanomaterials. Nanofibers possess exceptionally high specific surface area and essential properties. Various polymeric nanofibers and nanocomposite nanofibers have been developed using thermoplastic and thermosetting matrices and organic and inorganic nanoparticles. This review documents the worth of nanofiber technology regarding the synthesis, morphology, physical properties, and applications of the nanostructures. The nanofiber surface morphology and diameter directly influence the physical characteristics such as electrical conductivity, mechanical properties, and thermal stability. Fiber processing techniques and related parameters also affect their texture and properties. In this regard, electrospinning is frequently used to form polymeric nanofibers and nanocomposite nanofibers. Electrospun nanofibers having large surface area and excellent fiber orientation, alignment, and morphology. The polymer nanocomposites with different nanofillers (carbon nanotube, graphene, carbon nanofibers, and other nanoparticles) have been processed into high performance electrospun nanofibers. Electrospun nanomaterials have been applied in engineered structures, nanofibrous membranes, electronic devices, tissue engineering, drug delivery, antibacterial materials and other biomedical applications. Henceforth, this is a comprehensive review on physical characteristics, morphology, processing aspects, and application areas for polymeric and nanocomposite nanofibers.

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A review on fabrication of nanofibers via electrospinning and their applications

Cited by 233 publications

References 167 publications

Recent advances in biomaterials for 3D scaffolds: A review

Recent advances in biomaterials for 3D scaffolds: A review

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Polymeric nanocomposite via electrospinning: Assessment of morphology, physical properties and applications

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