A Review on ethnobotanical uses, biological activities and phytochemical aspects of Acacia senegal (L.) Willd. and Acacia seyal Delile. (Fabaceae)

Abstract

The genus Acacia is a group of tropical plants species used in folk medicine due to virtue of its many therapeutic properties. In this document, we review the Ethnopharmacology, biological and phytochemical activities of the two major plant species used. Although, several researchers has been done, Acacia senegal (L.) Willd. and Acacia seyal Delile. are among the species of the genus for which phytochemical study is limited, few bioactive compounds and properties described. Based on these current traditional uses, it is necessary to carry out more biochemical and pharmaceutical assays in order to identify the precise ingredient that supports the recommendation in traditional medicine. The characterization of the active compound that plays a role for treating human diseases (infection, cancer, etc.) represents a key step in phytochemical research of new compounds. Moreover, this information about the active compound will help the clinician/pharmacist to define a rational and combined use with the synthetic molecules for which resistance mechanisms are currently reported in clinical cases. Keywords: Acacia Senegal; Acacia seyal; Antimicrobial; Biological activity; Phytochemistry; Tradional medicine

Traditional Medicinal Plants as the Potential Adjuvant, Prophylactic and Treatment Therapy for COVID-19 Disease: A Review

“…A. senegal (Figure 2), also known as white gum tree, belongs to the Mimosoideae family of plants and is widely distributed in Senegal, Cameroon, and Sudan [26][27][28]. Exotic A. Senegal is found in South Africa and is called siKhambophane and umKhala in isiZulu [29].…”

“…Exotic A. Senegal is found in South Africa and is called siKhambophane and umKhala in isiZulu [29]. A. senegal is traditionally used to treat respiratory symptoms and infections, such as flu and sore throat (Table 1), and other conditions including, sinusitis, toothaches, stomach ulcer, colic, diarrhea, and dysentery [19,26]. This medicinal plant has pharmacological activities, which include anti-inflammatory, antibacterial, antifungal, and antioxidant [26].…”

“…A. senegal is traditionally used to treat respiratory symptoms and infections, such as flu and sore throat (Table 1), and other conditions including, sinusitis, toothaches, stomach ulcer, colic, diarrhea, and dysentery [19,26]. This medicinal plant has pharmacological activities, which include anti-inflammatory, antibacterial, antifungal, and antioxidant [26]. Secondary metabolites identified from A. senegal's plants extracts include glycosides, alkaloids, flavonoids, and arabic acid [15,19,26].…”

Acacia senegal Extract Rejuvenates the Activity of Phenicols on Selected Enterobacteriaceae Multi Drug Resistant Strains

“…Medicinal plants from the African continent have been previously studied for biological properties, and they exhibit interesting antibacterial activity [8]. Preclinical data on traditional uses show that A. senegal treats respiratory tract infections, diarrhea, stomach aches, hemorrhoids, ulcers, trypanosomiasis, sexually transmitted diseases, wounds, malaria, abscesses, and boils [9][10][11][12]. Another traditional healer treats dysentery, gastrointestinal pain, leprosy, nervous sensory and digestive disorders, toothache, rheumatism, stomach ulcers, jaundice, intestinal parasites, and syphilis by roots, leaves, barks, and gum of A. seyal [10,13,14].…”

“…Another traditional healer treats dysentery, gastrointestinal pain, leprosy, nervous sensory and digestive disorders, toothache, rheumatism, stomach ulcers, jaundice, intestinal parasites, and syphilis by roots, leaves, barks, and gum of A. seyal [10,13,14]. In recent studies, extracts of A. senegal and A. seyal have shown good activity against many agents responsible for infectious diseases [12,[15][16][17] and have interesting chemical components such as phenolic compounds, flavonoids, tannins, or terpenes recognized as having a strong antibacterial potential [8,18]. There is no study regarding possible adjuvant propriety of their extracts and their capability to permeabilize the bacterial membrane.…”