A review on enzyme complexes of electron transport chain from Mycobacterium tuberculosis as promising drug targets

Anand, Pragya; Akhter, Yusuf

doi:10.1016/j.ijbiomac.2022.05.124

Cited by 18 publications

(13 citation statements)

References 169 publications

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“…It kills more people than any other infectious disease of bacterial origin. The emergence and spread of multidrug-resistant, extensively drug-resistant, and totally drug-resistant strains of M. tuberculosis is a great challenge in anti-tuberculosis treatment [ 112 , 113 ]. Thus, there is an urgent need to create potent antimycobacterial agents with a novel mechanism of action.…”

Section: Mycobacterium Tuberculosis F 1 ∙...mentioning

confidence: 99%

F1·Fo ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis

Zharova

Grivennikova

Borisov

2023

IJMS

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F1·Fo-ATP synthases/ATPases (F1·Fo) are molecular machines that couple either ATP synthesis from ADP and phosphate or ATP hydrolysis to the consumption or production of a transmembrane electrochemical gradient of protons. Currently, in view of the spread of drug-resistant disease-causing strains, there is an increasing interest in F1·Fo as new targets for antimicrobial drugs, in particular, anti-tuberculosis drugs, and inhibitors of these membrane proteins are being considered in this capacity. However, the specific drug search is hampered by the complex mechanism of regulation of F1·Fo in bacteria, in particular, in mycobacteria: the enzyme efficiently synthesizes ATP, but is not capable of ATP hydrolysis. In this review, we consider the current state of the problem of “unidirectional” F1·Fo catalysis found in a wide range of bacterial F1·Fo and enzymes from other organisms, the understanding of which will be useful for developing a strategy for the search for new drugs that selectively disrupt the energy production of bacterial cells.

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Section: Mycobacterium Tuberculosis F 1 ∙...mentioning

confidence: 99%

F1·Fo ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis

Zharova

Grivennikova

Borisov

2023

IJMS

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“…Moreover, the tricarboxylic acid cycle and electron transport chain, which are key bacterial metabolic pathways, have a significant impact on bacterial productivity and respiration. 43 Additionally, metabolic-related proteins and metabolites can potentially reverse bacterial drug resistance. 44 Genes such as mdtG, 45 emeA, 46 and hlyD 47 are involved in the transcriptional regulation of the multidrug efflux pump system and membrane permeability.…”

Section: ■ Discussionmentioning

confidence: 99%

Analyses of the Antibiofilm Activity of o-Phenanthroline Monohydrate against Enterococcus faecalis and Staphylococcus aureus and the Mechanisms Underlying These Effects

Wang,

Wu,

Wang

et al. 2024

ACS Infect. Dis.

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Enterococcus faecalis and Staphylococcus aureus exhibit robust biofilm formation capabilities, the formation of which is closely linked to pathogenicity and drug resistance, thereby resulting in host infection and treatment failure. o-Phenanthroline monohydrate (o-Phen) and its derivatives demonstrate a wide range of antibacterial and antifungal activities. In this study, we aimed to explore the antibiofilm activity of o-Phen to E. faecalis and S. aureus and provide insights into the molecular mechanisms for combating biofilm resistance. We demonstrated that o-Phen possesses significant antibacterial and antibiofilm properties against E. faecalis and S. aureus, inducing alterations in bacterial morphology, compromising cell membrane integrity, and exhibiting synergistic effects with β-lactam antibiotics at sub-MIC concentrations. The adhesion ability and automatic condensation capacity of, and synthesis of, extracellular polymers by E. faecalis cells were reduced by o-Phen, resulting in the inhibition of biofilm formation. Importantly, transcriptome analysis revealed 354 upregulated and 456 downregulated genes in o-Phen-treated E. faecalis. Differentially expressed genes were enriched in 11 metabolism-related pathways, including amino acid metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis. Moreover, the oppA, CeuA, and ZnuB genes involved in the ABC transport system, and the PBP1A penicillin-binding protein-coding genes sarA and mrcA were significantly downregulated. The multidrug efflux pump system and membrane permeability genes mdtG and hlyD, and bacterial adhesion-related genes, including adcA and fss2 were also downregulated, while mraZ and ASP23 were upregulated. Thus, o-Phen is anticipated to be an effective alternative drug for the treatment of E. faecalis and S. aureus biofilm-associated infections.

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“…They contribute significantly to the ability of bacteria to resist stresses induced by peroxide [49,[112][113][114][115][116], sulfide [5,[117][118][119][120], ammonia [121], chromate [122], cyanide [117,123]. Due to the fact that the bd oxidases are often found in pathogenic bacteria but absent in humans, they can be used as protein targets for next-generation antimicrobials [43,64,68,[124][125][126][127][128][129][130][131][132][133][134].…”

Section: Bacterial Aerobic Respiratory Chainsmentioning

confidence: 99%

Bioenergetics and Reactive Nitrogen Species in Bacteria

Borisov

Forte

2022

IJMS

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The production of reactive nitrogen species (RNS) by the innate immune system is part of the host's defense against invading pathogenic bacteria. In this review, we summarize recent studies on the molecular basis of the effects of nitric oxide and peroxynitrite on microbial respiration and energy conservation. We discuss possible molecular mechanisms underlying RNS resistance in bacteria mediated by unique respiratory oxygen reductases, the mycobacterial bcc-aa3 supercomplex, and bd-type cytochromes. A complete picture of the impact of RNS on microbial bioenergetics is not yet available. However, this research area is developing very rapidly, and the knowledge gained should help us develop new methods of treating infectious diseases.

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A review on enzyme complexes of electron transport chain from Mycobacterium tuberculosis as promising drug targets

Cited by 18 publications

References 169 publications

F1·Fo ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis

F1·Fo ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis

Analyses of the Antibiofilm Activity of o-Phenanthroline Monohydrate against Enterococcus faecalis and Staphylococcus aureus and the Mechanisms Underlying These Effects

Bioenergetics and Reactive Nitrogen Species in Bacteria

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