A review on EBV encoded and EBV-induced host microRNAs expression profile in different lymphoma types

Soltani, Saber; Zakeri, Armin; Tabibzadeh, Alireza; Zakeri, Amir Mohammad; Zandi, Milad; Siavoshi, Saba; Seifpour, Saba; Farahani, Abbas

doi:10.1007/s11033-021-06152-z

Cited by 14 publications

(13 citation statements)

References 61 publications

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“…25 In these particular cases, detection of EBV-encoded viral and host miRNAs could be indicative to be performed in highly clinical susceptible cases. 26 Hence, considering LMP-1 IHC as a standard diagnostic method for the EBV-associated HL and comparing it with the results obtained from DNA detection method, this study showed that the quantitative detection of plasma EBV DNA was very sensitive and specific. Therefore, it could serve as a promising and convenient detection tool for the EBVassociated HL cases.…”

Section: Discussionmentioning

confidence: 83%

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Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

et al. 2021

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Objectives: Epstein–Barr virus is a tumorigenic virus and has been extensively studied as a causative agent for Hodgkin lymphoma. Although immunostaining of the tumor biopsy is the standard method for diagnosis of Epstein–Barr virus-driven Hodgkin lymphoma, the invasiveness of the procedure renders it difficult and less desirable for the patients. Therefore, we designed this study to evaluate the efficiency of plasma Epstein–Barr virus DNA detection as an alternative diagnostic and prognostic method for Epstein–Barr virus–associated Hodgkin lymphoma. Methods: This analytical cross-sectional study was conducted during March 2017 to December 2018 including 43 Hodgkin lymphoma patients diagnosed histopathologically followed by the latent membrane protein-1 immunohistochemistry to determine their Epstein–Barr virus association. Plasma Epstein–Barr virus DNA in these samples was measured using quantitative polymerase chain reaction (qPCR). Results: Of total, 29 (67.44%) patients tested positive for plasma Epstein–Barr virus DNA. On comparing results of latent membrane protein-1 immunohistochemistry (IHC) with plasma Epstein–Barr virus DNA, plasma Epstein–Barr virus DNA was found in 25 of 30 patients with latent membrane protein-1 expression and 4 of 13 patients without latent membrane protein-1 expression. The sensitivity and the specificity of plasma Epstein–Barr virus DNA detection with respect to latent membrane protein-1 IHC were found to be 83.33% and 69.23%, respectively ( p = 0.0014). Conclusion: Determination of plasma Epstein–Barr virus DNA was found to be highly sensitive and specific in characterizing Epstein–Barr virus–associated Hodgkin lymphoma, suggesting that this diagnostic method holds promise as an alternative and more convenient method of diagnosis compared with tissue biopsy.

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Section: Discussionmentioning

confidence: 83%

“… 25 In these particular cases, detection of EBV-encoded viral and host miRNAs could be indicative to be performed in highly clinical susceptible cases. 26 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

et al. 2021

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“…EBV life cycle is strictly linked to the human antiviral mechanisms, particularly through exploitation of its microRNA fine-tuning. For example, BART20-5P inhibits IFN-γ while EBV-miR-8 inhibits STAT1 [114].…”

Section: Oncogenic Herpesvirusesmentioning

confidence: 99%

Virus-Induced Tumorigenesis and IFN System

Iuliano

Mangino

Chiantore

et al. 2021

Biology

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Oncogenic viruses favor the development of tumors in mammals by persistent infection and specific cellular pathways modifications by deregulating cell proliferation and inhibiting apoptosis. They counteract the cellular antiviral defense through viral proteins as well as specific cellular effectors involved in virus-induced tumorigenesis. Type I interferons (IFNs) are a family of cytokines critical not only for viral interference but also for their broad range of properties that go beyond the antiviral action. In fact, they can inhibit cell proliferation and modulate differentiation, apoptosis, and migration. However, their principal role is to regulate the development and activity of most effector cells of the innate and adaptive immune responses. Various are the mechanisms by which IFNs exert their effects on immune cells. They can act directly, through IFN receptor triggering, or indirectly by the induction of chemokines, the secretion of further cytokines, or by the stimulation of cells useful for the activation of particular immune cells. All the properties of IFNs are crucial in the host defense against viruses and bacteria, as well as in the immune surveillance against tumors. IFNs may be affected by and, in turn, affect signaling pathways to mediate anti-proliferative and antiviral responses in virus-induced tumorigenic context. New data on cellular and viral microRNAs (miRNAs) machinery, as well as cellular communication and microenvironment modification via classical secretion mechanisms and extracellular vesicles-mediated delivery are reported. Recent research is reviewed on the tumorigenesis induced by specific viruses with RNA or DNA genome, belonging to different families (i.e., HPV, HTLV-1, MCPyV, JCPyV, Herpesviruses, HBV, HCV) and the IFN system involvement.

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“…Thus, it is no wonder that viruses have evolved to exploit the use of miRNAs to alter host cell conditions that result in a favorable outcome for the virus. A master of exploiting miRNAs and noncoding RNAs to promote infection is Epstein-Barr virus (EBV) (reviewed in reference 6 ). EBV encodes 44 different miRNAs and two larger latently expressed EBV-encoded RNAs (EBERs), which are arguably the most studied of the viral encoded ncRNAs.…”

Section: Commentarymentioning

confidence: 99%

Reevaluating the Impact of Epstein-Barr Virus Noncoding RNAs on the Interferon Response

Murphy

2021

mBio

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A review on EBV encoded and EBV-induced host microRNAs expression profile in different lymphoma types

Cited by 14 publications

References 61 publications

Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

Virus-Induced Tumorigenesis and IFN System

Reevaluating the Impact of Epstein-Barr Virus Noncoding RNAs on the Interferon Response

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