A Review on Dengue Vaccine Development

Deng, Sheng-Qun; Xian, Yuezhong; Ye, Wei; Chen, Jiating; Wang, Xiaojun; Peng, Hong‐Juan

doi:10.3390/vaccines8010063

Cited by 117 publications

(93 citation statements)

References 101 publications

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“…The World Health Organization (WHO) established that CYD-TDV is immunogenic and safe in seropositive individuals due to clinical trial data. However, this vaccine's use on seronegative individuals could increase the risk of induction of severe dengue in those individuals due to an increased risk of antibodydependent enhancement [40,41]. To date, several approaches have been developed toward generating vaccines for the other arboviruses, including live-attenuated strains, inactivated strains, subunit, RNA DNA, and recombinant proteins.…”

Section: Arbovirusesmentioning

confidence: 99%

Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead

et al. 2021

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Arthropod-borne viruses (arboviruses) are a significant public health problem worldwide. Vaccination is considered one of the most effective ways to control arbovirus diseases in the human population. Nanoparticles have been widely explored as new vaccine platforms. Although nanoparticles’ potential to act as new vaccines against infectious diseases has been identified, nanotechnology’s impact on developing new vaccines to prevent arboviruses is unclear. Thus, we used a comprehensive bibliographic survey to integrate data concerning the use of diverse nanoparticles as vaccines against medically important arboviruses. Our analysis showed that considerable research had been conducted to develop and evaluate nanovaccines against Chikungunya virus, Dengue virus, Zika virus, Japanese encephalitis virus, and West Nile virus. The main findings indicate that nanoparticles have great potential for use as a new vaccine system against arboviruses. Most of the studies showed an increase in neutralizing antibody production after mouse immunization. Nevertheless, even with significant advances in this field, further efforts are necessary to address the nanoparticles’ potential to act as a vaccine against these arboviruses. To promote advances in the field, we proposed a roadmap to help researchers better characterize and evaluate nanovaccines against medically important arboviruses.

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Section: Arbovirusesmentioning

confidence: 99%

Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead

et al. 2021

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“…There are additional whole virus-based dengue vaccines in advance stages of clinical trials (Clinicaltrials.gov, 2020;Tricou et al, 2020). Moreover, a few recombinant dengue vaccine candidates are also at various stages of development (Vannice et al, 2015;Swaminathan and Khanna, 2019;Deng et al, 2020). It is great that the pipeline of dengue vaccines continue to increase.…”

Section: Introductionmentioning

confidence: 99%

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine

Shukla

Ramasamy

Shanmugam

et al. 2020

Front. Cell. Infect. Microbiol.

117

113

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“…the number of cases per 1000 population) dropped 14 cases from 2010 to 2018 (71–57 cases), however since 2014 the incidence remained stationary (57 cases), highlighting that the malaria challenge remains enormous and the development of new control measures is urgent. The difficulty in vaccine development [ 2 ], the increase of mosquito resistance to insecticides [ 3 ] as well as parasite resistance to anti-malarial drugs [ 4 ] all warrant the need for additional measures of control. Malaria prevention based on vector control, more specifically on genetic control, is an interesting intervention to be explored.…”

Section: Introductionmentioning

confidence: 99%

Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands

Kojin

Martín-Martín

Araújo

et al. 2021

Malar J

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Background The invasion of the mosquito salivary glands by Plasmodium sporozoites is a critical step that defines the success of malaria transmission and a detailed understanding of the molecules responsible for salivary gland invasion could be leveraged towards control of vector-borne pathogens. Antibodies directed against the mosquito salivary gland protein SGS1 have been shown to reduce Plasmodium gallinaceum sporozoite invasion of Aedes aegypti salivary glands, but the specific role of this protein in sporozoite invasion and in other stages of the Plasmodium life cycle remains unknown. Methods RNA interference and CRISPR/Cas9 were used to evaluate the role of A. aegypti SGS1 in the P. gallinaceum life cycle. Results Knockdown and knockout of SGS1 disrupted sporozoite invasion of the salivary gland. Interestingly, mosquitoes lacking SGS1 also displayed fewer oocysts. Proteomic analyses confirmed the abolishment of SGS1 in the salivary gland of SGS1 knockout mosquitoes and revealed that the C-terminus of the protein is absent in the salivary gland of control mosquitoes. In silico analyses indicated that SGS1 contains two potential internal cleavage sites and thus might generate three proteins. Conclusion SGS1 facilitates, but is not essential for, invasion of A. aegypti salivary glands by P. gallinaceum and has a dual role as a facilitator of parasite development in the mosquito midgut. SGS1 could, therefore, be part of a strategy to decrease malaria transmission by the mosquito vector, for example in a transgenic mosquito that blocks its interaction with the parasite.

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A Review on Dengue Vaccine Development

Cited by 117 publications

References 101 publications

Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead

Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine

Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands

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