A Review on Delivery and Bioavailability Enhancement Strategies of Azithromycin

Preparations and characterizations of effervescent granules containing azithromycin solid dispersion for children and elder: Solubility enhancement, taste-masking, and digestive acidic protection

“…A solid dispersion system is defined as a solid-phase system in which one or more drugs are dispersed in one or more pharmacologically inert carriers [ 14 , 15 ]. Solid dispersion has been proven to significantly improve the solubility of poor soluble drugs such as azithromycin [ 16 , 17 ]. Regarding the solid dispersion fabrication, two commonly utilized methods are the wet grinding method and the solvent evaporation method [ 18 ], which possess the advantages of less organic solvents and drug decomposition avoidance [ 14 , 19 ], and the homogenization of the drugs and the polymers [ 14 , 20 ], respectively.…”