A Review on Chemical Profile of Coumarins and their Therapeutic Role in the Treatment of Cancer

Sairam, K Venkata; Gurupadayya, Bannimath; Chandan, R S; Nagesha, Dattatri; Vishwanathan, B.

doi:10.2174/1567201812666150702102800

Cited by 82 publications

(28 citation statements)

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“…Based on the efficient drug screening, plenty of compounds with potential anticancer effects can be obtained. Lots of natural compounds, including terpenoids, quinones, alkaloids, saponins, coumarins, etc., have been proven to have potential anticancer effects [ 29 – 33 ]. Nevertheless, many natural products which possess superior effects in vitro may not show satisfying results in vivo, owing to their non-specific effect, adverse reactions in vivo, poor solubility or other drug-like properties.…”

Section: Development Of Natural Productsmentioning

confidence: 99%

Anticancer drug discovery from Chinese medicinal herbs

et al. 2018

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Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as targeted therapy and immunotherapy. Chinese medicinal herbs have attracted considerable attention due to their potential anticancer effects. Some natural products or formulae from Chinese medicinal herbs with directly or indirectly anticancer effects have been reported. In this article, we summarized the current progression on development of anticancer drugs from Chinese medicinal herbs, toward providing ideas for further development and application of Chinese medicinal herbs in cancer therapy.

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Section: Development Of Natural Productsmentioning

confidence: 99%

Anticancer drug discovery from Chinese medicinal herbs

et al. 2018

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“…On the other hand, coumarins are considered phytoalexins, because they are overaccumulated in plant tissues as a result of both pathogen attack and abiotic stresses. Their pharmacological properties are related to their substitution pattern (Venkata Sairam, Gurupadayya, Chandan, Nagesha, & Vishwanathan, 2016). The prototype of this class of molecules is coumarin, found in cinnamom and other plant, which can cause liver toxicity in several species, and it is considered a nongenotoxic carcinogen (Abraham, Wöhrlin, Lindtner, Heinemeyer, & Lampen, 2010).…”

Section: Phenolic Acids-hydroxycinnamic and Hydroxybenzoic Acidsmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

578

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…Condensed tannins are polymers of flavan-3-ols linked to one another by interflavan carbon bonds. [5][6][7]…”

Section: D)mentioning

confidence: 99%

Pharmacological Importance of Polyphenols: A Review

Sinha¹

2019

Int. Res. J. Pharm.

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Importance of plants in human society is immense. Since the advent of human civilization, the plants have been a major source of food for the human beings. In addition to it, humans also utilised plants for as important source of medicines which is now known as traditional medicine. At present, plants are getting importance not only as a source of food but also as a very important source of medicine and health supplements. Scientists at present are using the knowledge of traditional medicines as backbone to explore the chemical and molecular aspects of mechanism of action. Thus, the present focus of medical science is to exploit plants and their natural products for harvest of various medicinally important principles. Among various natural products found in plants, polyphenols are one of the most abundant. Based on the chemical structure they can be classified into phenolic acids, flavonoids, coumarins, lignans, stilbenes etc. They are widely distributed in almost all plants and exhibit strong antioxidant potential due to its unique molecular design. They have their origin from phenyl alanine or tyrosine and take the phenyl propanoid pathway for their synthesis. Apart from conferring protection to the plants from herbivore and other microbial attacks, polyphenols also possess a wide array of beneficial pharmacological activity. Presently they are largely used for treatment of cancer, diabetes, cardiovascular disease, arthritis, neurodegenerative disorders and many others. This review focuses on the sources and chemical nature of polyphenols and its beneficial pharmacological activities.

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A Review on Chemical Profile of Coumarins and their Therapeutic Role in the Treatment of Cancer

Cited by 82 publications

References 0 publications

Anticancer drug discovery from Chinese medicinal herbs

Anticancer drug discovery from Chinese medicinal herbs

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Pharmacological Importance of Polyphenols: A Review

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