A Review on Bioactive Peptides: Physiological Functions, Bioavailability and Safety

Bhandari, Divya Dhawal; Rafiq, Shafiya; Gat, Yogesh; Gat, Punam; Waghmare, Roji; Kumar, Vikas

doi:10.1007/s10989-019-09823-5

Cited by 191 publications

(120 citation statements)

References 94 publications

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“…A high number of plant and animal sources have been used for the isolation or production of peptides [ 117 ]. Peptides exhibit good biological functions and are well tolerated upon administration, as they are derived from natural sources.…”

Section: Micellar Drug Delivery Systems Based On Peptidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

145

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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Section: Micellar Drug Delivery Systems Based On Peptidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

145

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“…These peptides could reduce the level of lipids and lipoproteins in the blood by preventing the accumulation of high levels of cholesterol in blood vessels via lipase inhibition. Lipase inhibition in the gut has been reported to reduce postprandial triacylglycerols and fasting LDL, accelerate weight loss, prevent type II diabetes, and improve metabolism (Bhandari et al, 2020;Möller et al, 2008). According to Möller et al (2008), lipase inhibition could be achieved via direct interaction with the lipase or colipase, or through preventing the adsorption of enzyme via interaction with the oil-water-interface.…”

Section: Hypolipidemic and Hypocholesterolemic Activitiesmentioning

confidence: 99%

“…Peptides with specific sequences may form complexes by binding with minerals such as calcium, phosphorus, or any other elements in a solution at intestinal pH. Peptides with great anionic property could form soluble complexes with minerals and subsequently becoming resistant to further proteolytic activity of intestines and increasing the bioavailability of the minerals (Bhandari et al., 2020). A novel calcium‐binding peptide (FVDVT) was obtained from wheat germ protein hydrolyzate (Wang, Ding, et al., 2018).…”

Section: Structure–activity Relationship Of Bpsmentioning

confidence: 99%

Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development

Chai

Voo

Chen

2020

Comp Rev Food Sci Food Safe

140

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Bioactive peptides (BPs) are specific protein fragments that exert various beneficial effects on human bodies and ultimately influence health, depending on their structural properties and amino acid composition and sequences. By offering promising solutions to solve diverse health issues, the production, characterization, and applications of food-derived BPs have drawn great interest in the current literature and are of particular interest to the food and pharmaceutical industries. The microbial fermentation of protein from various sources is indubitably a novel way to produce BPs with numerous beneficial health effects. Apart from its lower cost as compared to enzymes, the BPs produced from microbial fermentation can be purified without further hydrolysis. Despite these features, current literature shows dearth of information on the BPs produced from food via microbial fermentation. Hence, there is a strong necessity to explore the BPs obtained from food fermentation for the development of commercial nutraceuticals and functional foods. As such, this review focuses on the production of BPs from different food sources, including the extensively studied milk and milk products, with emphasis on microbial fermentation. The structure-activity (antihypertensive, antioxidant, antimicrobial, opiate-like, anti-inflammatory, anticancer/antiproliferative, antithrombotic, hypolipidemic, hypocholesterolemic, and mineral binding) relationship, potential applications, future development, and challenges of BPs obtained from food fermentation are also discussed.

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“…Among these forefront candidates on trial, are the antimicrobial peptides (AMPs) (for recent reviews, see [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ]), which are ancient chemical weapons in the biological welfare. In unicellular organisms, AMPs help the producer cells to strive against competitors sharing the same ecological niche.…”

Section: Introductionmentioning

confidence: 99%

Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides

et al. 2020

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Cyanobacteria and microalgae are oxygen-producing photosynthetic unicellular organisms encompassing a great diversity of species, which are able to grow under all types of extreme environments and exposed to a wide variety of predators and microbial pathogens. The antibacterial compounds described for these organisms include alkaloids, fatty acids, indoles, macrolides, peptides, phenols, pigments and terpenes, among others. This review presents an overview of antibacterial peptides isolated from cyanobacteria and microalgae, as well as their synergism and mechanisms of action described so far. Antibacterial cyanopeptides belong to different orders, but mainly from Oscillatoriales and Nostocales. Cyanopeptides have different structures but are mainly cyclic peptides. This vast peptide repertoire includes ribosomal and abundant non-ribosomal peptides, evaluated by standard conventional methodologies against pathogenic Gram-negative and Gram-positive bacteria. The antibacterial activity described for microalgal peptides is considerably scarcer, and limited to protein hydrolysates from two Chlorella species, and few peptides from Tetraselmis suecica. Despite the promising applications of antibacterial peptides and the importance of searching for new natural sources of antibiotics, limitations still persist for their pharmaceutical applications.

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A Review on Bioactive Peptides: Physiological Functions, Bioavailability and Safety

Cited by 191 publications

References 94 publications

Micellar Drug Delivery Systems Based on Natural Biopolymers

Micellar Drug Delivery Systems Based on Natural Biopolymers

Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development

Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides

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