A review on bioactive glass, its modifications and applications in healthcare sectors

Dash, Pragyan Aparajita; Mohanty, Smita; Nayak, Sanjay K.

doi:10.1016/j.jnoncrysol.2023.122404

Cited by 17 publications

(2 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteogenic stimulation 1 and bone bonding abilities 2 are among the attractive biological properties of bioglasses that made them in the center of attention. During the last years, a number of glasses, ceramics, glass–ceramics and composites 3 – 5 have been employed in biomedical fields. These compounds were famous for their bioactivity and formation of chemical interactions with the surrounding bone via the generated mediate biological apatite layer.…”

Section: Introductionmentioning

confidence: 99%

Low temperature preparation of diopside nanoparticles: in-vitro bioactivity and drug loading evaluation

sobhani,

Salimi

2023

Sci Rep

View full text Add to dashboard Cite

Bioactive diopside (CaMgSi2O6) nanoparticles have recently gained potential usefulness as bone replacement materials and nano vehicles for delivering therapeutics. The structural characteristics of this ceramic have found to be a key factor in bone bonding ability. To attain the desired product for 100% clinical success, it is important to realize the relationship between structure and biological activity. Synthesis of these nanoparticles via the solid-state method has been regarded as a low-cost and easy process in large-scale, but time consuming reactions and high temperature (≈ 1400 °C) are required. On the other side, the wet chemistry can overcome these drawbacks, whereas the presence of byproducts in the final powder has limited this method in large-scale production. The present document has represented a simple, fast and one-pot sol–gel approach for the synthesis of highly pure diopside nano-powders (< 20 nm) by using not-expensive precursors. Calcination of the obtained powder has been conducted at various temperatures (700, 1000 and 1200 °C). The physicochemical and microstructural properties of the products have been characterized by XRD, FTIR, FESEM and TEM. Moreover, the impact of the crystallinity on the bioactivity, drug loading capacity and drug release behavior of the synthesized nanoparticles have been investigated here for the first time. The in-vitro bioactivity results of the prepared diopside samples in a simulated body fluid (SBF) at 37 °C revealed the higher capability of the sintered sample to deposit calcium phosphate, compared with the amorphous one. High quantity of gentamicin (around 10 µg) could attach to the surface of 1 miligram of the sintered diopside during the early stages of contact (3 h), suggesting the potential use of diopside as a new class of nano-vehicles for antibiotics. The release behavior indicated a sustained release of gentamicin (80%) after 24 h. In conclusion, diopside nanoparticles can be a promising candidate as a drug-vehicle for bone filling, implant coating or bone cement applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Low temperature preparation of diopside nanoparticles: in-vitro bioactivity and drug loading evaluation

sobhani,

Salimi

2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Bioglass is another bone graft substitute, and in contrast to calcium phosphate materials such as HA and β-TCP contains a combination of oxides, including silica (SiO 2 ), sodium oxide (CaO), and phosphorus pentoxide (P 2 O 5 ) [ 22 ]. This combination imparts bioactivity, triggers blood vessel formation, and releases ions (silica, calcium, sodium, and phosphate) that stimulate osteogenesis and angiogenesis [ 23 , 24 , 25 ]. Yuan et al demonstrated the osteoinductive properties of Bioglass by employing porous foam implants in the thigh muscles of dogs, following a 3-month in vivo experimental period [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Poly-ε-Caprolactone 3D-Printed Porous Scaffold in a Femoral Condyle Defect Model Induces Early Osteo-Regeneration

De Mori,

Karali,

Daskalakis

et al. 2023

Polymers

View full text Add to dashboard Cite

Large bone reconstruction following trauma poses significant challenges for reconstructive surgeons, leading to a healthcare burden for health systems, long-term pain for patients, and complex disorders such as infections that are difficult to resolve. The use of bone substitutes is suboptimal for substantial bone loss, as they induce localized atrophy and are generally weak, and unable to support load. A combination of strong polycaprolactone (PCL)-based scaffolds, with an average channel size of 330 µm, enriched with 20% w/w of hydroxyapatite (HA), β-tricalcium phosphate (TCP), or Bioglass 45S5 (Bioglass), has been developed and tested for bone regeneration in a critical-size ovine femoral condyle defect model. After 6 weeks, tissue ingrowth was analyzed using X-ray computed tomography (XCT), Backscattered Electron Microscopy (BSE), and histomorphometry. At this point, all materials promoted new bone formation. Histological analysis showed no statistical difference among the different biomaterials (p > 0.05), but PCL-Bioglass scaffolds enhanced bone formation in the center of the scaffold more than the other types of materials. These materials show potential to promote bone regeneration in critical-sized defects on load-bearing sites.

show abstract

A comparative in vitro and in vivo analysis of the impact of copper substitution on the cytocompatibility, osteogenic, and angiogenic properties of a borosilicate bioactive glass

Fiehn,

Kunisch,

Saur

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

The 0106‐B1‐bioactive glass (BG) composition (in wt %: 37.5 SiO2, 22.6 CaO, 5.9 Na2O, 4.0 P2O5, 12.0 K2O, 5.5 MgO, and 12.5 B2O3) has demonstrated favorable processing properties and promising bone regeneration potential. The present study aimed to evaluate the biological effects of the incorporation of highly pro‐angiogenic copper (Cu) in 0106‐B1‐BG in vitro using human bone marrow‐derived mesenchymal stromal cells (BMSCs) as well as its in vivo potential for bone regeneration. CuO was added to 0106‐B1‐BG in exchange for CaO, resulting in Cu‐doped BG compositions containing 1.0, 2.5 and 5.0 wt % CuO (composition in wt %: 37.5 SiO2, 21.6/ 20.1/17.6 CaO, 5.9 Na2O, 4.0 P2O5, 12.0 K2O, 5.5 MgO, 12.5 B2O3, and 1.0/ 2.5/ 5.0 CuO). In vitro, the BGs' impact on the viability, proliferation, and growth patterns of BMSCs was evaluated. Analyses of protein secretion, matrix formation, and gene expression were used for the assessment of the BGs' influence on BMSCs regarding osteogenic differentiation and angiogenic stimulation. The presence of Cu improved cytocompatibility, osteogenic differentiation, and angiogenic response when compared with unmodified 0106‐B1‐BG in vitro. In vivo, a critical‐size femoral defect in rats was filled with scaffolds made from BGs. Bone regeneration was evaluated by micro‐computed tomography. Histological analysis was performed to assess bone maturation and angiogenesis. In vivo effects regarding defect closure, presence of osteoclastic cells or vascular structures in the defect were not significantly changed by the addition of Cu compared with undoped 0106‐B1‐BG scaffolds. Hence, while the in vitro properties of the 0106‐B1‐BG were significantly improved by the incorporation of Cu, further evaluation of the BG composition is necessary to transfer these effects to an in vivo setting.

show abstract

A review on bioactive glass, its modifications and applications in healthcare sectors

Cited by 17 publications

References 152 publications

Low temperature preparation of diopside nanoparticles: in-vitro bioactivity and drug loading evaluation

Low temperature preparation of diopside nanoparticles: in-vitro bioactivity and drug loading evaluation

Poly-ε-Caprolactone 3D-Printed Porous Scaffold in a Femoral Condyle Defect Model Induces Early Osteo-Regeneration

A comparative in vitro and in vivo analysis of the impact of copper substitution on the cytocompatibility, osteogenic, and angiogenic properties of a borosilicate bioactive glass

Contact Info

Product

Resources

About