A Review on Anticancer Potential of Natural Drugs:  Hispolon and Limonene

Sekhar, K. Chandra; Rajanikanth, A.; Bobby, Md. Nazneen; Kanala, Jagadeeswara Reddy

doi:10.20546/ijcmas.2018.711.375

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…The anticancer properties of the major components in S. verbenaca (carvacrol, limonene, and thymol) have also been reported recently [ 80 – 82 ]. Thymol has been shown to have anticancer properties via a variety of mechanisms, including inducing severe DNA damage, including the production of reactive oxygen species (ROS) and subsequent increase in oxidative stress and/or mitochondrial dysfunction, or via the nuclear factor of activated T cell (NFAT-2) route [ 81 ].…”

Section: Methodsmentioning

confidence: 93%

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Mrabti

Menyiy²,

Charfi

et al. 2022

BioMed Research International

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The family Lamiaceae contains several plants used in traditional medicine to fight against different diseases. Salvia verbenaca L. (S. verbenaca) is one of the Lamiaceae species distributed around the Mediterranean regions. This plant exhibits different bioactive properties, including antibacterial, anticancer, antioxidant, antileishmanial, antidiabetic, immunomodulatory, and wound healing. This review was conducted to revise previous studies on S. verbenaca addressing its botanical description, geographical distribution, and phytochemical, pharmacological, and toxicological properties. Moreover, the main pharmacological actions of S. verbenaca major compounds were well investigated. Literature reports have revealed that S. verbenaca possesses a pivotal role in medicinal applications. The findings of this work noted that S. verbenaca was found to be rich in chemical compound classes such as terpenoids, phenolics, fatty acids, sterols, and flavonoids. Numerous studies have found that S. verbenaca essential oils and extracts have a wide range of biological effects. These results support the potential pharmacological properties of S. verbenaca and its traditional uses. This analysis can constitute a scientific basis for further refined studies on its pure secondary metabolites. Therefore, the outcome of the present work may support the perspective of identifying new therapeutical applications with detailed pharmacological mechanisms of S. verbenaca to prevent the development of some diseases such as neurodegenerative disorders. However, toxicological investigations into S. verbenaca are needed to assess any potential toxicity before it can be further used in clinical studies.

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Section: Methodsmentioning

confidence: 93%

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Mrabti

Menyiy²,

Charfi

et al. 2022

BioMed Research International

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“…Numerous studies have been published on the anticancer activity of the main compounds of oregano EOs such as limonene, carvacrol, and thymol [62][63][64]. Islam et al [63] determined that the mechanism of action of thymol in a cancer cell caused severe DNA damage through several mechanisms (e.g., ROS induction and subsequent increase in oxidative stress and/or mitochondrial dysfunction or nuclear factor of activated T-cells (NFAT-2) pathway), which eventually upregulates Bax/Bcl-2 protein expression and results in the cytochrome-(cyto-) c release from the mitochondria (intrinsic pathway).…”

Section: Biological Mechanism Insights Into O Elongatum Main Compoundsmentioning

confidence: 99%

Phytochemistry, Toxicology, and Pharmacological Properties of Origanum elongatum

Balahbib

Menyiy

Omari

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Origanum elongatum L. is an endemic aromatic and medicinal plant. This work reports previous studies on O. elongatum concerning its taxonomy, botanical description, geographical distribution, bioactive compounds, toxicology, and biological effects. Chemical analyses showed that O. elongatum contains different chemical compounds, in particular volatile compounds. Pharmacological investigations showed that volatile compounds and extracts from O. elongatum exhibit different pharmacological properties, such as antibacterial, antifungal, antiviral, antioxidant, vasodilator, corrosion inhibitor, and hepatoprotective effects. Moreover, toxicological reports revealed the safety of this species. The pharmacological effects of O. elongatum could be correlated with the main compounds, which exhibit different pharmacological properties with numerous mechanism insights.

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“…Hispolon belongs to a polyphenol compound, which was found in several types of mushrooms such as Inonotus hispidus , Phallus linteus , and Phellinus igniarius 18 . To date, hispolon has been widely discovered to have the activities of anti‐virus, 18 anti‐oxidant, 19 anti‐inflammatory, 20 hepato‐protective, 21 and anticancer 22 . Huang et al have shown the apoptotic effect of hispolon by modulating ERK pathway on hepatocellular carcinoma cells 23 .…”

Section: Introductionmentioning

confidence: 99%

Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK/HO‐1 pathway activation

Yang

Chen

et al. 2023

J Cellular Molecular Medi

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Oral squamous cell carcinoma (OSCC) has a high recurrence rate and poor prognosis. Hispolon, a polyphenolic compound with antiviral, antioxidant, and anticancer activities, is a potential chemotherapy agent. However, few studies have investigated the anti‐cancer mechanism of hispolon in oral cancer. This present study used the cell viability assay, clonogenic assay, fluorescent nuclear staining, and flow cytometry assay to analyse the apoptosis‐inducing effects of hispolon in OSCC cells. After hispolon treatment, the apoptotic initiators, cleaved caspase‐3, −8, and − 9, were upregulated, whereas the cellular inhibitor of apoptosis protein‐1 (cIAP1) was downregulated. Furthermore, a proteome profile analysis using a human apoptosis array revealed the overexpression of heme oxygenase‐1 (HO‐1) by hispolon, which was determined to be involved in caspase‐dependent apoptosis. Moreover, cotreatment with hispolon and mitogen‐activated protein kinase (MAPK) inhibitors revealed that hispolon induces apoptosis in OSCC cells through activation of the c‐Jun N‐terminal kinase (JNK) pathway and not the extracellular signal‐regulated kinase (ERK) or p38 pathway. These findings indicate that hispolon may exert an anticancer effect on oral cancer cells by upregulating HO‐1 and inducing caspase‐dependent apoptosis by activating the JNK pathway.

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A Review on Anticancer Potential of Natural Drugs: Hispolon and Limonene

Cited by 6 publications

References 29 publications

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Phytochemistry, Toxicology, and Pharmacological Properties of Origanum elongatum

Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK/HO‐1 pathway activation

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