A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach

Agarwal, Happy; Shanmugam, VenkatKumar

doi:10.1016/j.bioorg.2019.103423

Cited by 109 publications

(62 citation statements)

References 80 publications

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“…ZnO NP have many beneficial properties, such as catalytic, anti-bacterial, and anti-inflammatory activities. They promote wound healing and can be used for bio-imaging [ 36 ]. The U.S. Food and Drug Administration has listed zinc as generally recognised as safe, because it is an essential micronutrient.…”

Section: Discussionmentioning

confidence: 99%

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Mittag

Hoera

Kämpfe

et al. 2021

Toxics

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Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Consequently, the aim of our study was to investigate the cellular uptake of two differently sized ZnO NP (<50 nm and <100 nm; 12–1229 µmol/L) using two human intestinal cell lines (Caco-2 and LT97) and to examine the possible resulting toxic effects. ZnO NP (<50 nm and <100 nm) were internalized by both cell lines and led to intracellular changes. Both ZnO NP caused time- and dose-dependent cytotoxic effects, especially at concentrations of 614 µmol/L and 1229 µmol/L, which was associated with an increased rate of apoptotic and dead cells. ZnO NP < 100 nm altered the cell cycle of LT97 cells but not that of Caco-2 cells. ZnO NP < 50 nm led to the formation of micronuclei in LT97 cells. The Ames test revealed no mutagenicity for both ZnO NP. Our results indicate the potential toxicity of ZnO NP after oral exposure, which should be considered before application.

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Section: Discussionmentioning

confidence: 99%

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Mittag

Hoera

Kämpfe

et al. 2021

Toxics

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show abstract

“…In engineering, ZnO nanoparticles are used in solar cells [45,46], gas sensors, in particular, sensors for Liquefied petroleum gas (LPG) and EtOH [47], chemical sensors and biosensors, in LEDs, photodetectors [48,49]. In biology and medicine, the cytostatic activity of ZnO nanoparticles (ZnO-NPs) against cancer cells [50], antimicrobial and fungicidal activities [51,52], anti-inflammatory activity [53,54], ability to accelerate wound healing [55], a possibility to use in bioimaging due to chemiluminescent properties of nanoparticles [56,57], antidiabetic properties [58,59] are of great interest.…”

Section: Introductionmentioning

confidence: 99%

A Mini Review of Antibacterial Properties of ZnO Nanoparticles

et al. 2021

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The development of antibiotic resistance of bacteria is one of the most pressing problems in world health care. One of the promising ways to overcome microbial resistance to antibiotics is the use of metal nanoparticles and their oxides. In particular, numerous studies have shown the high antibacterial potential of zinc oxide nanoparticles (ZnO-NP) in relation to gram-positive and gram-negative bacteria. This mini-review includes an analysis of the results of studies in recent years aimed at studying the antibacterial activity of nanoparticles based on zinc oxide. The dependence of the antibacterial effect on the size of the applied nanoparticles in relation to E. coli and S. aureus is given. The influence of various ways of synthesis of zinc oxide nanoparticles and the main types of modifications of NP-ZnO to increase the antibacterial efficiency are also considered.

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“…This green synthesis approach replaces the use of toxic chemicals, as reducing and stabilizing agents, with phytochemicals during NPs synthesis. 104 Phytochemicals coating onto NPs surface guarantee their biocompatibility and bacteriostatic properties. Thanks to their antioxidant and anti-inflammatory properties, green synthetized nanoparticles may play an important role in many therapeutic applications.…”

Section: Nutraceutical Loaded Nps and Green Npsmentioning

confidence: 99%

“…Thanks to their antioxidant and anti-inflammatory properties, green synthetized nanoparticles may play an important role in many therapeutic applications. Very recent studies demonstrated that green zinc oxide NPs maintained their high antioxidant properties, 104 procyanidins fractions from Leucosidea sericea were employed in the synthesis of stable and active AuNPs, 105 quercetin was used in the synthesis of gold and silver NPs, 106 and, finally, silver NPs synthesized by macerating in the powdered fresh aerial parts of two plants, Lampranthus coccineus and Malephora lutea, demonstrated, in vitro, an anti-AchE and an antioxidant activities comparable to rivastigmine, suggesting their potential application in AD. 107 Nucleic Acid Applications in AD Preliminary results suggest that gene therapy combined with NPs to improve brain delivery might have a great potential in AD treatment.…”

Section: Nutraceutical Loaded Nps and Green Npsmentioning

confidence: 99%

<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>

Binda¹,

Murano²,

Rivolta³

2020

IJN

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The field of nanomedicine is constantly expanding. Since the first work dated in 1999, almost 28 thousand articles have been published, and more and more are published every year: just think that only in the last five years 20,855 have come out (source PUBMED) including original research and reviews. The goal of this review is to present the current knowledge about nanomedicine in Alzheimer's disease, a widespread neurodegenerative disorder in the over 60 population that deeply affects memory and cognition. Thus, after a brief introduction on the pathology and on the state-of-the-art research for NPs passing the BBB, special attention is placed to new targets that can enter the interest of nanoparticle designers and to new promising therapies. The authors performed a literature review limited to the last three years (2017-2020) of available studies with the intention to present only novel formulations or approaches where at least in vitro studies have been performed. This choice was made because, while limiting the sector to nanotechnology applied to Alzheimer, an organic census of all the relevant news is difficult to obtain.

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A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach

Cited by 109 publications

References 80 publications

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

A Mini Review of Antibacterial Properties of ZnO Nanoparticles

<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>

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