A review on anti-cancer effect of green tea catechins

Cheng, Zhe; Zhang, Zhifa; Han, Yu; Wang, Jing; Wang, Yongyong; Chen, Xiaoqiang; Shao, Yundong; Cheng, Yue; Zhou, Weilong; Lu, Xiaolei; Wu, Zhengqi

doi:10.1016/j.jff.2020.104172

Cited by 114 publications

(74 citation statements)

References 197 publications

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“…Tanto os efeitos quimiopreventivos quanto os terapêuticos do chá verde no combate ao câncer oral devem ser explorados, visto que é um produto natural de baixo custo, com quase nenhum efeito adverso. Os efeitos terapêuticos das catequinas do chá verde no câncer incluem a inibição do estresse oxidativo, indução da apoptose, inibição da angiogênese e inibição de metástases em vários estágios da tumorigênese por meio da modulação de vias de sinalização, de atividade enzimática e de proteínas quinases (Cheng et al, 2020). Já a quimioprevenção é o uso de produtos naturais ou químicos sintéticos para a reversão, supressão ou prevenção da transformação de células pré-malignas para a forma maligna .…”

Section: Discussionunclassified

Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

Filho

Singh

et al. 2021

RSD

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Objetivo: Avaliar o efeito antitumoral do chá verde e seus compostos naturais no carcinoma de células escamosas oral (CCEO). Metodologia: Trata se de uma revisão integrativa da literatura a partir da questão norteadora “O chá verde tem efeito antitumoral no desenvolvimento do CCEO?”. A busca foi realizada com os descritores “Camellia sinensis”, “Green tea”; “Oral cancer”; “squamous cell carcinoma”; “animals” e “anticarcinogenic agents” nas bases de dados PubMed, Science Direct, Scielo e Google Acadêmico. Os critérios de inclusão foram artigos científicos sobre o efeito do chá verde, na forma de extrato ou compostos isolados, no CCEO, estudos in vivo, em qualquer idioma. Resultados: Obteve-se um total de 1.245 artigos, dentre os quais 11 foram selecionados. A maioria dos estudos (90,9%) foi realizada por países orientais. A epigalocatequina-galato, hamsters e DMBA foram os compostos, modelo animal e carcinógeno mais usados, respectivamente. Observou-se diversos mecanismos de ação (estresse oxidativo, apoptose, inibição da proliferação e diferenciação celular) e efeitos moleculares (alteração na expressão de glicoconjugados, proteínas precursoras amilóides, metaloproteinases e na formação de invadopódios) do chá verde no CCEO. Considerações finais: O chá verde possui efeito antitumoral no carcinoma de células escamosas oral, exercendo ação tanto quimiopreventiva quanto terapêutica, por diferentes vias. Por ser um produto natural, biocompatível, seguro e de fácil acesso/baixo custo seu uso deve ser explorado de forma a contribuir para o tratamento/prevenção do CCEO, o tipo mais frequente de câncer oral.

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Section: Discussionunclassified

Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

Filho

Singh

et al. 2021

RSD

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“…Their results showed that A. niger and A. tubingensis produced eriodictyol, while A. japonicus and A. aculeatus produced taxifolin and catechin. These phenolic compounds have several health benefits: eriodictyol is a flavonoid with broad biological and pharmacological effects [231], including anti-inflammatory effect in osteoarthritis [232], cardioprotective effect [233], control of blood vessels permeability [234] and anti-allergic effect [235]; taxifolin is also a flavonoid with biological activities at different levels, showing antioxidant [236], antibacterial, anti-inflammatory [237] and antiviral [238] activities, improving microcirculation and regulating immunity, being used for treatment of atherosclerosis, dyslipidemia, cardiovascular diseases and other chronic diseases [239,240]; catechin, again in the class of flavonoids, has proven beneficial in cardiovascular health and showing several effects on the human body [241], like antioxidant [242], antihypertensive [243], anti-inflammatory [244], antiproliferative [245] and anti-hyperlipidemic [246].…”

Section: Health Effects Of Fermented Apple Productsmentioning

confidence: 99%

Apple Fermented Products: An Overview of Technology, Properties and Health Effects

et al. 2021

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As an easily adapted culture, with overloaded production in some parts of the globe, apples and their by-products are being redirected to pharmaceutical, canning and beverages industries, both alcoholic and non-alcoholic. Fermentation is generally considered to increase the bioavailability of bioactive compounds found in apple, by impacting, through a high degree of changes, the product’s properties, including composition and health-promoting attributes, as well as their sensory profile. Probiotic apple beverages and apple vinegar are generally considered as safe and healthy products by the consumers. Recently, contributions to human health, both in vivo and in vitro studies, of non-alcoholic fermented apple-based products have been described. This review highlighted the advances in the process optimization of apple-based products considering vinegar, cider, pomace, probiotic beverages and spirits’ technologies. The different processing impacts on physical-chemical, nutritional and sensory profiles of these products are also presented. Additionally, the harmful effects of toxic compounds and strategies to limit their content in cider and apple spirits are illustrated. New trends of fermented apple-based products applicability in tangential industries are summarized.

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“…Breast, lung, prostate, skin, colon, stomach, and liver are the sites where cancers most frequently occur [ 18 ]. Green tea catechins have shown therapeutic effects against multiple types of cancers in vitro and in vivo [ 5 , 19 ]. Herein, we review the major cancer-inhibition mechanisms of catechins ( Figure 2 ).…”

Section: Anticancer Activity Of Green Tea Catechinsmentioning

confidence: 99%

“…Overexpression of COX, especially COX-2, can catalyze the conversion of arachidonic acid to prostaglandins, which promotes inflammation. COX-2 is downregulated in multiple types of cancers by catechins [ 19 ]. The lipoxygenases (LOX), particularly 5-LOX and 12-LOX play important roles in inflammatory diseases [ 45 ].…”

Section: Anticancer Activity Of Green Tea Catechinsmentioning

confidence: 99%

Advances in Nanodelivery of Green Tea Catechins to Enhance the Anticancer Activity

Jiang

2021

Molecules

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Cancer is one of the leading causes of death globally. A variety of phenolic compounds display preventative and therapeutic effects against cancers. Green teas are rich in phenolics. Catechins are the most dominant phenolic component in green teas. Studies have shown that catechins have anticancer activity in various cancer models. The anticancer activity of catechins, however, may be compromised due to their low oral bioavailability. Nanodelivery emerges as a promising way to improve the oral bioavailability and anticancer activity of catechins. Research in this area has been actively conducted in recent decades. This review provides the molecular mechanisms of the anticancer effects of catechins, the factors that limit the oral bioavailability of catechins, and the latest advances of delivering catechins using nanodelivery systems through different routes to enhance their anticancer activity.

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A review on anti-cancer effect of green tea catechins

Cited by 114 publications

References 197 publications

Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

Apple Fermented Products: An Overview of Technology, Properties and Health Effects

Advances in Nanodelivery of Green Tea Catechins to Enhance the Anticancer Activity

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