A Review on Anomalin: A Natural Bioactive Pyranocoumarin from the Past to the Future

Abstract

Anomalin is a seselin-type pyranocoumarin isolated for the first time from Angelica anomala Avé-Lal, but is also found in several other plant species, especially in Apiaceae. This lipophilic molecule possesses pharmacologically beneficial activities for human health. The major scientific databases Scopus, Web of Science, Google Scholar, and PubMed up to the end of 2021 and the combining terms anomalin, praeruptorin, isolation, structure elucidation, and biological activity were used in the research of this review. This review focuses on the sources, structural properties, and biological functions of anomalin and provides future trends in the investigation of anomalin, particularly in therapies for many common diseases such as anti-inflammatory and neurodegenerative illnesses. As a potential bioactive molecule, prospective studies on anomalin should be done through supported clinical trials. At the end, this review confirms the significant pharmacological potential of anomalin.

Integrative analysis of chloroplast genome, chemicals, and illustrations in Bencao literature provides insights into the medicinal value of Peucedanum huangshanense

“…Praeruptorin B can inhibit osteoclast formation, thus treating osteoporosis and exerting anti-cancer effects (Lin et al, 2020;Xu et al, 2022). Pyranocoumarin can relieve neuropathic pain and neuroinflammatory reactions and exert anti-inflammatory effects (Onder and Trendafilova, 2022). Based on the main coumarin components of P. huangshanense, it can be speculated that P. huangshanense may has effects of anti-cancer, anti-inflammatory, anti-diabetic, bacteriostatic, and osteoporosis.…”

Synthesis and Biological Properties of Pyranocoumarin Derivatives as Potent Anti-Inflammatory Agents

“…Decursin and its derivatives from the herb Angelica gigas possess potent antiandrogen receptor activities and induce cell cycle arrest and caspase-mediated apoptosis [ 10 ]. Anomalin, isolated from Angelica anomala Ave-Lal for the first time, has been shown to have many biological activities, including anti-inflammatory, analgesic, antioxidant, antitumor, hepatoprotective, and neuroprotective activities [ 11 ]. Arisugacin A and B, isolated from a culture broth of Penicillium sp.…”