A review on advances in graphene-derivative/polysaccharide bionanocomposites: Therapeutics, pharmacogenomics and toxicity

Makvandi, Pooyan; Ghomi, Matineh; Ashrafizadeh, Milad; Tafazoli, Alireza; Agarwal, Tarun; Delfi, Masoud; Akhtari, Javad; Zare, Ehsan Nazarzade; Padil, Vinod V.T.; Zarrabi, Ali; Pourreza, Nahid; Miltyk, Wojciech; Maiti, Tapas K.

doi:10.1016/j.carbpol.2020.116952

Cited by 56 publications

(19 citation statements)

References 189 publications

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“…encapsulations or functionalization strategies. [97][98][99] Ionic liquids are biocompatible and possess effective antibacterial properties. They have found applications in the domains of tissue engineering and regenerative medicine.…”

Section: Regenerative Medicinementioning

confidence: 99%

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Nikfarjam

Ghomi

Agarwal

et al. 2021

Adv Funct Materials

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120

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Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibioticresistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.

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Section: Regenerative Medicinementioning

confidence: 99%

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Nikfarjam

Ghomi

Agarwal

et al. 2021

Adv Funct Materials

Self Cite

150

120

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“…Modification of GBMs with functional groups or macromolecules, as discussed in the previous sections, are promising strategies to improve aqueous dispersibility, biocompatibility and stability, and biodegradability of the GBMs as well as facilitating high drug loading capacity, target ability, and more, which consequently enhance their biotherapeutic efficacy. [ 91 ] However, pharmacogenomic and toxicity assessments of these bionanocomposites are needed to broaden our understanding of their potential toxicity and to direct further studies into overcoming negative biological effects through safe‐ by‐design approaches in order to enable their safe use in biomedical applications. GBMs, like many nanomaterials, can access the human body in different ways, for example, inhalation, intentionally via intravenous or intranasal administration for drug delivery, or as implants for tissue engineering.…”

Section: Toxicity Of Functionalized Gbmsmentioning

confidence: 99%

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

et al. 2021

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drug delivery, bioimaging probes, antibacterial agents, and tissue engineering. [2] The advantage of GBMs over other nanomaterials (NMs) in biomedical application is their high specific surface area which allows high density functionalization and drug loading on both sides of the planar structure. [3] The π-conjugated system offers high capacity for GBMs to interact with various organic compounds with aromatic structures through π-π stacking during fabrication of graphene composites or for immobilization of biomolecules such as nucleic acids, peptides, antibodies, or other therapeutic substances. [4] The same properties may also raise concerns regarding the potential risk that GBMs may cause to human health through binding of key signaling molecules for example. GBMs may interact with biomolecules, changing the structure of protein or DNA or induce oxidative damage, and so on. [5] Therefore, prior to the widespread use of GBMs, it is imperative to evaluate their potential risk to environmental and human health and to establish a proactive approach for the safe design of these materials.In a recent review article, Fadeel et al. comprehensively examined the literature on the effects of GBMs on human health and the environment and gave an overview of the state-of-the-art of safety assessment of GBMs, highlighting the importance of The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

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“…Carriers such as biopolymer nanoparticles can be used as matrices, hydrogels, or coating agents. This type of carrier must protect the drug, peptides, and proteins from the challenging conditions of the stomach and intestine, increase intestinal absorption in the bloodstream, allow specific cells in the human body to be reached, and ensure controlled release [101,102].…”

Section: Factors That Influence Colon-targeted Drug Deliverymentioning

confidence: 99%

Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

et al. 2021

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Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

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A review on advances in graphene-derivative/polysaccharide bionanocomposites: Therapeutics, pharmacogenomics and toxicity

Cited by 56 publications

References 189 publications

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

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