A review of α-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes

Najafian, Mahmood

doi:10.1007/s00580-014-1967-x

Cited by 75 publications

(51 citation statements)

References 88 publications

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“…Therefore curcumin is a nearly highly potent inhibitor for alpha amylase. Plants derived polyphenols such as quercetagetin, fisetin and quercetin which belong to the flavonoid family, have been shown to be effective inhibitors of mammalian alphaamylase with IC50s in the order of µM which is consistent with current research [20]. In Najafian et al study trans chalcon inhibited alpha amylase.…”

Section: Discussionsupporting

confidence: 63%

“…In animals, administration of STZ caused high levels of blood glucose [10,17,18,20]. In diabetic and normal groups with administration curcumin, decreased blood glucose levels.…”

Section: Discussionmentioning

confidence: 99%

“…Grape seed ethanolic extract has been suggested to be beneficial in a rat model of type 2 diabetes. The main component of grape seed "oil" seems to be linoleic acid [20]. Different doses of curcumin and grape seed oil (as solvent of curcumin) were administrated orally for 30 days through a gastric cannula in a single dose (0.5 mL) at 8:30 am.…”

Section: Treatment With Curcuminmentioning

confidence: 99%

“…Flavonoid-rich fractions of plants have also been reported to be effective as antihyperglycemic and antihyperlipidemic agents in animal models of diabetes [19]. Plants derived polyphenols such as quercetagetin, fisetin and quercetin, which belong to the flavonoid family have been shown to be effective inhibitors of mammalian alphaamylase with IC50s in the order of micromolar [20].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Curcumin on Alpha Amylase in Diabetics Rats

Najafian

2015

Zahedan J Res Med Sci

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Section: Discussionsupporting

confidence: 63%

“…In animals, administration of STZ caused high levels of blood glucose [10,17,18,20]. In diabetic and normal groups with administration curcumin, decreased blood glucose levels.…”

Section: Discussionmentioning

confidence: 99%

Section: Treatment With Curcuminmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Curcumin on Alpha Amylase in Diabetics Rats

Najafian

2015

Zahedan J Res Med Sci

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“…Excessive weight and obesity can lead to type 2 diabetes (T2D) which is rapidly becoming a major health problem worldwide (Mahmood, ). In most diets, carbohydrates are the main source of calories.…”

Section: Introductionmentioning

confidence: 99%

In vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activity

Spínola

Pinto

Castilho

2016

Journal of Food Biochemistry

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Inhibition of enzymes involved in carbohydrate and lipids metabolism is an important strategy against type 2 diabetes and obesity, by suppressing dietary sugar and fat absorption. This work reports, for the first time, the in vitro inhibition of α‐glucosidase, α‐amylase and lipase by watercress juice (WJ). Juice was analyzed for qualitative and quantitative composition and in vitro antioxidant activities. Several components were identified, namely hydroxycinnamic acids, flavonols, and other minor water‐soluble phytochemicals. Quantitative data revealed a dimer of caffeoylmalic acid (0.73 mg mL−1 of juice), disinapoylgentibiose (0.64 mg mL−1), ferulic acid (0.56 mg mL−1), and isorhamnetin‐O‐sophoroside‐O‐malonyl(hexoside) (0.38 mg mL−1) as the predominant polyphenols. The results showed that WJ had dose‐dependent inhibitory potential against targeted enzymes, displaying a more potent inhibitory effect against α‐glucosidase relative to α‐amylase and lipase. WJ can be considered a potential complementary dietary approach to control hyperglycaemia and hyperlipidaemia, through inhibition of digestive enzymes. Practical applications Currently, raw watercress is widely consumed in liquid form, alone or together with other fresh vegetables, as an ingredient of the “detox juices.” Studies on watercress phenolic composition and antidiabetic properties have been performed on extracts, but not on juice, which is closer to the edible form. The present study supports consumption of watercress juice as source of phytochemicals potentially capable of inhibiting digestive enzymes linked to diabetes and obesity prevention/control.

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Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

Loizzo

Bruno²,

Balzano

et al. 2018

Euro J Lipid Sci & Tech

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This study investigates the seed oils obtained from two different varieties of Opuntia ficus‐indica (Sanguigna and Surfarina) growing in Sicily, Italy. Soxhlet and ultrasound‐assisted extraction procedures are used to obtain the seed oils. The fatty acid profile, γ‐tocopherols, carotenoid content, and the bioactivity in terms of the antioxidant effects (using ABTS, DPPH, FRAP, and β‐carotene bleaching tests), and carbohydrate‐hydrolysing enzyme inhibitory activity (α‐amylase and α‐glucosidase) are determined. The extraction procedure does not significantly affect the fatty acid composition of the oil, but it does affect the tocopherol and carotenoid contents, as well as the antioxidant and inhibitory activities. All the oil samples are rich in polyunsaturated fatty acids, especially linoleic, and oleic acids. Soxhlet extraction proves to be the best extraction procedure to enrich the oils in γ‐tocopherol. Relative antioxidant capacity index (RACI) and global antioxidant score (GAS) analyses are applied to evaluate the antioxidant potential of the Sanguigna variety oil extracted with the Soxhlet apparatus that is shown to be the most active. The same oil also shows the highest α‐amylase inhibitory activity (IC50 value of 40.9 μg mL−1), which is better than that reported for acarbose used as a positive control. Practical Applications: This study is the first to evaluate the effect of oil extraction technologies on the bioactive compound levels and antioxidant and hypoglycaemic activities of cactus pear seed oil, which is a by‐product of fruit processing. The findings will contribute to the valorization of food by‐products. The results provide useful information to select the most valuable technological conditions for oil extraction to preserve the bioactive compounds and the biological activity of the vegetable by‐product extracts, such as seed oil. Cactus pear seed oil obtained by the traditional extraction procedure (Soxhlet) represents a promising source of healthy compounds, particularly of carotenoids and γ‐tocopherol, used not only as antioxidants to preserve lipid components in food preparation but also as functional ingredients due to their hypoglycaemic effect. Effect of extraction procedure on chemical composition, antioxidant potential, and hypoglycaemic activity of cactus pear seed oils.

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A review of α-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes

Cited by 75 publications

References 88 publications

The Effects of Curcumin on Alpha Amylase in Diabetics Rats

The Effects of Curcumin on Alpha Amylase in Diabetics Rats

In vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activity

Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

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