A review of unusual systemic manifestations associated with carcinoma

Greenberg, E. P.; Divertie, Matthew B.; Woolner, Lewis B.

doi:10.1016/0002-9343(64)90153-6

Cited by 92 publications

(23 citation statements)

References 113 publications

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“…'~ Although such thrombosis may occur in patients with any primary carcinoma, mucus-secreting carcinomas are most commonly as~ociated.26.~e Many mechanisms have been proposed to account for this hypercoagulable state, but none has been substantiated. 13, Consideration of this clinicopathologk entity in the differential diagnosis of respiratory distress is more than academic. In the present series, microscopic tumor emboli were found in 2.4% of cases of solid malignant neoplasms.…”

Section: Vol 36mentioning

confidence: 99%

Pulmonary Tumor Emboli

Kane

Hawkins

Miller

et al. 1975

Cancer

189

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A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins of tumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electro‐cardiographic examinations were not diagnostic. Clinical or morphological evidence of cor pulmonale was present in only 5 of these 8 cases. The tumor emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.

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Section: Vol 36mentioning

confidence: 99%

Pulmonary Tumor Emboli

Kane

Hawkins

Miller

et al. 1975

Cancer

189

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“…The biochemical abnormalities include an elevated serum alkaline phosphatase level, increased BSP retention, decreased serum albumin, and an elevation of total globulins and/or alpha 2 globulin. Anemia, thrombocytosis, and an elevation of haptoglobulins may also be present (2,4,5,8,11). Microscopically, liver biopsy may show nonspecific inflammatory infiltrates, various degrees of regenerative or degenerative changes, fatty infiltrates, and areas of focal necrosis (4, 7, 11).…”

Section: Materials and Resultsmentioning

confidence: 99%

Angiography of the Nephrogenic Hepatic Dysfunction Syndrome

Mena¹,

Bull²,

Bookstein³

et al. 1974

Radiology

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A hepatic dysfunction syndrome associated with hypernephroma occurs in the absence of hepatic metastatic disease. It is characterized by nonspecific constitutional symptoms, hepatomegaly, and abnormal liver function tests. Hepatic angiography in 3 cases demonstrated hepatomegaly, pronounced hypervascularity, and marked accentuation of hepatic granularity during the capillary phase, without focal defects or pathologic vessels to suggest metastases. Liver enlargement and biochemical abnormalities may regress after nephrectomy. Recognition of this syndrome is important to avoid misdiagnosis of metastatic disease which would result in inappropriate palliative therapy of the renal carcinoma.

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“…Nonendocrine tum ors are known to dem onstrate a wide range of hormone activity [1,3]. A num ber of cases of m alignant neoplasm have been reported, accompanied by hypercalcemia, with no evidence of bony métastasés or parathyroid gland alterations [6,7,10,12].…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia Associated with Vulvar Carcinoma

Buchsbaum¹

1969

Gynecol Obstet Invest

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A review of unusual systemic manifestations associated with carcinoma

Cited by 92 publications

References 113 publications

Pulmonary Tumor Emboli

Pulmonary Tumor Emboli

Angiography of the Nephrogenic Hepatic Dysfunction Syndrome

Hypercalcemia Associated with Vulvar Carcinoma

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