A review of typical PLD arrangements: Challenges, awareness, and solutions

Garrido, Juan Manuel Conde; Silveyra, Josefina María

doi:10.1016/j.optlaseng.2023.107677

Cited by 4 publications

(1 citation statement)

References 183 publications

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“…It also offers a wide range of versatility. MAPLE is a modification of the pulsed laser deposition (PLD) technique, − and it is particularly suitable for depositions of thermally labile complex organic molecules (enzyme, proteins, nucleic acids, encapsulated drugs − ), polymers (including polymer nanocapsules), and drugs. − MAPLE has also been applied to the deposition of graphene-related materials (GRMs) in thin films − with the advantages of tight contact to the target substrate and a good film uniformity, which are particularly desirable for biological applications where film stability in an aqueous medium is required . In a MAPLE experiment, a frozen suspension/solution (typically <2 wt %) is irradiated by a laser with suitable wavelength, and it sublimates in vacuum, bringing the solute to impact a given substrate while the solvent molecules are pumped away by the vacuum system.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Hybrid Graphenic Thin Coatings on Flexible Substrates through Matrix-Assisted Pulsed Laser Evaporation (MAPLE)

Alfe,

Minopoli,

Tartaglia

et al. 2024

ACS Appl. Mater. Interfaces

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This work reports the production of biocompatible thin layers for biomedical applications based on a graphene-like material (GL), a graphene-related material (GRM) obtained from carbon black. GL was combined in a hybrid fashion with polydopamine (pDA), a mussel-inspired water-resistant wet adhesive bonding obtained by the oxidative polymerization of dopamine (DA), and polyvinyl pyrrolidinone (PVP), a nontoxic synthetic polymer with intrinsic adhesion properties, to obtain a tighter adhesion of the thin layer to the substrate (silicone slices). Matrix-assisted pulsed laser evaporation (MAPLE) was used to coat PDMS slices with thin films of GL-pDA and GL-PVP directly from their frozen suspensions in water. The results indicate that the relevant chemical−physical characteristics of both thin films (evidenced by FTIR and AFM) were maintained after MAPLE deposition and that the films exhibit uniformity also at the nanometric level. After deposition, the GL-pDA and GL-PVP films underwent a biological survey toward murine fibroblasts (NIH3T3), human keratinocytes (HaCAT), and human cervical adenocarcinoma epithelial-like (HeLa) cells to assess the feasibility of this approach. Results indicate that both the GL-pDA and GL-PVP films did not perturb the biological parameters evaluated, including cytoskeleton alterations. Both hybrid films enhanced the effects of GL on cellular vitality across all cell lines. Specifically, the GL-pDA film exhibited a more stable effect over time (up to 72 h), whereas the GL-PVP film behaved similarly to the GL film in NIH3T3 and HeLa cell lines after long-term exposure. These promising results make the GL-pDA and GL-PVP films potential candidates for the manufacture of coated flexible devices for biomedical applications.

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