A review of Tunisian medicinal plants with anticancer activity

Wannes, Wissem Aidi; Tounsi, Moufida Saïdani; Marzouk, Brahim

doi:10.1515/jcim-2017-0052

Cited by 14 publications

(13 citation statements)

References 211 publications

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“…The use of these traditional plants has been targeting several diseases, from a common cold to cancer [3]. Contemporary research has validated several parts of plants from roots, stems, and leaves in potential medicinal preparations by screening for active ingredients such as plant metabolites [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition and health properties of Sembung plant (Blumea balsamifera): A review

Widhiantara

Jawi

2021

Vet World

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Indonesia's mindset has been focusing on the use of natural medicines, food, and healing practices widely recognized by the nation's culture. Traditional medicines and herbs used in traditional medicine can often lead to the discovery of drugs against certain diseases. The aim of this review was to study evidence-based data on the importance of Sembung plant, Blumea balsamifera, as a potential traditional medicine. The distribution, ethnopharmacology, secondary metabolites, and bioactivity against several diseases are focused in this review. Information and research related to Sembung plant were searched using the terms "B. balsamifera," "phytochemicals," and "pharmacological activity" on ResearchGate, Google Scholar, Science Direct, PubMed, and scientific information-based databases up to 2020. Several ethnomedical articles recommend B. balsamifera for the treatment of sinusitis, colic pain, cough, kidney stones, flu, or as a diuretic. This knowledge has already been applied in several countries in Southeast Asia. B. balsamifera has been reported to contain several phytochemicals both volatile (terpenoids, fatty acids, phenols, alcohol, aldehydes, ethers, ketones, pyridines, furans, and alkanes) and non-volatile (flavonoids, flavanones, and chalcones). Extracts and phytochemicals of B. balsamifera contain several biological capacities such as antioxidant, antimicrobial, antifungal, anti-inflammatory, hypolipidemic, anti-infertility, hepatoprotective activity, antidiabetic, gastroprotective, antitumor, anticancer, and immunomodulatory agent against Coronavirus disease-19 infection. This review provides essential data for the potential application of B. balsamifera as a nutraceutical or in future medicinal preparations.

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Section: Introductionmentioning

confidence: 99%

Phytochemical composition and health properties of Sembung plant (Blumea balsamifera): A review

Widhiantara

Jawi

2021

Vet World

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“…Since ancient times, Cistaceae have been used in ethnomedicine due to their pharmacological potential against a broad range of disorders, including various skin diseases, diarrhea, ulcers, dysentery, catarrh, menstruation difficulties, and gout due to a number of natural pharmacological compounds they consist of [ 2 , 3 , 4 ]. According to ethno-pharmacology, the Cistus species has been used due to its antimicrobial, antiproliferative, anticancer, antiviral, antioxidant, anti-inflammatory, antiulcerogenic, antidiarrheal, and antispasmodic activity [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. It is also known that some Cistus species have been used in human and animal diets, such as goats, lamb and beef [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

UPLC-MS/MS Phytochemical Analysis of Two Croatian Cistus Species and Their Biological Activity

Carev

Maravić

Ilić

et al. 2020

Life

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Aqueous extracts of two Cistus species wild growing in Croatia—Cistus creticus (CC) and Cistus salviifolius (CS)—have been assessed with UPLC-MS/MS, showing 43 different phytochemicals, with flavonol glycosides: myricetin-3-hexoside and myricetin-rhamnoside, predominate ones in CC and myricetin-3-hexoside in CS. Antioxidant potential tested with the FRAP method showed no difference between CS and CC aqueous extracts, while higher phenolic content of CC comparing to CS, determined with a Folin–Cicolateu reagent correlated to its higher antioxidant capacity observed by the DPPH method. Both extracts were assessed for antimicrobial activity, using disc-diffusion and broth microdilution assays, targeting the opportunistic pathogens, associated with food poisoning, urinary, respiratory tract, blood stream and wound infections in humans. Antimicrobial assays revealed that fungi were in general more sensitive to both Cistus aqueous extracts, comparing to the bacteria where two extracts showed very similar activity. The most potent activity was observed against A. baumannii for both extracts. The extracts were tested on human lung cancer (A549) cell line using the MTT assay, showing very similar antiproliferative activity. After 72 h treatment with CC and CS aqueous extracts in concentration of 0.5 g/L, the viability of the cells were 37% and 50% respectively, compared to non-treated cells.

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“…Globally, nearly 1 in 6 deaths is due to cancer (World Health Organization, 2014, World Health Organization, 2017). Approximately 70% of deaths from cancer occur in low- and middle-income countries (Aidi Wannes et al, 2017, World Health Organization, 2014, World Health Organization, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia

Mothana

Khaled

El‐Gamal

et al. 2019

Saudi Pharmaceutical Journal

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Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst. ex Benth., P. asirensis JRI Wood and P. barbatus Andrews. Moreover, this work focused on the isolation of the active constituents responsible for the activities from the most active Plectranthus species.The extracts were tested for their cytotoxic activity against three cancer cell lines (Hela, HepG2 and HT-29), using MTT-test, antimicrobial activity against Gram positive, Gram negative bacterial and fungal strains using broth micro-dilution assay for minimum inhibitory and bactericidal concentrations (MIC and MBC) and antioxidant activity using scavenging activity of DPPH radical and β-carotene-linoleic acid methods. The ethanolic extracts of the Plectranthus species showed remarkable cytotoxic activity against all cancer cell lines with IC50 values ranging between 10.1 ± 0.33 to 102.6 ± 8.66 μg/mL and a great and antimicrobial activity with MIC values between 62.5 and 250 µg/mL. In addition, the three Plectranthus species showed almost moderate antioxidant activity. The most interesting cytotoxic and antimicrobial results were observed with the extract of P. barbatus. Consequently, this extract was partitioned between water and n-hexane, chloroform and n-butanol and tested. The cytotoxic activity resided predominantly in the n-hexane and chloroform fractions. The analysis of the chloroform fraction led to the isolation of four diterpenoid compounds, two of labdane- and two of abietane-type, which were identified as coleonol B, forskolin, sugiol and 5,6-dehydrosugiol. Purification of the n-hexane fraction led to isolation of a major abietane-type diterpene, which was identified as ferruginol. Sugiol, 5,6-dehydrosugiol and ferruginol were isolated for the first time from P. barbatus in this study. The isolated diterpenoids showed variable cytotoxic effects with IC50 values between 15.1 ± 2.03 and 242 ± 13.3 µg/mL, a great antimicrobial activity with MIC values between 15.6 and 129 µg/mL and a total antioxidant activity ranging from 23.1 ± 2.9 to 69.2 ± 3.8%.

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A review of Tunisian medicinal plants with anticancer activity

Cited by 14 publications

References 211 publications

Phytochemical composition and health properties of Sembung plant (Blumea balsamifera): A review

Phytochemical composition and health properties of Sembung plant (Blumea balsamifera): A review

UPLC-MS/MS Phytochemical Analysis of Two Croatian Cistus Species and Their Biological Activity

Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia

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