A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights

Li, Xing; Liu, Kaida; Xing, Lidong; Rubinsky, Boris

doi:10.2478/raon-2023-0044

Cited by 4 publications

(2 citation statements)

References 82 publications

(143 reference statements)

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“…Currently, TTFields have been approved by FDA for treating patients with glioblastoma (both recurrent and newly diagnosed) and MPM 44 . As scientometric analysis showed, research on TTFields mainly focuses on cancer treatment, especially the treatment of glioblastoma (both recurrent and newly diagnosed) or malignant glioma.…”

Section: Discussionmentioning

confidence: 99%

Advancements and current trends in tumor treating fields: a scientometric analysis

Xing,

Yasinjan,

Cui

et al. 2024

International Journal of Surgery

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Tumor treating fields (TTFields) therapy is a novel and effective non-invasive cancer therapy, and it has been approved by FDA in the treatment of recurrent and newly diagnosed glioblastoma, and malignant pleural mesothelioma. Moreover, TTFields therapy has been widely studied in both clinical trials and preclinical studies in recent years. Based on its high efficacy, research on TTFields therapy has been a hot topic. Thus, we made this scientometric analysis of TTfields to reveal the scientometric distributions such as annual publications and citations, countries and institutions, authors, journals, references, and more importantly, research status and hot topics of the field. In recent years, publication numbers have been stable at high values, and citation numbers have been increasing greatly. The United States and Israel were the top two countries with the highest publication numbers, followed by Germany and Switzerland. Scientometric analyses of keywords indicated that clinical applications and antitumor mechanisms are probably the two main parts of current research on TTfields. Most clinical trials of TTfields focus on the treatment of glioblastoma. And a variety of other cancers such as lung cancer especially non-small cell lung cancer, hepatic cancer, other brain tumors, etc. have also been studied in both clinical trials and preclinical studies.

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Section: Discussionmentioning

confidence: 99%

Advancements and current trends in tumor treating fields: a scientometric analysis

Xing,

Yasinjan,

Cui

et al. 2024

International Journal of Surgery

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“…Also, TTFields have been used for treating different cancers by combining with chemotherapeutics. [30,31] Recently, the effects of oriented external electric fields (OEEFs) [32,33] on the structural and electronic properties of cisplatin have been studied by our group to understand the improved antitumor efficiency of cisplatin in the electrochemotherapy. [34] Based on the above facts, one interesting question emerges: Is it possible to tune the thiol-reactivity of above-mentioned complex 1 by exerting OEEFs on it?…”

Section: Introductionmentioning

confidence: 99%

Cyclometalated gold(III)‐hydride under oriented external electric fields: a new strategy to modulate its reactivity?

Li,

Cheng,

Jiang

et al. 2023

Chemistry A European J

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Selected gold complexes have been regarded as promising anti‐cancer agents because they can bind with protein targets containing thiol or selenol moieties, but their clinical applications were hindered by the unbiased binding towards off‐target thiol‐proteins. Recently, a novel gold(III)‐hydride complex (abbreviated as 1) with visible light‐induced thiol reactivity has been reported as potent photo‐activated anticancer agents (Angew. Chem. Int. Ed., 2020, 132, 11139). To explore new strategies to stimuli this potential antitumor drug, the effect of oriented external electric fields (OEEFs) on its geometric structure, electronic properties, and chemical reactivity was systematically investigated. Results reveal that imposing external electric fields along the Au−H bond of 1 can effectively activate this bond, which is conducive to its dissociation and the binding of Au site to potential targets. Hence, this study provides a new OEEF‐strategy to activate this reported gold(III)‐hydride, revealing its potential application in electrochemical therapy. We anticipate this work could promote the development of more electric field‐activated anticancer agents. However, further experimental research should be conducted to verify the conclusions obtained in this work.

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Synergistic effects of combined hyperthermia and electric fields treatment in non-small cell lung-cancer (NSCLC) cell lines

Heo,

Jo,

Yoon

2024

Clin Transl Oncol

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A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights

Cited by 4 publications

References 82 publications

Advancements and current trends in tumor treating fields: a scientometric analysis

Advancements and current trends in tumor treating fields: a scientometric analysis

Cyclometalated gold(III)‐hydride under oriented external electric fields: a new strategy to modulate its reactivity?

Synergistic effects of combined hyperthermia and electric fields treatment in non-small cell lung-cancer (NSCLC) cell lines

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