A review of trabeculectomy in East Asian people—the influence of race

Husain, Rahat; Clarke, Jonathan; Seah, S.K.W.; Khaw, PT

doi:10.1038/sj.eye.6701477

Cited by 52 publications

(46 citation statements)

References 97 publications

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“…1 It continues to outperform both medical and laser treatment in this regard, 2,3 especially in Africans where availability of and compliance with topical therapy are limited. 4 Also, trabeculectomy has been reported to be more beneficial in Africans in term of IOP lowering effect and slowing down of field loss.…”

Section: Introductionmentioning

confidence: 99%

Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up

Ashaye

Komolafe

2007

Eye

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Objective To describe the post-operative complications reported in patients who had trabeculectomy with and without antimetabolite in UCH, Ibadan between 1999 and 2003 and the success rate achieved in term of the post-operative intraocular pressure (IOP). Methods A retrospective study of the records of glaucoma patients who had trabeculectomy between 1999 and 2003 and had follow-up in UCH Ibadan eye clinic for a minimum of 1 year was carried out. Results Seventy-six out of 171 eyes that had trabeculectomy during the period were reviewed. Mean age of patients was 49.4 years. The mean preoperative IOP was 31.8 mm Hg. Success rate of 79.4% was achieved in term of IOP control at a year of follow-up. The most frequent early post-operative complication was shallow AC (13 eyes; 17.1%) while late complication was elevated IOP (21 eyes; 27.6%). Others were encapsulated bleb 7.9% and hyphema 3.9%. There was no significant difference in the complication rate in those who had intraoperative antimetabolite (5-fluorouracil) when compared with those operated without antimetabolite. Conclusion Guarded filtration surgery is effective in controlling IOP. Most of the complications noted were transient and not visually threatening.

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Section: Introductionmentioning

confidence: 99%

Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up

Ashaye

Komolafe

2007

Eye

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“…As Asian subjects are less responsive to trabeculectomy, the differences between Caucasians and Asians may explain the different intercept value. 14 In the current study, the 6-month postoperative IOPs after nonfi ltering surgery were characterized by their dependence on the preoperative IOP level and were clearly different from those after fi ltering surgery (Table 3). With Lectomy-MMC, the fi nal IOP in this study was independent of the preoperative baseline IOP and was consistently around 14.1 mmHg, a fi nding concordant with the results of previous studies wherein the 6-month postoperative IOP after successful trabeculectomy did not depend on the preoperative IOP levels and ranged from 12 to 14 mmHg.…”

Section: Discussionmentioning

confidence: 95%

“…12 Thus, the size of the fi stula may not be important, while, other parameters such as bleb size, wall thickness, vascularity of the bleb wall, or the presence of the intrableb connective tissue may be parameters of importance. 13,14 This may be the reason why the postoperative IOP after Lectomy MMC is independent of the preoperative IOP. The outcome of nonfi ltering surgery, on the other hand, may be a function of the surgically modulated trabecular meshwork and collector channel, and the facility of the emisarial pathway via the scleral fl ap.…”

Section: Discussionmentioning

confidence: 96%

Different modes of intraocular pressure reduction after three different nonfiltering surgeries and trabeculectomy

Chihara¹,

Hayashi²

2011

Jpn J Ophthalmol

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“…Thus far, the effect of racial difference on surgical failure after tube surgery has not yet been reported. A review by Husain et al19 mentioned that trabeculectomy with antimetabolites in an East Asian population was associated with a lower success rate and a higher complication rate than in other populations.…”

Section: Step 4 the Following Step Is “Applying Evidence For Actumentioning

confidence: 99%

Evidence-based medicine in glaucoma surgery

Kiuchi

2016

Taiwan Journal of Ophthalmology

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Evidence-based medicine (EBM) is a tool and guide for performing effective medical treatment. Here, as an example, EBM was applied to determine which between trabeculectomy and Baerveldt implant surgery would be more effective in a patient with a history of open-angle glaucoma. First, the author asked answerable clinical questions. Second, evidence using general search engines, such as the Cochrane Library or MEDLINE database, was collected. It was found that the Tube Versus Trabeculectomy (TVT) Study was a landmark study in determining optimum glaucoma surgical procedure. Third, the study's level of evidence was carefully examined. As the TVT Study was a prospective, randomized multicenter control study, its level of evidence was high. Fourth, the evidence to actual clinical decisions was applied, calculating the magnitude of the treatment effect using the results of the TVT Study. The event (surgical failure) rate in the control (trabeculectomy) and experimental (tube implant) groups (control event rate and experimental event rate, respectively) was obtained and the absolute risk reduction (ARR) was calculated by subtracting the experimental event rate from the control event rate. The inverse of ARR is the number needed to treat (NNT), which is the number of patients who must be treated to prevent a bad outcome. Using this method, it is possible to calculate the absolute risk (adverse event) increase (ARI) and the number needed to harm one more patient (NNH = 1/ARI). The balance of NNT and NNH is called the “likelihood of being helped and harmed.” The practice of EBM integrates clinical expertise of individuals with the best available external clinical evidence from systematic research.

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A review of trabeculectomy in East Asian people—the influence of race

Cited by 52 publications

References 97 publications

Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up

Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up

Different modes of intraocular pressure reduction after three different nonfiltering surgeries and trabeculectomy

Evidence-based medicine in glaucoma surgery

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