A review of the traditional use of southern African medicinal plants for the treatment of selected parasite infections affecting humans

Cock, Ian Edwin; Selesho, M.I.; Vuuren, Sandy van

doi:10.1016/j.jep.2018.04.001

Cited by 49 publications

(23 citation statements)

References 68 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From those studies, a further trend was also evident: decoctions and infusions were most widely used in the treatment of bacterial respiratory infections, with 64 plant-based medicines reported to be used in these ways. Previous studies have also reported that decoctions and infusions are the most common methods for treating most pathogenic diseases ( Afolayan et al, 2014 ; Asong et al, 2019 ; Cock et al, 2018 ; Cock et al, 2019 ; De Beer and Van Wyk, 2011 ; Hulley and Van Wyk , 2017; Nortje and Van Wyk, 2011; Philander, 2011 ). Tinctures were prepared and consumed for a further four species, volatiles targeted from three species via inhalation, and a syrup was prepared and consumed from the fruit of various species.…”

Section: Resultsmentioning

confidence: 99%

“…2 ). Interestingly, leaves are also the most frequently used plant part for the treatment of many other pathogenic diseases ( Afolayan et al, 2014 ; Asong et al, 2019 ; Cock et al, 2018 ; Cock et al, 2019 ; De Beer and Van Wyk, 2011 ; Hulley and Van Wyk , 2017; Philander, 2011 ). The roots of 58 plant species were also used to treat several bacterial respiratory diseases, whilst bark (15 species) and stems and twigs (10 species) were also relatively widely used.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Cock

Vuuren

2020

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance Multiple plant species were used traditionally in southern Africa to treat bacterial respiratory diseases. This review summarises this usage and highlights plant species that are yet to be verified for these activities. Aim of the study This manuscript reviews the traditional usage of southern African plant species to treat bacterial respiratory diseases with the aim of highlighting gaps in the literature and focusing future studies. Materials and methods An extensive review of ethnobotanical books, reviews and primary scientific studies was undertaken to identify southern African plants which are used in traditional southern African medicine to treat bacterial respiratory diseases. We also searched for southern African plants whose inhibitory activity against bacterial respiratory pathogens has been conmfirmed, to highlight gaps in the literature and focus future studies. Results One hundred and eighty-seven southern African plant species are recorded as traditional therapies for bacterial respiratory infections. Scientific evaluations of 178 plant species were recorded, although only 42 of these were selected for screening on the basis of their ethnobotanical uses. Therefore, the potential of 146 species used teraditionally to treat bacterial respiratory diseases are yet to be verified. Conclusions The inhibitory properties of southern African medicinal plants against bacterial respiratory pathogens is relatively poorly explored and the antibacterial activity of most plant species remains to be verified.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Cock

Vuuren

2020

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…and Diels, Vernonia amygdalina, Ximenia americana L. var. americana, and Ximenia caffra Sond [77][78][79][80][81].…”

Section: Plants Traditionally Used Against Schistosomiasismentioning

confidence: 99%

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

Albuquerque

Mahomoodally

Lobine

et al. 2020

Biology

View full text Add to dashboard Cite

Schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma, is the second most prevalent parasitic disease in the world. It affects around 200 million people. Clinical treatment, prophylaxis, and prevention are performed in countries susceptible to schistosomiasis. In the pharmacological treatment for an acute form of schistosomiasis, the use of antiparasitics, mainly praziquantel, is more common. As an alternative way, prevention methods such as reducing the population of intermediate hosts (mollusks) with molluscicides are important in the control of this disease by interrupting the biological cycle of this etiological parasite. Despite the importance of pharmacological agents and molluscicides, they have side effects and environmental toxicity. In addition, they can lead to the development of resistance enhancing of parasites, and lead to the search for new and effective drugs, including resources of vegetal origin, which in turn, are abundant in the affected countries. Thus, the purpose of this review is to summarize recent studies on botanical products with potential for the control of schistosomiasis, including anti-Schistosoma and molluscicide activities. In addition, species and plant derivatives according to their origin or geographical importance indicating a possible utility of local resources for countries most affected by the disease are presented.

show abstract

“…Clinicamente, a leishmaniose apresenta-se nas formas cutânea e mucocutânea resultando em lesões superficiais e, na forma visceral ataca os orgâos internos podendo levar a óbito. 27 A ausência de vacinas e a toxicidade dos medicamentos atualmente usados para tratar a leishmaniose impulsiona a busca por novas substâncias ativas provenientes de plantas. 27 Dessa forma, considerando a ocorrência de atividade antileishmania em plantas da família Rubiaceae, 6 30 e mistura de sitosterol e estigmasterol (CI 50 =70±0 μg mL -1 ), 31 os quais foram testados frente a L. amazonensis.…”

Section: Atividade Antileishmaniaunclassified

COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTILEISHMANIA DE Tocoyena hispidula

et al. 2018

View full text Add to dashboard Cite

CHEMICAL COMPOSITION AND ANTI-LEISHMANIA ACTIVITY FROM Tocoyena hispidula. Phytochemical investigation of the CHCl 3 fraction from EtOH extract of Tocoyena hispidula (Rubiaceae) stem resulted in the isolation and identification of D-(+)-mannitol, lupenone, 3-O-acetyloleanolic acid, lapachol, dimethyl chelidonate, morindolide and four mixtures (M1-M4): M1 (palmitate, margarate, linoleate, oleate e stearate of the multiflorenyl, lupeyl, sitosteryl and stigmasteryl), M2 (lupeol, taraxerol, germanicol, β-amyrin and E-fitol), M3 (campesterol, campestanol, stigmasterol, Δ 22-stigmastenol, sitosterol and sitostanol) and M4 (7-ketositosterol and 7-ketostigmasterol). Structural identification of the compounds was performed by analysis 1 H and 13 C NMR spectra and by GC-MS. Extract, fractions, dimethyl chelidonate and morindolide inhibited the growth of Leishmania major promastigotes, being the CHCl 3 (IC 50 = 26.25 μg mL-1) and EtOAc (IC 50 = 29.77 μg mL-1) fractions the more active.

show abstract

A review of the traditional use of southern African medicinal plants for the treatment of selected parasite infections affecting humans

Cited by 49 publications

References 68 publications

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTILEISHMANIA DE Tocoyena hispidula

Contact Info

Product

Resources

About