“…Besides UV protection, an optimized skin care regimen in combination with trifarotene is critical to support the skin barrier, which is often impaired in both treated dry and untreated lipid-rich acne skin (Figure 1). Also, in this issue, See et al 5 bring a new perspective to acne management, focusing on topical retinoid-based treatments by highlighting factors specific to different regions of the world. Using the example of acne patients from the Asia-Pacific region, whose skin has a thinner stratum corneum, higher eccrine gland activity, and a less effective barrier to sensitizing or irritating substances, coupled with the use of region-specific skin care products and cultural preferences for a lighter skin phenotype, they suggest improving and harmonizing regional acne guidelines.…”