A Review of the Properties and Processes Determining the Fate of Engineered Nanomaterials in the Aquatic Environment

Peijnenburg, Willie J.G.M.; Baalousha, Mohammed; Chen, Jingwen; Chaudry, Qaiser; Kammer, Frank von der; Kuhlbusch, Thomas A. J.; Nickel, Carmen; Quik, J.T.K.; Renkerg, M.; Koelmans, Albert A.

doi:10.1080/10643389.2015.1010430

Cited by 176 publications

(104 citation statements)

References 221 publications

(276 reference statements)

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“…Oyster larvae are evidently able to process internalized NPs and eject them (via excretion and diapedesis). Acidic pH and low electrolyte concentrations such as are found within the cellular digestive system can reverse the aggregation of NPs and the adsorption of seawater ions from their surface, typical transformations occurring in the marine environment which can mitigate the toxicological potential of many NPs (Peijnenburg et al, 2015). The endo-lysosomal system of the molluscan digestive gland is a noted target of aquatic pollutants, sensitive to a variety of environmental stressors and xenobiotics that are taken up by digestive cells and bioaccumulated (Marigómez et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

et al. 2018

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The biological fate of nanoparticles taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron microscopy and energy dispersive X-ray spectroscopy (TEM-EDS), we describe the key aspects that characterize the interaction between an aquatic organism of global ecological and 2 economic importance, the early larval stage of the Japanese oyster (Crassostrea gigas), and model gold nanoparticles dispersed in their environment. The small size of the model organism allowed for a high-throughput visualization of the subcellular distribution of nanoparticles, providing a comprehensive and robust picture of the route of uptake, mechanism of cellular permeation, and the pathways of clearance counterbalancing bioaccumulation. We show that nanoparticles are ingested by larvae and penetrate cells through alimentary pinocytic/phagocytic mechanisms. They undergo intracellular digestion and storage inside residual bodies, before excretion with feces or translocation to phagocytic coelomocytes of the visceral cavity for potential extrusion or further translocation. Our mechanistically-supported findings highlight the potential of oyster larvae and other organisms which feature intracellular digestion processes to be exposed to manmade nanoparticles and thus any risks associated with their inherent toxicity.

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Section: Discussionmentioning

confidence: 99%

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

et al. 2018

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“…For instance, the recent development of single particle-inductively coupled plasma-mass spectrometry (sp-ICP-MS) enables measuring NPs at environmentally relevant concentrations; however, the poor lower size detection limit (,10-400 nm depending on NP composition) is likely to be a limiting factor when investigating small NPs. [8] While the environmental fate and behaviour of NPs may depend on solution media characteristics and the physicochemical properties of NPs such as size, shape and crystal structure, [9] we focus here on NP concentration because it is the parameter that has been widely overlooked in the literature because of multiple analytical challenges. Several studies have illustrated the dominant role of NP aggregation and dissolution in controlling their environmental behaviour, but, to our knowledge, few published studies have investigated the effect of NP concentration on dissolution and aggregate size in the milligram per litre NP concentration range.…”

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confidence: 99%

The concentration-dependent behaviour of nanoparticles

et al. 2016

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Environmental context. Studies of manufactured nanoparticles (NPs) in the environment have been performed almost exclusively at high NP concentrations. These data lead to misunderstandings related to NP fate and effects at relevant environmental concentrations, which are expected to be low. A better understanding of the concentration-dependent behaviour of NPs will improve our understanding of their fate and effects under environmentally realistic conditions.Abstract. This rapid communication highlights the importance of nanoparticle concentration in determining their environmental fate and behaviour. Notably, two fate processes have been considered: dissolution and aggregation. The decrease in nanoparticle concentration results in increased dissolution and decreased aggregate sizes, inferring higher potential for environmental transport of nanoparticles. The behaviour (e.g, dissolution, aggregation, disaggregation) and fate (e.g. mobility, fugacity, non-transient (sink) or transient source) of nanoparticles (NPs) in environmental and toxicological media have been investigated for over a decade, typically at high NP concentrations (e.g. milligram per litre range) which are not relevant to the environment, [1] resulting in some potentially misleading assumptions that (i) NP behaviour is dominated by aggregation and thus their fate is dominated by sedimentation and removal from the water column, or, in porous media, deposition and removal from the aqueous phase [2] ; (ii) NP dissolution is limited for many NPs and rarely are all NPs dissolved fully in environmental and biological media over relevant timescales [1] and (iii) many NPs therefore impart little or no toxic risk to pelagic organisms as a result of limited NP dissolution and NP removal by aggregation and sedimentation. [3] Several NP groups (e.g. Ag NPs, Cu NPs, Cd NPs, ZnO) may undergo dissolution and release ions with well known toxic effects. [4] These various issues complicate NP risk characterisation and are exacerbated by the general use of high NP concentrations in NP fate, behaviour and ecotoxicological studies. [2,5] Use of high NP concentrations has been motivated by poor detection limits of available analytical techniques (e.g. dynamic light scattering, laser Doppler electrophoresis, UV-Vis spectroscopy) together with enhanced likelihood of observing more pronounced changes and effects at high NP concentrations. [6] Furthermore, most published nanoecotoxicological data are acute exposure studies, which also drive the high concentration selection bias in order to generate measurable biological responses. Many NPs tested for toxicity to aquatic organisms have been non-toxic on acute time scales until they reach unrealistically high exposure concentrations. Clear predictive linkages between unrealistic high acute exposures and more realistic low chronic exposures have not been established for aquatic systems, and are likely to be further complicated by differing concentration-dependent behaviours of NPs.Despite these concerns, little attention ha...

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“…Such research is useful to policy makers, who are slowly concluding that current regulations on chemicals is not satisfactory for governance of nanomaterials [2,3]. It is however, important to note that only a relatively small number of studies or reviews of nanomaterials' effects on the environment has been found [4][5][6][7][8][9][10][11][12][13][14][15]. This is despite the fact that health can be affected both when handling the material (i.e.…”

Section: Introductionmentioning

confidence: 93%

A framework for health-related nanomaterial grouping

Gkika

Nolan

Vansant

et al. 2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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The risk analysis validated the impression that there is limited research on nanomaterial toxicity risks, which calls for a more organized approach. The framework outlined in this work can be utilized by researchers as well as government bodies, in order to form regulatory policies and adopt a universally accepted labeling system. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editor: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

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A Review of the Properties and Processes Determining the Fate of Engineered Nanomaterials in the Aquatic Environment

Abstract: Proper understanding of the basic processes and specific properties of engineered nanomaterials (NMs) that modify the fate and effects of NMs is crucial for NM

Cited by 176 publications

References 221 publications

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

The concentration-dependent behaviour of nanoparticles

A framework for health-related nanomaterial grouping

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