A review of the possible mechanisms for the persistence of foot-and-mouth disease virus

Woodbury, E. L.

doi:10.1017/s0950268800051864

Cited by 47 publications

(29 citation statements)

References 69 publications

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“…At this stage, it also include linking, cannot eat and move. Other signs include licking of the feet or shifting weight from one leg to other, holding one hoof off the ground, lagging behind the herd, lying down and reluctance to rise (Woodbury, 1995). Vesicles may also be seen on the teats of lactating animals.…”

Section: Introductionmentioning

confidence: 99%

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A study on sero prevalence of foot and mouth diseases in West and South West Shoa zones of Oromia regional state, central Ethiopia

Hordofa¹,

Chibsa²,

Kasaye³

2018

J. Vet. Med. Anim. Health

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Cross-sectional study was conducted from December, 2008 to April, 2009 to determine the sero prevalence of foot and mouth disease (FMD) virus in West and South West Shoa zones of Oromia regional state, central Ethiopia. The samples were processed with the 3 ABC ELISA kits that can able to identify natural infected animal from vaccinated animals. From the total sera of 421 tested, the overall sero prevalence of FMD in cattle was 15.0% (63/421). The prevalence rate was higher (22%) in the South west shoa zone than West shoa zone (5.6%). The difference was statistically significant (ρ<0.05). At district level, the highest sero prevalence were recorded at Dawo (26.7%), Alemgana (26.2%), Kokir (24.4%) and Haramaya (21.4%) districts, which were located at south west shoa zone. The difference among districts were statistically significant (ρ<0.05). Statistically difference was also observed between different age groups (ρ<0.05); being higher in adult (19.3%) followed by calves (9.3%). The sero prevalence of male and female were 16.0 and 14.1%, respectively, and which was not statistically significant (ρ>0.05). The sero prevalence of FMD was found higher in mid highland (16.8%) than highland attitude (6.7%) which was statistically significant (ρ<0.05). The result of this study indicated that FMD is highly prevalent in the South West Shoa zone than West Shoa zone due to contact of different origin of animals, and free animals movement in search of feed and water in zone. Age and attitude were also found as an important risk factor for the diseases. Finally, it is recommended that, sero typing of the virus circulating in the study area should be undertaken for effective control of the disease.

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Section: Introductionmentioning

confidence: 99%

“…Vesicles may also be seen on the teats of lactating animals. Morbidity is high and young caves may die before the appearance of clinical signs due to virus infection of the developing heart muscle and the production of a severe myocarditis (Woodbury, 1995). However, most animal recover within 2 weeks.…”

Section: Introductionmentioning

confidence: 99%

A study on sero prevalence of foot and mouth diseases in West and South West Shoa zones of Oromia regional state, central Ethiopia

Hordofa¹,

Chibsa²,

Kasaye³

2018

J. Vet. Med. Anim. Health

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“…Such animals, in which live viruses can be isolated from oropharyngeal fluid more than 28 days after infection, are defined as ''carriers'' [45,48,49,52]. Several studies have implicated pharyngeal tissues as a site of persistence in cattle.…”

Section: Introductionmentioning

confidence: 99%

Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

et al. 2015

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In addition to acute infection and disease, foot-and-mouth disease virus (FMDV) can cause persistent infection in ruminants. Such "carrier" animals represent a potential risk for FMDV transmission to susceptible animals. However, the mechanisms and the factors that determine FMDV persistence remain unknown. We describe here the establishment of FMDV type O persistent infection in a bovine epithelial cell line (Madin-Darby bovine kidney; MDBK). Preliminary experiments to assess the permissivity of MDBK cells to FMDV O infection revealed an unusual pattern of infection: after the initial phase of acute cell lysis, new monolayers formed within 48-72 h post-infection. We found that some cells survived cytolytic infection and subsequently regrew, thereby demonstrating that this bovine cell line can be persistently infected with FMDV type O. Further evidence that MDBK cells were persistently infected with FMDV includes: (i) detection of viral RNA in cells as well as in cell culture supernatants, (ii) detection of viral antigens in the cells by immunofluorescence analysis, and (iii) production of infectious viral particles for up to 36 cell passages. Furthermore, preliminary sequence analysis of persistent virus revealed a single nucleotide substitution within the VP1 coding region, resulting in the V50A amino acid substitution. This bovine model of FMDV persistence holds promise for the investigation of the viral and cellular molecular determinants that promote FMDV persistence.

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“…From the quasispecies pool of genomes, variant populations are selected, either in the presence [16] or absence of immune pressure [17]. Genetic variants also arise during persistent infection of animals [18,19] or during propagation in cell culture [20]. In addition to the above mechanisms, genetic diversification in FMDV can be attributed to recombination events either between intratype and intertype [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Molecular relationships between type Asia 1 new strain from China and type O Panasia strains of foot-and-mouth-disease virus

et al. 2007

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The complete genome of Asia 1/HNK/CHA/05 strain of foot-and-mouth disease virus (FMDV) was sequenced, which was isolated from Chinese Hongkong in 2005. It is 8187 nt long in size and contains 5'-UTR, polyprotein region, and 3'-UTR. Polyprotein region can be divided into four parts of L, P1, P2 and P3. In this report, these six parts of the whole genome of the strain were compared with 12 reference strains using DNAStar and Simplot softwares. The comparison of P1 confirmed that Asia 1/HNK/CHA/05 has a high identity with nine type Asia 1 reference sequences from 85.9 to 92.6% (Ind/491/97 strain is the highest) but from 69.6 to 69.7% with three type O Panasia sequences. The identities of 5'-UTR, L, P2, P3 and 3'-UTR with three Panasia strains are from 89.0 to 90.6%, 92.5 to 93.4%, 94.8 to 95.5%, 96.0 to 96.7% and 90.7 to 92.5% separately, but with nine type Asia 1 strains are from 83.5 to 85.9%, 87.7 to 90.7%, 87.0 to 91.6%, 91.6 to 92.8% and 86.0 to 100% separately, which illuminates the closer relationship between Asia 1/HNK/CHA/05 and Panasia strains in 5'-UTR, L, nonstructural region and 3'-UTR although they do not belong to the same serotype. The SimPlot software was used to examine the authentic relationships of Asia 1/HNK/CHA/05 with 12 reference sequences. It was found that Asia 1/HNK/CHA/05 strain has a highest similarity with three Panasia strains especially Tibet/CHA/99 in 5'-UTR, L, nonstructural region and 3'-UTR but has a highest similarity with Asia 1/Ind/491/97 strain in P1 region, which suggested that the gene recombination had occurred around nucleotide position 1811 and 3971in the polyprotein region between Tibet/CHA/99 and Ind/491/97 to recombine the Asia 1/HNK/CHA/05 strain.

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A review of the possible mechanisms for the persistence of foot-and-mouth disease virus

Cited by 47 publications

References 69 publications

A study on sero prevalence of foot and mouth diseases in West and South West Shoa zones of Oromia regional state, central Ethiopia

A study on sero prevalence of foot and mouth diseases in West and South West Shoa zones of Oromia regional state, central Ethiopia

Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells

Molecular relationships between type Asia 1 new strain from China and type O Panasia strains of foot-and-mouth-disease virus

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