A review of the pharmacological and therapeutic effects of auraptene

Abstract

There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7‐geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated from Citrus aurantium (Seville orange) and Aegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell growth, and apoptosis. It has a potential therapeutic role in the prevention and treatment of various diseases due to its anti‐inflammatory and antioxidant activities as well as its excellent safety profile. In the present article, various pharmacological and therapeutic effects of auraptene were reviewed. Different online databases using keywords such as auraptene, therapeutic effects and pharmacological effects were searched until the end of September 2018, for this purpose. Auraptene has been suggested to be effective in the treatment of a broad range of disorders including inflammatory disorders, dysentery, wounds, scars, keloids, and pain. In addition, different studies have demonstrated that auraptene possesses numerous pharmacological properties including anti‐inflammatory, anti‐oxidative, anti‐diabetic, anti‐hypertensive and anti‐cancer as well as neuroprotective effects. The present review provides a detailed survey of scientific researches regarding pharmacological properties and therapeutic effects of auraptene.

From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke

“…For example, auraptene, a citrus coumarin endowed with anti-inflammatory properties [299], acts as neuroprotective agent in the 2VO mouse model of brain ischemia by inhibiting inflammation [300,301].…”

Auraptene and umbelliprenin: a review on their latest literature acquisitions

“…The only biochemical parameters recorded were common blood exam values, mostly expressing liver functionality, that in the treated group of volunteers interestingly were not significantly different from values recorded in the control one. To this context it is noteworthy how the only two studies reported in the literature about pharmacokinetic of auraptene are still represented by those obtained in animal models, namely dogs and rats, and published respectively by Yuan et al (2012) and Ye et al 2016, the details of which can be found in previously published review articles on auraptene (Bibak et al 2019;Genovese et al 2015). So, it is desirable that in the next future the pharmacokinetic profile of auraptene in humans could be traced to largely contribute to the determination to its safety for humans.…”

A Review of Auraptene as an Anticancer Agent

“…Auraptene is isolated from many of the edible fruits and vegetables of the genus Ferula and Citrus like lemons, grapefruits and oranges. Auraptene indicates a variety of therapeutic properties such as antidiabetic, antiprotozoal, anti-bacterial, anti-fungal, anti-genotoxic, antileishmanial, anti-inflammatory, antihelicobacter, and immunomodulatory activities ( Bibak et al, 2019 ). This compound showed significant effect on the treatment of several chronic illnesses including hypertension, nonalcoholic fatty liver and cystic fibrosis ( Derosa et al, 2016 ; Figure 1 ).…”