A review of the multifunctionality of angiopoietin-like 4 in eye disease

Yang, Xiongwen; Cheng, Yan; Su, Guanfang

doi:10.1042/bsr20180557

Cited by 37 publications

(37 citation statements)

References 130 publications

(131 reference statements)

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“…Several of these microorganisms have long been associated with complications in patients admitted to burn therapeutic centers (13,14). Recently, the effect of the angiopoietin-1 has been implicated in the healing of cerebral malaria (15) and eye diseases (16).…”

Section: Introductionmentioning

confidence: 99%

Wound healing potential: Evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part

Alipour

Shahriari-Namadi

Ebrahimi

et al. 2020

Preprint

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Abstract Objective: High prevalence of chronic ulcers and burden of disease necessitate the increasingly significant production of new recombinant proteins in the world. The angiopoietin-1 enzyme is a part of growth factors group which is secreted by Lucilia sericata (Diptera: Calliphoridae) larvae when they are exposed to wounds to ensure maggot therapy. It is one of the most potent proteins in wound healing. Given its essential role, angiopoietin-1 gene of L. sericata was characterized which provided some basic information on its identity. Results: The mid-part of angiopoietin-1 mRNA sequence was thus characterized based on the design of disparate primers such as exon-exon junction, conserved regions, and specific region primers via conventional polymerase chain reaction (PCR). Its structural features was configured by in silico method. The sequence of mid-part (390 bp) of angiopoietin-1 was determined empirically, and BLAST analysis unravelled its high identity (85%) with the sequence of angiopoietin-1 mRNA of the larval housefly, Musca domestica . The homology of this enzyme also exhibited that its nucleic acid sequence was very similar to the domains of angiopoietin-1 in Lucilia cuprina . The current data are critical to evaluate the action of this enzyme in recombinant protein production in future molecular studies on wound healing.

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Section: Introductionmentioning

confidence: 99%

Wound healing potential: Evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part

Alipour

Shahriari-Namadi

Ebrahimi

et al. 2020

Preprint

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“…We read the article by Yang et al [1] with great interest. The study assembled valuable information regarding regulatory effects of angiopoietin-like 4 (ANGPTL4)-associated pathways and provided information for the potential development of this protein as a clinical treatment target in eye disease therapy [1].…”

mentioning

confidence: 99%

“…In their article, Yang et al [1] used the terminologies ‘in aqueous’ and ‘ in vitro ’ referring to Jee et al [5] research regarding sickle cell retinopathy (SCR). Reading Yang et al study, we understood that Jee et al [5] performed a research outside a living organism [1].…”

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confidence: 99%

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Angiopoetin-like 4 in sickle cell retinopathy

Guerra

Bastos²,

Salles

2018

Bioscience Reports

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Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells

et al. 2022

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Head and neck cancer (HNC) is the seventh most common cancer worldwide, the majority being oral squamous cell carcinoma. Despite advances in cancer diagnosis and treatment, the survival rate of patients with HNC remains stagnant. The cancer-nerve interaction has been recognized as an important driver of cancer progression. Schwann cells, a type of peripheral glia, have been implicated in promoting cancer cell growth, migration, dispersion, and invasion into the nerve in many cancers. Here, it is demonstrated that the presence of Schwann cells makes oral cancer cells more aggressive by promoting their proliferation, extracellular matrix breakdown, and altering cell metabolism. Furthermore, oral cancer cells became larger, more circular, with more projections and nuclei following co-culturing with Schwann cells. RNA-sequencing analysis in oral cancer cells following exposure to Schwann cells shows corresponding changes in genes involved in the hallmarks of cancer and cell metabolism; the enriched KEGG pathways are spliceosome, RNA transport, cell cycle, axon guidance, signaling pathways regulating pluripotency of stem cells, cAMP signaling, WNT signaling, proteoglycans in cancer and PI3K-Akt signaling. Taken together, these results suggest a significant role for Schwann cells in facilitating oral cancer progression, highlighting their potential as a target to treat oral cancer progression.

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A review of the multifunctionality of angiopoietin-like 4 in eye disease

Cited by 37 publications

References 130 publications

Wound healing potential: Evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part

Wound healing potential: Evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part

Angiopoetin-like 4 in sickle cell retinopathy

Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells

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