A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma
ELHAM AMJAD,
RAFFAELE PEZZANI,
BABAK SOKOUTI
Abstract:Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient’s outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of… Show more
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