A Review of the Landscape of Targeted Immunomodulatory Therapies for Non-Infectious Uveitis

Sharma, Srilakshmi M; Fu, Dun Jack

doi:10.1007/s40123-017-0115-5

Cited by 12 publications

(12 citation statements)

References 96 publications

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“…IL-17A, a member of the IL-17 superfamily of cytokines, is known to play an important role in SpA manifestations related to the skin, joints and entheses, as reflected by the suppression of disease activity seen with IL-17A inhibitors in psoriasis, PsA and AS 12–19. However, in other settings where IL-17 family members have been found at sites of disease, such as gut inflammation and uveitis, IL-17A inhibition is not beneficial 20–22. These discrepant responses illustrate the need for clearer understanding of the aetiology of these inflammatory diseases, particularly the role of the IL-17 family in the context of the tissue(s) affected.…”

Section: Introductionmentioning

confidence: 99%

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

et al. 2019

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Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune responses mediated by interleukin 17A (IL-17A) play a pivotal role in both diseases. This is best highlighted by the significant clinical efficacy shown with inhibitors of IL-17A in treating axSpA and PsA. Nevertheless, a number of knowledge gaps exist regarding the role of IL-17A in the pathophysiology of spondyloarthritis in man, including its cellular origin, its precise role in discrete disease processes such enthesitis, bone erosion, and bone formation, and the reasons for the discrepant responses to IL-17A inhibition observed in certain other spondyloarthritis manifestations. In this review, we focus on the latest data from studies investigating the role of IL-17A in ankylosing spondylitis (AS) and PsA that build on existing and emerging scientific knowledge in the field. Key remaining research questions are also highlighted to guide future research.

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Section: Introductionmentioning

confidence: 99%

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

et al. 2019

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“…Uveitis (UVT) is a vision threatening inflammatory disease of the uveal tract (iris, ciliary body and choroid) and adjacent structures (retina, vitreous humor and optic nerve) of the eye. UVT is responsible for about 25% of blindness in the developing world [1] and affects people in the working age group (20-60 years) thus contributing to the socio-economic burden [2]. Generally, UVT is associated with either a systemic infection or an immunological disease.…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

et al. 2018

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Uveitis (UVT), an inflammatory disease of the eye significantly contributes to vision impairment and blindness. Uveitis is associated with systemic infectious and autoimmune diseases, but in most cases, the aetiology remains unidentified. Dysbiosis in the gut microbiome has been implicated in autoimmune diseases, inflammatory diseases, cancers and mental disorders. In a mice model of autoimmune UVT, it was observed that manipulating the gut microbiome reduces the inflammation and disease severity. Further, alterations in the bacterial gut microbiome and their metabolites were reported in UVT patients from a Chinese cohort. Hence, it is worth comparing the bacterial gut microbiome of UVT patients with that of healthy controls (HC) to ascertain whether dysbiosis of the gut microbiome has implications in UVT. Our analyses showed reduced diversity of several anti-inflammatory organisms including ,, , and members of Lachnospiraceae and Ruminococcaceae families, and enrichment of (proinflammatory) and (pathogenic) OTUs in UVT microbiomes compared to HC. In addition, decrease in probiotic and antibacterial organisms was observed in UVT compared to HC microbiomes. Heatmap and PCoA plots also indicated significant variations in the microbiomes of UVT versus HC. This is the first study demonstrating dysbiosis in the gut bacterial communities of UVT patients in an Indian cohort and suggests a role of the gut microbiome in the pathophysiology of UVT.

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“…[ 128 ] Recent biologicals, the therapeutic molecules, target selective signaling pathways, for example, the intracellular JAK/STAT pathway (Janus kinase/signal transducer activating pathway) which alters the effects of cytokines within the immune cells ( www.clinicalTrials.gov NCT02914561 ). [ 129 ] Tear profiling and AH sampling are promising fields for further research and to improve diagnostic accuracy. [ 115 ] Enormous research and larger studies are required to identify these biomarkers and unveil the pathogenesis of inflammtion in order to further improve diagnostic accuracy and treatment.…”

Section: Future Trendsmentioning

confidence: 99%

Interleukins and cytokine biomarkers in uveitis

Balamurugan

Das

Hasanreisoğlu

et al. 2020

Indian J Ophthalmol

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Interleukins and cytokines are involved in the pathogenesis of uveitis of heterogeneous origin. Understanding the basics of the ocular immune privilege is a fulcrum to discern their specific role in diverse uveitis to potentially translate as therapeutic targets. This review attempts to cover these elements in uveitis of infectious, noninfectious and masquerade origin. Insights of the molecular targets in novel therapy along with the vision of future research are intriguing.

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A Review of the Landscape of Targeted Immunomodulatory Therapies for Non-Infectious Uveitis

Cited by 12 publications

References 96 publications

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

Interleukins and cytokine biomarkers in uveitis

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