A Review of the Incidence of Colorectal Cancer in the Middle East

Al-Hurry, Ahmed Mohammed Ali Hussein; Rezaianzadeh, Abbas; Rahimikazerooni, Salar; Akool, Mohammad Abdzaid; Bahrami, Faranak; Shahidinia, Seyedeh Saeedeh; Pourahmad, Mahboobeh

doi:10.5812/acr.46292

Cited by 10 publications

(11 citation statements)

References 22 publications

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“…Eligibility for participation included: (1) Adult between the ages of 50-75 years (according to the CRC screening guidelines at the time of recruitment), (2) Identifies as Arab, (3) Moved to the US after the age of 12 years, (4) Lives in New York City, and (5) Has selfreported proficiency in either English, Arabic or both.…”

Section: Participantsmentioning

confidence: 99%

“…Colorectal Cancer (CRC) rates are increasing in a number of Arab countries and patients are being diagnosed at younger ages [3], as Arabs adopt a more Westernized diet, and with increasing rates of obesity [4,5]. In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed and the third leading cause of cancer-related death in both men and women [6].…”

Section: Introductionmentioning

confidence: 99%

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Associations with the Receipt of Colon Cancer Screening Among a Diverse Sample of Arab Americans in NYC

Ayash

Badreddine

Gatarny

et al. 2019

J Immigrant Minority Health

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Arab Americans (AA) face increased risk for colorectal cancer (CRC), the third leading cause of cancer-related death in the US, due to low utilization of preventative care and socioeconomic disparities. This study explores associations with the receipt of CRC screening among AA in New York City. A cross-sectional survey was conducted among 100 individuals attending religious and community organizations with interviewer-administered surveys in Arabic and English. Results from 100 participants showed they were more likely to complete CRC screening with a doctor recommendation (74%) and were more likely to get a recommendation with a high school education or higher (86%). Uninsured participants and those with public insurance were the least likely to complete screening. Those with a higher mean score in Spiritual Life/Faith (13.34 vs. 11.67) were less likely to complete screening. Findings suggest the need for culturally sensitive interventions to increase CRC screening rates among AA.

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Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations with the Receipt of Colon Cancer Screening Among a Diverse Sample of Arab Americans in NYC

Ayash

Badreddine

Gatarny

et al. 2019

J Immigrant Minority Health

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“…Colorectal cancer is ranked as the third most commonly diagnosed cancer among both sexes combined, and the second most common cause of cancer-related death. 1 Even though there is a relatively lower incidence among the Arab population, 1,2 colorectal cancer is still the second most common cancer among Gulf Corporation Council (GCC) states. 2 This mirrors the annual incidence of about 11.3% seen in the state of Qatar in 2018.…”

Section: Introductionmentioning

confidence: 99%

“…1 Even though there is a relatively lower incidence among the Arab population, 1,2 colorectal cancer is still the second most common cancer among Gulf Corporation Council (GCC) states. 2 This mirrors the annual incidence of about 11.3% seen in the state of Qatar in 2018. 3 Despite its adverse outcome, the natural history of the disease lends itself to interventions that could potentially alter some of its adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

<p>Knowledge, Attitude and Practice of Physicians Regarding Screening of Colorectal Cancer in Qatar: A Cross-Sectional Survey</p>

Mohamed

Parambil

Danjuma

et al. 2020

AMEP

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The aim of this study was to evaluate the rate of internal medicine residents' and faculties' (specialists and consultants) compliance to colorectal cancer screening in Hamad Medical Corporation (Doha, Qatar) and to identify barriers as well as facilitators that will assist in drawing up changes that would enhance physician-related cancer screening. Methods: A cross-sectional web-based survey was distributed among internal medicine physicians at three component hospitals of Hamad Medical Corporation (HMC); focusing on knowledge and practice of colorectal cancer screening, its barriers and facilitators. Chisquare and t-test statistics were used to draw conclusions where appropriate. Results: The response rate for the survey was 91% and over 75% of the survey respondents were postgraduate trainees. The majority (90.6%) of the physicians (n=144) mentioned that they would recommend colorectal cancer screening for their asymptomatic patients, though trainees tend to choose the correct modality of screening compared to the consultants, 86.21% vs 40.74%. Only 43.4% of the survey participants always to usually recommend screening to their patients in their clinics while only 29.4% do so for their inpatients. Even though there was no statistically significant difference among the frequency of outpatient colorectal cancer screening among trainees, specialists or consultants (p=0.628), there was a clear increase in the reported referrals as the training years or the years of experience increases (p=0.049 for trainees and p=0.009 for faculty). Unclear pathway was reported as the main obstacle to outpatient cancer screening by 30.2% (n= 48) and 54% (n=87) pointed out that an easy and clear pathway for cancer screening would facilitate the same. Conclusion: While the attitude towards colorectal cancer screening is positive, the actual practice of recommendation is sub-optimal. Further initiatives are required to facilitate awareness and compliance to colorectal cancer screening.

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“…More than 1.8 million new CRC cases and 881,000 deaths was reported in 2018, accounting for about 1 in 10 cases and deaths [1]. Regardless of, the low incidence of CRC in the Middle East [2], the Kurdistan region of Iraq has a higher annual incidence rate of cancer, and it represents about 38 to 61.7 cases/100,000 population and it’s the fourth cancer in both sexes separately, and the cause of mortality of about 8.6% [3]. The most common histopathological type of CRC in this region is adenocarcinoma [4].…”

Section: Introductionmentioning

confidence: 99%

The vasodilatory mechanism of nitric oxide and hydrogen sulfide in human mesenteric artery of colorectal cancer patients: role of potassium channels

Hassan

Maulood

Salihi

2019

Preprint

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26Recent studies focused on the role of gasotransmitters in cancer 27 progression and prevention. Therefore, this study was designed to explore 28 the vasodilator activity of NO and H 2 S in human mesenteric artery of CRC 29 patients via activation of K + channels. For this purpose, two sets of 30 experiments were established. The blood samples from CRC patients were 31 obtained to detect serum levels of Endocan and MDA. Moreover, the role of 32 K + channels were assessed in mediating vasodilation of human mesenteric 33 artery in response to SNP and Na 2 S. The level of serum Endocan was 34 decreased in CRC patients compared to healthy individuals, while serum 35 MDA was not changed. The arterial rings precontracted with NE were first 36 relaxed by cumulative addition of increasing concentrations of either SNP 37 (30nM-30μM) or Na 2 S (1-6mM). Then maximal relaxation rates were 38 calculated for four times at each 15min intervals. Preincubation of arterial 39 rings for 20min with individual K + channels blockers were significantly 40 reduced relaxation caused by SNP and Na 2 S at different time intervals. 41 Furthermore, pretreatment of L-NAME did not change the vasodilation 42 induced by Na 2 S. Vasodilation of CRC mesenteric unchanged by synergistic 43 application of SNP and Na 2 S. While preincubation of arterial rings with PAG 44 significantly enhanced vasodilation induced by SNP. In conclusion, these 45 results indicate that endothelial dysfunction and oxidative stress do not take 46 part in the pathogenesis of CRC. The dilatory mechanisms of NO and H 2 S 47 3 48 and the activity of CSE enzyme slows down the vasodilator ability of 49 exogenous NO. 50 Introduction 53 Colorectal cancer (CRC) is the third most frequently occurring 54 malignancy and the second leading mortality cause of cancer worldwide. 55 More than 1.8 million new CRC cases and 881,000 deaths was reported in 56 2018, accounting for about 1 in 10 cases and deaths [1]. Regardless of, the 57 low incidence of CRC in the Middle East [2], the Kurdistan region of Iraq 58 has a higher annual incidence rate of cancer, and it represents about 38 to 59 61.7 cases/100,000 population and it's the fourth cancer in both sexes 60 separately, and the cause of mortality of about 8.6% [3]. The most common 61 histopathological type of CRC in this region is adenocarcinoma [4]. 62 Endogenous gasotransmitters mainly nitric oxide (NO), carbon 63 monoxide (CO), and hydrogen sulfide (H 2 S) are generated endogenously by 64 specific enzymes [5]. NO is produced from L-arginine by the enzyme NO 65 synthase (NOS) [6, 7] while H 2 S is synthesised from L-cysteine by either 66 cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) or 67 mercaptopyruvate sulfurtransferase (MST) [8, 9]. They can modulate 68 different biological pathways and functions at a physiologically relevant 69 concentration [10] by the opening of various kinds of membrane ion 4 70 channels [11]. NO is an essential regulator of angiogenesis [12] and 71 vasorelaxation through activation of gua...

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A Review of the Incidence of Colorectal Cancer in the Middle East

Cited by 10 publications

References 22 publications

Associations with the Receipt of Colon Cancer Screening Among a Diverse Sample of Arab Americans in NYC

Associations with the Receipt of Colon Cancer Screening Among a Diverse Sample of Arab Americans in NYC

<p>Knowledge, Attitude and Practice of Physicians Regarding Screening of Colorectal Cancer in Qatar: A Cross-Sectional Survey</p>

The vasodilatory mechanism of nitric oxide and hydrogen sulfide in human mesenteric artery of colorectal cancer patients: role of potassium channels

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