A Review of the Epidemiology, Pathogenesis and Management of Tetanus

Mallick, I.; Winslet, MC

doi:10.1016/s1743-9191(06)60056-3

Cited by 26 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it might be possible to extend the current period of 10 years between consecutive booster doses as recommended in our country. This was also described by Mallick et al 2. On the other hand, the sporadic cases of tetanus that still occur in the Netherlands (0–5 per year for 1997–2014) show that tetanus prophylaxis does not reach all individuals who require this 3…”

Section: Introductionsupporting

confidence: 61%

See 1 more Smart Citation

Performance of a bedside test for tetanus immunity: results of a cross-sectional study among three EDs in the Netherlands in 2012–2013

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Introductionsupporting

confidence: 61%

“…Tetanus is a serious disease, acquired when spores of the bacterium Clostridium tetani infect a wound or a newborn's umbilical stump 1 2. Anaerobic conditions in the wound can lead to the production of the neurotoxin tetanospasmin, which causes muscle contractions and spasms.…”

Section: Introductionmentioning

confidence: 99%

Performance of a bedside test for tetanus immunity: results of a cross-sectional study among three EDs in the Netherlands in 2012–2013

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Spores of the tetanus bacillus, which are present in the soil and in the faeces of domestic animals, can enter the body through a wound. Anaerobic conditions can then lead to production of the neurotoxin tetanospasmin, which causes muscle contractions and spasms [2,3]. …”

Section: Introductionmentioning

confidence: 99%

The use of tetanus post-exposure prophylaxis guidelines by general practitioners and emergency departments in the Netherlands: a cross-sectional questionnaire study

et al. 2014

View full text Add to dashboard Cite

BackgroundThe Dutch National Immunisation Programme includes six tetanus toxoid (TT) vaccinations and reaches a high rate of vaccination coverage. In the Netherlands, several guidelines related to tetanus post-exposure prophylaxis (T-PEP) are in place. In 2003, the Dutch Health Council (HC) reviewed the use of T-PEP. The aim of this study is to evaluate whether the HC recommendations have been implemented.MethodsWe asked 178 Dutch General Practitioner (GP) offices and 60 Emergency Departments (EDs) to participate in a cross-sectional questionnaire study and requested that participating facilities send in the T-PEP guidelines adopted by their practice. The differences, based on categories mentioned in the HC recommendations, between GPs and EDs and the type of T-PEP guidelines adopted were assessed.ResultsThe response rates for the GPs and EDs were 38% (n = 67) and 70% (n = 42), respectively. 98% percent (n = 107) of the participants reported having T-PEP guidelines. Of the guidelines described in the survey responses, 28% (n = 23; EDs 41%, GPs 21%) were consistent with the HC-recommendations, 36% (n = 29; EDs 7%, GPs 52%) adhered to the guidelines of the College of GPs (CGP), which restricts the use of T-PEP to tetanus prone wounds but for these wounds is in line with the recommendations of the HC. The remaining 36% had adopted other guidelines, most of which can lead to over-prescription of T-PEP. Information on T-PEP was lacking in patients with higher risk vaccination histories.ConclusionAlmost all participants have adopted T-PEP guidelines. Strict adherence to the HC recommendations is low. More than half of GPs have adopted the more restrictive CGP-guideline, which limits T-PEP to tetanus prone wounds.

show abstract

“…This abnormalities are associated with an impairment of neural transmission caused by tetanospasmin and are a well-known complication of any injury with the possibility of progressing to necrosis. The incidence of tetanus in patients with wounds is unknown; however, recently concern has been raised over the proportion of tetanus cases in which a chronic wound is the portal of entry for Clostridium tetani, as occurred in our second patient (Cook et al, 2001;Mallick and Winslet, 2004).…”

Section: Discussionmentioning

confidence: 84%