A review of the efforts to develop muscle and musculoskeletal models for biomechanics in the last 50 years

Wakeling, James M.; Febrer-Nafría, Míriam; Groote, Friedl De

doi:10.1016/j.jbiomech.2023.111657

Cited by 17 publications

(9 citation statements)

References 132 publications

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“…However, the Hill model falls short of elucidating the underlying biological mechanisms of force generation in muscles [89][90][91]. Another shortcoming of this model is that it fails to consider variations in the contractile characteristics of various fibre types within muscles and the dependence of muscle tension on the movement history [89,91]. Modifications aimed at enhancing the accuracy of the Hill-type model predictions are reviewed in [91].…”

Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

“…The Hill model has enabled researchers to explore the mechanics of muscles using only a few rheological parameters. However, the Hill model falls short of elucidating the underlying biological mechanisms of force generation in muscles [89][90][91]. Another shortcoming of this model is that it fails to consider variations in the contractile characteristics of various fibre types within muscles and the dependence of muscle tension on the movement history [89,91].…”

Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

“…Another shortcoming of this model is that it fails to consider variations in the contractile characteristics of various fibre types within muscles and the dependence of muscle tension on the movement history [89,91]. Modifications aimed at enhancing the accuracy of the Hill-type model predictions are reviewed in [91]. This model is extremely versatile and not only can it be used to describe the behaviour of various types of muscles, but also it can be adapted and employed to describe force generation in non-muscle cells and their response to the physical and mechanical properties of their microenvironment [92][93][94].…”

Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

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Active viscoelastic models for cell and tissue mechanics

Tajvidi Safa,

Huang,

Kabla

et al. 2024

R. Soc. Open Sci.

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Living cells are out of equilibrium active materials. Cell-generated forces are transmitted across the cytoskeleton network and to the extracellular environment. These active force interactions shape cellular mechanical behaviour, trigger mechano-sensing, regulate cell adaptation to the microenvironment and can affect disease outcomes. In recent years, the mechanobiology community has witnessed the emergence of many experimental and theoretical approaches to study cells as mechanically active materials. In this review, we highlight recent advancements in incorporating active characteristics of cellular behaviour at different length scales into classic viscoelastic models by either adding an active tension-generating element or adjusting the resting length of an elastic element in the model. Summarizing the two groups of approaches, we will review the formulation and application of these models to understand cellular adaptation mechanisms in response to various types of mechanical stimuli, such as the effect of extracellular matrix properties and external loadings or deformations.

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Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

Section: Muscle Contraction Defined By the Hill Modelmentioning

confidence: 99%

See 1 more Smart Citation

Active viscoelastic models for cell and tissue mechanics

Tajvidi Safa,

Huang,

Kabla

et al. 2024

R. Soc. Open Sci.

View full text Add to dashboard Cite

show abstract

“…However, these experiments typically focus on measuring specific effects in isolation and do not always capture the interactions between different mechanisms that occur simultaneously. In this context, the biomechanical modelling of cell contraction potentially provides a theoretical framework for integrating experimental measurements into a unified picture [ 4 , 88 ].…”

Section: Active Cell Mechanicsmentioning

confidence: 99%

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Rodero,

Baptiste,

Barrows

et al. 2023

Front. Phys.

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Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link microscale physiology to whole-organ function. However, cardiac biomechanics models still have limited clinical translation. In this review, we provide a picture of cardiac mechanics models, focusing on their clinical translation. We review the main experimental and clinical data used in cardiac models, as well as the steps followed in the literature to generate anatomical meshes ready for simulations. We describe the main models in active and passive mechanics and the different lumped parameter models to represent the circulatory system. Lastly, we provide a summary of the state-of-the-art in terms of ventricular, atrial, and four-chamber cardiac biomechanics models. We discuss the steps that may facilitate clinical translation of the biomechanics models we describe. A well-established software to simulate cardiac biomechanics is lacking, with all available platforms involving different levels of documentation, learning curves, accessibility, and cost. Furthermore, there is no regulatory framework that clearly outlines the verification and validation requirements a model has to satisfy in order to be reliably used in applications. Finally, better integration with increasingly rich clinical and/or experimental datasets as well as machine learning techniques to reduce computational costs might increase model reliability at feasible resources. Cardiac biomechanics models provide excellent opportunities to be integrated into clinical workflows, but more refinement and careful validation against clinical data are needed to improve their credibility. In addition, in each context of use, model complexity must be balanced with the associated high computational cost of running these models.

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“…In this study, we explain the adjustment of MTC stiffness, using an approach based on the classical MTC model comprising a contractile component (CC) and series elastic component (SEC) connected in series (Hill, 1938; Wakeling et al, 2023). Assuming that both the CC and SEC function as linear springs, the overall MTC stiffness ( k MTC ) can be expressed as where k CC and k SEC represents the CC and SEC stiffnesses, respectively.…”

Section: Introductionmentioning

confidence: 99%

Leg stiffness adjustment during hopping by dynamic interaction between the muscle and tendon of the triceps surae

Kuriyama,

Takeshita

2024

Preprint

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The biomechanics underlying bouncing exercises are characterized by the spring-like behavior of the human leg. However, the mechanism underlying the mechanistic contribution of muscle dynamics to the adjustment of leg stiffness is unclear. This study aimed to elucidate the mechanisms governing the changes in leg stiffness during hopping at different frequencies by examining the dynamics of the muscle–tendon complex (MTC) of the medial gastrocnemius muscle (MG). We hypothesized that an increase in muscle stiffness would augment leg stiffness, thereby enabling hopping at higher frequencies. Kinematic and kinetic data were obtained using a motion capture system and force plates. Simultaneously, ultrasound images of the MG were acquired to quantify the muscle fascicle length and pennation angle. The results showed that the stiffness of the MTC increased with hop frequency and exhibited a strong correlation with the leg stiffness. In addition, with increasing frequency, the fascicle contractions shifted from isometric to concentric. To explain these results, an MTC model comprising a contractile component (CC) and series elastic component (SEC) was constructed. We observed a negative CC stiffness, which increased the MTC stiffness. Although this result appears to diverge from our initial hypothesis, the effect of negative CC stiffness on MTC stiffness can be understood, from the perspective of two springs in series, as an extension of the very high stiffness effect. This quantitative understanding of the dynamic interaction between the muscle and tendon offers a unified framework for interpreting various results of previous studies on fascicle dynamics during hopping.

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A review of the efforts to develop muscle and musculoskeletal models for biomechanics in the last 50 years

Cited by 17 publications

References 132 publications

Active viscoelastic models for cell and tissue mechanics

Active viscoelastic models for cell and tissue mechanics

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Leg stiffness adjustment during hopping by dynamic interaction between the muscle and tendon of the triceps surae

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