A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations

Gyles, Desireé Alesa; Castro, Lorena Diniz; Silva, José Otávio Carrera; Ribeiro-Costa, Roseane Maria

doi:10.1016/j.eurpolymj.2017.01.027

Cited by 383 publications

(228 citation statements)

References 125 publications

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“…On the one hand, the polysaccharides improve the biocompatibility of gels . On the other hand, we showed that the inclusion of small amounts of polysaccharides into the polymer network of PAAm gels significantly affects the Young's modulus and the electrical potential of synthetic gels.…”

Section: Discussionmentioning

confidence: 84%

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Biomimetic gels with chemical and physical interpenetrating networks

Dobreikina

Shklyar

Сафронов

et al. 2018

Polymer International

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This study aimed to create and to characterize the functional properties of gels with semi-interpenetrating network (semi-IPN) with focus on possible use of these composites in biomedical engineering. Polyacrylamide as a synthetic biocompatible polymer was chosen for the chemical network. The physical network comprised the gel-forming polysaccharides xanthan gum or gellan gum. Gels were synthesized by radical polymerization of acrylamide in aqueous solutions of polysaccharides. Mechanical and electrical properties of gels with 0.2, 0.4, 0.6, 0.8 and 1.0 wt% content of polysaccharide were investigated. It was found that the inclusion of a small amount of xanthan or gellan into the polymeric network of a polyacrylamide gel significantly shifts the gel electrical potential towards the rest potential of living cells and Young's modulus towards the elasticity limits of biological soft tissues like non-activated muscles. From the viewpoint of biomedical applications, the main advantage of the proposed composites is that the semi-IPN structure provides a nonlinear dependence of gel tension on gel deformation, which mimics the elasticity of natural tissues. This feature opens the possibility for the promising use of the proposed gels for musculoskeletal minibioimplants or scaffolds for tissue engineering.

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Section: Discussionmentioning

confidence: 84%

“…To improve the biocompatibility of synthetic hydrogels, biomacromolecules such as collagen, fibrin, fibronectin or various polysaccharides can be introduced as the fillers of gel networks …”

Section: Introductionmentioning

confidence: 99%

Biomimetic gels with chemical and physical interpenetrating networks

Dobreikina

Shklyar

Сафронов

et al. 2018

Polymer International

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“…It should neither irritate nor sensitize the oral mucosa. Moreover, it should be of such a consistency that spreads easily when stress force is applied and should also remain in the application site for a long time [36]. In gel formulations, various polymeric materials are used to obtain a viscous gel with a network structure.…”

Section: Preparation and Physicochemical Characteristics Of Hydrogelsmentioning

confidence: 99%

Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral Mucosa

et al. 2020

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Periodontal diseases are some of the most widespread oral afflictions, and they are labeled as chronic infections caused by the accumulation of bacteria in dental plaque that produces localized inflammation of the periodontium. The use of local drug delivery systems to treat periodontal diseases has received greater attention, because the active substance is targeted directly to the affected area, which minimizes its systemic side effects. Therefore, the purpose of the investigation was to develop and characterize different types of gel formulations-bigel, hydrogel and oleogel-as local delivery systems containing metronidazole (MET), which can be applied to the oral mucosa. The influence of the formulation type on the mechanical, rheological and mucoadhesive properties were examined. Moreover, in vitro release of metronidazole, its ex vivo permeation through buccal porcine mucosa and antimicrobial activity measured by the plate diffusion method were estimated. It was found that the gel formulations obtained were non-Newtonian systems, showing a shear-thinning behavior and thixotropic properties with good textural features such as firmness, compressibility and adhesiveness. Moreover, the preparations designed possessed beneficial mucoadhesive properties. The formulated hydrogels and bigels containing micronized MET were considered as better formulations in terms of drug release and antimicrobial activity compared to commercially available metronidazole ointment. An ex vivo permeation study with the use of porcine buccal mucosa demonstrated that the bigel formulation was characterized by higher initial permeability rate providing a fast therapeutic effect with simultaneous moderate retention in mucosal tissue to decrease the risk of local cytotoxicity.

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“…Hydrogels prepared from methacrylate monomers have been used as biomaterials in a wide range of applications . In particular, poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels of several molar masses, in the range 1000–8000 g mol −1 , have been prepared and characterized by Lin‐Gibson et al .…”

Section: Resultsmentioning

confidence: 99%

“…The interest in new formulations of hydrogels is revealed by the considerable number of both papers and patents published by academic research institutions and industrial organizations every year . Although many natural polymers are used to produce hydrogels, the versatility offered by synthetic polymers has increased markedly their practical utility . Mono‐ and multifunctional (meth)acrylate monomers and their derivatives have been widely used for the synthesis of hydrogels .…”

Section: Introductionmentioning

confidence: 99%

Novel hydrogels based on a high‐molar‐mass water‐soluble dimethacrylate monomer

Asmussen

Gómez

Vallo

2018

Polymer International

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This report describes the preparation and swelling behaviour of novel hydrogels based on a water‐soluble dimethacrylate monomer (EBisEMA), which is characterized by a relatively high molar mass (Mn ∼ 1700 g mol−1) and contains a high proportion of aliphatic ether bonds in its structure. This feature results in moderately crosslinked and flexible polymer networks. Significant differences were observed in degree of swelling, depending on the synthesis method employed to obtain the hydrogels. The equilibrium water sorption of EBisEMA photopolymerized in bulk was 68 wt% while that of EBisEMA photopolymerized in aqueous solution (0.5 g mL−1) was 104 wt%. Thiol–methacrylate hydrogels were prepared by visible light photopolymerization of EBisEMA with a tetrafunctional thiol (PETMP) at various EBisEMA‐to‐PETMP molar ratios. These hydrogels contained unreacted thiol groups because of a faster homopolymerization reaction of EBisEMA. Hydrogels were also prepared in bulk by propylamine‐catalysed Michael addition reaction. No significant differences in swelling were observed between EBisEMA homopolymer and photocured EBisEMA–PETMP copolymer. Conversely, a marked increase in water uptake (110 wt%) was observed in the EBisEMA–PETMP hydrogels prepared by the Michael addition reaction catalysed by propylamine. These trends are explained in terms of a balance between the mass fraction of hydrophilic groups and the crosslinking density of the network. EBisEMA–PETMP hydrogels formulated with thiol in excess showed a noticeable tendency to adhere to diverse substrates, including paper, metals, glass and skin. This feature makes them especially attractive in applications for which adhesion is particularly critical such as dermatological patches. © 2018 Society of Chemical Industry

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A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations

Cited by 383 publications

References 125 publications

Biomimetic gels with chemical and physical interpenetrating networks

Biomimetic gels with chemical and physical interpenetrating networks

Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral Mucosa

Novel hydrogels based on a high‐molar‐mass water‐soluble dimethacrylate monomer

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