A review of the current understanding of nanoparticles protein corona composition

Breznica, Pranvera; Koliqi, Rozafa; Daka, Aferdita

doi:10.15386/mpr-1756

Cited by 22 publications

(29 citation statements)

References 79 publications

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“…In this study, we have demonstrated that DND is a potent pan-cytokine adsorber. It is well known that nanoparticles effectively bind proteins to form protein coronae with some specificity exist due to their unique physicochemical properties such as size, surface charge, and hydrophobicity ( Breznica et al, 2020 ). As the size of nanoparticles decreases, the protein binding affinity increases because smaller particles have a higher surface area and a higher surface reactivity compared to their larger counterparts ( Cedervall et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Nanodiamond as a Cytokine Sponge in Infectious Diseases

Yoo

Lee

Kim

et al. 2022

Front. Bioeng. Biotechnol.

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Cytokine release syndrome (CRS) is a systemic inflammatory response resulting in overexpression of cytokines in serum and tissues, which leads to multiple-organ failure. Due to rapid aggravation of symptoms, timely intervention is paramount; however, current therapies are limited in their capacity to address CRS. Here, we find that the intravenous injection of highly purified detonation-synthesized nanodiamonds (DND) can act as a therapeutic agent for treating CRS by adsorbing inflammatory cytokines. Highly purified DNDs successfully inactivated various key cytokines in plasma from CRS patients with pneumonia, septic shock, and coronavirus disease 2019 pandemic (COVID-19). The intravenous injection of the DND samples in a mouse sepsis model by cecal ligation and puncture significantly improved survival rates and prevented tissue damage by reducing the circulating inflammatory cytokines. The results of this study suggest that the clinical application of highly purified DND can provide survival benefits for CRS patients by adsorbing inflammatory cytokines.

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Section: Discussionmentioning

confidence: 99%

Nanodiamond as a Cytokine Sponge in Infectious Diseases

Yoo

Lee

Kim

et al. 2022

Front. Bioeng. Biotechnol.

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“…Many different nanomaterials have been reported to strongly interact with biological fluids and form a bio-corona, (Galmarini et al, 2018;Mandal et al, 2018;Tenzer et al, 2013;Yu et al, 2020), and this property has led to important applications, for example, as an analytical tool for the detection of different diseases (Giulimondi et al, 2019), such as cancer (Di Domenico et al, 2018). However, the formation of bio-corona is not always a desirable property: for example, it was shown that NPs without PC has higher targeting efficiency (Feiner-Gracia et al, 2017;Md Rasib et al, 2019) and cellular uptake (Breznica et al, 2020;Ghazaryan et al, 2019;Giulimondi et al, 2019.;Tonigold et al, 2018). The study of biomolecular corona, in the context of drug delivery, has been used by researchers mainly to tailor the properties of NPs for three main objectives, schematically shown in Figure 1: (i) to introduce "stealth" characteristics, (ii) to have efficient targeting, and (iii) to obtain low fouling materials.…”

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confidence: 99%

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

Bilardo

Traldi

Vdovchenko

et al. 2022

WIREs Nanomed Nanobiotechnol

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Nanomaterials offer promising solutions as drug delivery systems and imaging agents in response to the demand for better therapeutics and diagnostics. However, the limited understanding of the interaction between nanoparticles and biological entities is currently hampering the development of new systems and their applications in clinical settings. Proteins and lipids in biological fluids are known to complex with nanoparticles to form a "biomolecular corona". This has been shown to affect particles' morphology and behavior in biological systems and their interactions with cells. Hence, understanding how nanomaterials' physicochemical properties affect the formation and composition of this biocorona is a crucial step. This work evaluates existing literature on how morphology (size and shape), and surface chemistry (charge and hydrophobicity) of nanoparticles influence the formation of protein corona. The latest evidence suggest that although surface charge promotes the interaction with proteins and lipids, surface chemistry plays a leading role in determining the affinity of the nanoparticle for biomolecules and, ultimately, the composition of the corona. More recently the study of additional nanoparticles' properties like shape and surface chirality have demonstrated a significant effect on protein corona architecture, providing new tools to tailor biomolecular corona formation.

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“…An emerging strategy for targeting NPs to tumors is modifying the nanoparticle surface to promote interactions with biological components that naturally target specific cells. In the presence of fluids like blood or cell culture media, NPs adsorb biomolecules forming what has been termed a “corona” . This corona is composed of proteins and possibly other biological molecules like lipids.…”

Section: Introductionmentioning

confidence: 99%

“…In the presence of fluids like blood or cell culture media, NPs adsorb biomolecules forming what has been termed a "corona". 9 This corona is composed of proteins and possibly other biological molecules like lipids. A protein corona is likely formed by two distinct layers: a hard corona made from proteins with a strong affinity for the nanoparticle surface and a soft corona consisting of proteins that may transiently interact with NPs.…”

Section: ■ Introductionmentioning

confidence: 99%

Polymeric Nanoparticles with a Sera-Derived Coating for Efficient Cancer Cell Uptake and Killing

et al. 2021

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Nanoparticle-mediated cancer drug delivery remains an inefficient process. The protein corona formed on nanoparticles (NPs) controls their biological identity and, if optimized, could enhance cancer cell uptake. In this study, a hyperbranched polyester polymer (HBPE) was synthesized from diethyl malonate and used to generate NPs that were subsequently coated with normal sera (NS) collected from mice. Cellular uptake of NStreated HBPE-NPs was compared to PEGylated HBPE-NPs and was assessed using MDA-MB-231 triple-negative breast cancer (TNBC) cells as well as endothelial and monocytic cell lines. NStreated HBPE-NPs were taken up by TNBC cells more efficiently than PEGylated HBPE-NPs, while evasion of monocyte uptake was comparable. NS coatings facilitated cancer cell uptake of HBPE-NPs, even after prior interaction of the particles with an endothelial layer. NS-treated HBPE-NPs were not inherently toxic, did not induce the migration of endothelial cells that could lead to angiogenesis, and could efficiently deliver cytotoxic doses of paclitaxel (taxol) to TNBC cells. These findings suggest that HBPE-NPs may adsorb select sera proteins that improve uptake by cancer cells, and such NPs could be used to advance the discovery of novel factors that improve the bioavailability and tissue distribution of drugloaded polymeric NPs.

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A review of the current understanding of nanoparticles protein corona composition

Cited by 22 publications

References 79 publications

Nanodiamond as a Cytokine Sponge in Infectious Diseases

Nanodiamond as a Cytokine Sponge in Infectious Diseases

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

Polymeric Nanoparticles with a Sera-Derived Coating for Efficient Cancer Cell Uptake and Killing

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