“…Fish and Waterman (1972) analysed the alkaloids of seven African species Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 19721973 Fish andWaterman, 1972;1973Phillips and Castle, 1981Fish and Waterman, 1973Fish and Waterman, 1973Fournet, 1978Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 19721973;Phillips andCastle, 1981 Fish andWaterman, 1972;1973;Schnell, 1957;Walker and Sillans, 1961Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 1973Fish and Waterman, 19721973;Phillips and Castle, 1981;Waterman, 1986Fish and Waterman, 1973Fish and Waterman, 1973Phillips and Castle,l981 Fish and Waterman, 1972;1973 It would seem that a peak in the level of alkaloids of the 1-benzyltetrahydroisoquinoline category is reached in the Rutaceae to then be replaced by more 'modern' metabolites such as anthranilic acid derivatives and coumarins; under these conditions, Zunthoxylum and Fugaru could then be considered as primitive genera within the Rutaceae.…”