A review of the botany, traditional uses, phytochemistry and pharmacology of Stemonae Radix

Wang, Lixia; Wu, Hongwei; Li, Cong; Jiang, Tong; Yang, Xiaoguang; Xiao-xu, Chen; Tang, Liying; Wang, Zhuju

doi:10.1007/s11101-021-09765-1

Cited by 7 publications

(3 citation statements)

References 72 publications

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“…Toxicity of Stemona alkaloids is an issue often occurring in feeding assays against larvae. ,, These alkaloids can be divided into stichoneurine-, croomine-, and protostemonine-type alkaloids as a result of their core structures. , Derivatives belonging to the last group showed in many assays pronounced toxicities against larvae of the polyphagous Spodoptera species, especially stemofoline and its derivative 1, 2-didehydrostemofoline, whose cage structure built up by C–C and oxygen bridge between pyrrol and the azepine rings is pivotal to their activities as agonist or antagonist at insect nicotinic acetylcholine receptors. ,, The 16 alkaloids that we obtained all belong to the protostemonine type, and the newly described compound 12 possesses the stemofoline cage structure and exhibited some deterring effects against the snails. However, these alkaloids did not lead to a lethal effect as their homologues did to larvae.…”

Section: Discussionmentioning

confidence: 99%

Search for Snail Repellents: Antimollusc Activities from Stemona parviflora and Six Other Chinese Stemona Species

Teng,

Tan,

et al. 2024

J. Agric. Food Chem.

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Snails are important agricultural pests difficult to control, but data regarding molluscicidal assays are scant. Stemona alkaloids are typical secondary metabolites for the taxa and have been broadly investigated for their pharmacological and toxicological effects. This makes it possible for us to further develop the toxicities of these compounds to snails. In this work, we tested the antifeedant properties of leaves from seven Chinese Stemona species against the land snail species Bradybaena ravida in choice and non-choice feeding assays. The tested leaves Stemona parviflora exhibited the most deterrent effects, and a further phytochemical investigation of aerial parts led to the identification of 16 alkaloids. Among them, three novel alkaloids could be identified. The alkaloidal fraction and single alkaloids were further assayed against this snail species, and the results suggest a cocktail effect because the impact of the alkaloidal fraction was higher than the effects caused by single alkaloids. The study can promote the search process of natural antimollusc products from plants to control snails.

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Section: Discussionmentioning

confidence: 99%

Search for Snail Repellents: Antimollusc Activities from Stemona parviflora and Six Other Chinese Stemona Species

Teng,

Tan,

et al. 2024

J. Agric. Food Chem.

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“…Stemona tuberosa Lour is a medicinal plant found in the southern area of the Yangtze River Basin in China. It has been used to treat eczema, scabies, pertussis, and other illnesses [ 1 ]. In East and Southeast Asia, extracts from Stemona tuberosa Lour are employed as household insecticides and as a treatment for respiratory ailments [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Structure and Bioactivity of Polysaccharides from Different Parts of Stemona tuberosa Lour

Qiu,

Ou,

et al. 2024

Molecules

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The polysaccharides from Stemona tuberosa Lour, a kind of plant used in Chinese herbal medicine, have various pharmacological activities, such as anti-inflammatory and antioxidant properties. However, the effects of the extraction methods and the activity of polysaccharides from different parts are still unknown. Therefore, this study aimed to evaluate the effects of different extraction methods on the yields, chemical compositions, and bioactivity of polysaccharides extracted from different parts of Stemona tuberosa Lour. Six polysaccharides were extracted from the leaves, roots, and stems of Stemona tuberosa Lour through the use of hot water (i.e., SPS-L1, SPS-R1, and SPS-S1) and an ultrasound-assisted method (i.e., SPS-L2, SPS-R2, and SPS-S2). The results showed that the physicochemical properties, structural properties, and biological activity of the polysaccharides varied with the extraction methods and parts. SPS-R1 and SPS-R2 had higher extraction yields and total sugar contents than those of the other SPSs (SPS-L1, SPS-L2, SPS-S1, and SPS-S2). SPS-L1 had favorable antioxidant activity and the ability to downregulate MUC5AC expression. An investigation of the anti-inflammatory properties showed that SPS-R1 and SPS-R2 had greater anti-inflammatory activities, while SPS-R2 demonstrated the strongest anti-inflammatory potential. The results of this study indicated that SPS-L1 and SPS-L2, which were extracted from non-medicinal parts, may serve as potent natural antioxidants, but further study is necessary to explore their potential applications in the treatment of diseases. The positive anti-inflammatory effects of SPS-R1 and SPS-R2 in the roots may be further exploited in drugs for the treatment of inflammation.

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“…We chose stemoamide (1, Fig. 1), isolated from Stemonaceae plants (12), as an ideal target molecule because its four stereocenters and fused-ring structure would challenge modern CASP (11), while its precedence in thirty-two historic and contemporary syntheses (13)(14)(15)(16)(17)(18)(19)(20)(21) provides a strong benchmark for comparison.…”

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confidence: 99%

Computer-aided key step generation in alkaloid total synthesis

Lin

Zhang

Wang

et al. 2023

Science

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Efficient chemical synthesis is critical to satisfying future demands for medicines, materials, and agrochemicals. Retrosynthetic analysis of modestly complex molecules has been automated over the course of decades, but the combinatorial explosion of route possibilities has challenged computer hardware and software until only recently. Here, we explore a computational strategy that merges computer-aided synthesis planning with molecular graph editing to minimize the number of synthetic steps required to produce alkaloids. Our study culminated in an enantioselective three-step synthesis of (–)-stemoamide by leveraging high-impact key steps, which could be identified in computer-generated retrosynthesis plans using graph edit distances.

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A review of the botany, traditional uses, phytochemistry and pharmacology of Stemonae Radix

Cited by 7 publications

References 72 publications

Search for Snail Repellents: Antimollusc Activities from Stemona parviflora and Six Other Chinese Stemona Species

Search for Snail Repellents: Antimollusc Activities from Stemona parviflora and Six Other Chinese Stemona Species

Study of the Structure and Bioactivity of Polysaccharides from Different Parts of Stemona tuberosa Lour

Computer-aided key step generation in alkaloid total synthesis

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