A review of the biological activities of lactoferrin: mechanisms and potential applications

Hong, Ruiyao; Xie, Aijun; Jiang, Chengxi; Guo, Yangze; Zhang, Yumeng; Chen, Jiali; Shen, Xinyu; Li, Mohan; Yue, Xiqing

doi:10.1039/d4fo02083a

Food Funct.

2024

DOI: 10.1039/d4fo02083a

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A review of the biological activities of lactoferrin: mechanisms and potential applications

Ruiyao Hong,

Aijun Xie,

Chengxi Jiang

et al.

Abstract: Lactoferrin, a multifunctional iron-binding protein found in milk and other body fluids, possesses numerous biological activities. The functional activity of lactoferrin lies not only in its iron-binding capacity, but also...

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The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review

Shen,

Ma,

Yang

et al. 2024

Foods

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With economic growth and improved living standards, the incidence of metabolic diseases such as diabetes mellitus caused by over-nutrition has risen sharply worldwide. Elevated blood glucose and complications in patients seriously affect the quality of life and increase the economic burden. There are limitations and side effects of current hypoglycemic drugs, while probiotics, which are safe, economical, and effective, have good application prospects in disease prevention and remodeling of intestinal microecological health and are gradually becoming a research hotspot for diabetes prevention and treatment, capable of lowering blood glucose and alleviating complications, among other things. Probiotic supplementation is a microbiologically based approach to the treatment of type 2 diabetes mellitus (T2DM), which can achieve anti-diabetic efficacy through the regulation of different tissues and metabolic pathways. In this study, we summarize recent findings that probiotic intake can achieve blood glucose regulation by modulating intestinal flora, decreasing chronic low-grade inflammation, modulating glucagon-like peptide-1 (GLP-1), decreasing oxidative stress, ameliorating insulin resistance, and increasing short-chain fatty acids (SCFAs) content. Moreover, the mechanism, application, development prospect, and challenges of probiotics regulating blood glucose were discussed to provide theoretical references and a guiding basis for the development of probiotic preparations and related functional foods regulating blood glucose.

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The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review

Shen,

Ma,

Yang

et al. 2024

Foods

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show abstract

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A review of the biological activities of lactoferrin: mechanisms and potential applications

Abstract: Lactoferrin, a multifunctional iron-binding protein found in milk and other body fluids, possesses numerous biological activities. The functional activity of lactoferrin lies not only in its iron-binding capacity, but also...

Cited by 1 publication

References 111 publications

The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review

The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review

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