A review of the applications of solid state physics concepts to biological systems

Cope, Freeman W.

doi:10.1007/bf02308900

Cited by 57 publications

(22 citation statements)

References 119 publications

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“…Non-homogeneity and disorder characterize the malignant growth observed by NMR measurements [62], [63], [64] and supported by theoretical considerations [65]. As a consequence of the bond-disorder in extra-cellular liquid, a high dielectric constant is to be expected at the applied frequency.…”

Section: Electro-hyperthermiamentioning

confidence: 99%

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Szász¹,

Szász²,

Szász³

2001

Deutsche Zeitschrift für Onkologie

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Hyperthermia is a rapidly developing treatment method in tumor-therapy. The classical effect is based on well-focused energy absorption targeting the malignant tissue. The treatment temperature has been considered as the main technical parameter. Unfortunately, the heat-shock protein (HSP) synthesis may considerably suppress the treatment's efficiency, adapting cells to survive the shock.Electro-hyperthermia heats up the targeted tissue by means of electricity, producing less HSP-synthesis in the cells than a usual hyperthermia process. The main idea is to keep the energy absorption in the extracellular liquid and, by heating it, increase the ion-mobility, intensify the metabolic rate of the cells, and destroy the cell membrane before the heat-shock activates the intra-cellular HSP mechanisms.

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Section: Electro-hyperthermiamentioning

confidence: 99%

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Szász¹,

Szász²,

Szász³

2001

Deutsche Zeitschrift für Onkologie

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“…(Hyman et al, 1995) but also provides a unifying explanation for the effects of temperature (Fygenson et al, 1994) and glycerol (Fygenson, 1995) on microtubule disassembly rates. The importance of the water microenvironment NMR evidence (Cope, 1975;Hazelwood et al, 1969;) strongly indicates that cell water possesses more structure than liquid water, and that much of the Na + and K + in the cell is not free in aqueous solution, but is associated with charged sites on macromolecules (Cope, 1975 (Cooke & Kuntz, 1974;Franks, 1975;Clegg, 1981). Of great interest is the fact that most of the vicinal water surrounds the cytoskeleton (Clegg, 1981).…”

Section: Magnetic Field In Axonsmentioning

confidence: 99%

Electric and Magnetic Fields Inside Neurons and Their Impact Upon the Cytoskeletal Microtubules

Georgiev

2003

SSRN Journal

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If we want to better understand how the microtubules can translate and input the information carried by the electrophysiologic impulses that enter the brain cortex, a detailed investigation of the local electromagnetic field structure is needed. In this paper are assessed the electric and the magnetic field strengths in different neuronal compartments. The calculated results are verified via experimental data comparison. It is shown that the magnetic field is too weak to input information to microtubules and no Hall effect, respectively QHE is realistic. Local magnetic flux density is less than 1 /300 of the Earth's magnetic field that's why any magnetic signal will be suffocated by the surrounding noise. In contrast the electric field carries biologically important information and acts upon voltage-gated transmembrane ion channels that control the neuronal action potential. If mind is linked to subneuronal processing of information in the brain microtubules then microtubule interaction with the local electric field, as input source of information is crucial. The intensity of the electric field is estimated to be 10V/m inside the neuronal cytoplasm however the details of the tubulin-electric field interaction are still unknown. A novel hypothesis stressing on the tubulin C-termini intraneuronal function is presented replacing the current flawed models (Tuszynski 2003, Mershin 2003, Porter 2003 The electric currents are relevant stimuli eliciting conscious experience like memorization of past events (Wilder Penfield, 1954a;1954b;1955) (2000) has helped a blind man to see again using electrodes implanted into his brain and connected to a tiny television camera mounted on a pair of glasses. Although he does not "see" in the conventional sense, he can make out the outlines of objects, large letters and numbers on a contrasting background, and can use the direct digital input to operate a computer. The man, identified only as Jerry, has been blind since age 36 after a blow to the head. Now 64, he volunteered for the study and got a brain implant in 1978. There has been no infection or rejection in the past 24 years. 7Scientists have been working since 1978 to develop and improve the software that enables Jerry to use the device as a primitive visual system. Jerry's "eye" consists of a tiny television camera and an ultrasonic distance sensor mounted on a pair of eyeglasses. Both devices communicate with a small computer, carried on his hip, which highlights the edges between light and dark areas in the camera image. It then tells an adjacent computer to send appropriate signals to an array of 68 small platinum electrodes on the surface of Jerry's brain, through wires entering his skull behind his right ear. The electrodes stimulate certain brain cells, making Jerry perceive dots of light, which are known as phosphenes.Jerry gets white phosphenes on a black background. With small numbers of phosphenes you have (the equivalent of) a time and temperature sign at a bank.As you get larger and larger numbers of phosphenes...

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“…The generalized solution of the bifurcative phenomena in living materials was worked out earlier, [77]. The ordered water was supposed to account for as much as 50% of the total amount of water in the living bodies [89], but the systematic investigations showed more of it [90,91].…”

Section: Transport Propertiesmentioning

confidence: 99%

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

Gp¹,

Szász²,

Hegyi³

2016

J Neoplasm

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Numerous theories and hypotheses are published about the causes of cancer and its hallmarks. Two remarkable principles were established and debated for a long time. The first is the Warburg-effect, which based on mitochondrial dysfunction, connected to the intensive metabolic activity of the malignancy. The other is the Szentgyorgyi's effect which describes the malignancy by changing of the cellular state (α ↔ β) explained by evolutional biology and supported by definitely improved dielectric properties of the malignant tissue from their normal counterpart while these theories have stable explanations, developed many controversies. Both are partial of completely revised time-by-time, showing new insights with new evidence as additions to these old ideas. Our objective is to demonstrate connections between these theories and start new considerations in the actual debates.

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A review of the applications of solid state physics concepts to biological systems

Cited by 57 publications

References 119 publications

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Electric and Magnetic Fields Inside Neurons and Their Impact Upon the Cytoskeletal Microtubules

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

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