A review of the anti‐inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes

Yaribeygi, Habib; Atkin, Stephen L.; Pirro, Matteo; Sahebkar, Amirhossein

doi:10.1002/jcp.27699

Cited by 56 publications

(59 citation statements)

References 117 publications

(173 reference statements)

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“…Two defined pathways that have been proposed to describe the evolution of diabetic kidney disease are hemodynamic and non-hemodynamic [ 9 ]. Although not fully understood, the role of hyperglycemia in pathophysiology of diabetic complications has been attributed to an increase in intra-glomerular pressure, elevation of single nephron glomerular filtration rate (GFR), and podocyte damage further perpetuating renal dysfunction [ 10 ]. Other contributory mechanisms include neurohumoral activation and cytokine release, along with proinflammatory pathway activation, potentiating tubulointerstitial inflammation and fibrosis [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

SGLT2 Inhibitors and Kidney Outcomes in Patients with Chronic Kidney Disease

Kanduri

Kovvuru

Hansrivijit

et al. 2020

JCM

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Globally, diabetes mellitus is a leading cause of kidney disease, with a critical percent of patients approaching end-stage kidney disease. In the current era, sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as phenomenal agents in halting the progression of kidney disease. Positive effects of SGLT2i are centered on multiple mechanisms, including glycosuric effects, tubule—glomerular feedback, antioxidant, anti-fibrotic, natriuretic, and reduction in cortical hypoxia, alteration in energy metabolism. Concurrently, multiple kidney and cardiovascular outcome studies have reported remarkable advantages of SGLT2i including mortality benefits. Additionally, the superiority of combination therapies (SGLT2I along with metformin/DDP-4 Inhibitors) in treatment-naïve diabetic patients is further looked into with potential signal towards glycemic and blood pressure control. Reported promising results initiate a gateway for future research targeting kidney outcomes with combination therapies as an initial approach. In the current paper, we summarize leading cardiovascular and kidney outcome trials in patients with type 2 diabetes, the role of SGLT2i in non-diabetic proteinuric kidney disease, and the potential mechanisms of action of SGLT2i with special focus on combination therapy as an initial therapeutic approach in treatment-naïve diabetic patients.

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Section: Introductionmentioning

confidence: 99%

SGLT2 Inhibitors and Kidney Outcomes in Patients with Chronic Kidney Disease

Kanduri

Kovvuru

Hansrivijit

et al. 2020

JCM

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“…64 In addition, new therapies/agents developed against DAMPs, PRRs, and PRR-associated downstream signaling molecules may effectively block the induction of diabetes. 64,67 In DVCs, the increased expression of cytokines/chemokines as well as the recruitment and activation of immune cells in the heart, kidney, and eye may be regulated by PRRs. The contribution of PRRs to inflammation in these vital organs has been widely studied (schematized in Figure 1).…”

mentioning

confidence: 99%

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

Wang

Antony

Wang

et al. 2020

Medicinal Research Reviews

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The innate immune system contains multiple classes of pattern recognition receptors (PRRs), which recognize pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) in the intracellular and extracellular space. Although PRRs are indispensable for the detection and clearance of invading pathogens, dysregulated PRR activation by extrinsic and intrinsic factors leads to inflammatory diseases. PRRmediated inflammation has been shown to play a pivotal role in the pathogenesis of diabetic vascular complications (DVCs), which are the leading causes of morbidity and mortality in diabetic patients. Upon sensing hyperglycemiagenerated DAMPs, PRRs activate intracellular signaling pathways leading to the production of proinflammatory cytokines and chemokines in various cells of the kidney, brain, eye, and heart. The resulting chronic, low-grade inflammation contributes to DVCs. In this review, we summarize the role of PRRs in DVCs including diabetic nephropathy, neuropathy, retinopathy, and cardiomyopathy. We propose that targeting PRRs and associated signaling pathways may be beneficial for the management of DVCs.

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“…Both black tea theaflavins and green tea catechins significantly attenuated high glucose-induced block of insulin signaling, reduced lipid accumulation, inhibited fatty acid synthesis, and stimulated fatty acid oxidation by activating the LKB1-AMPK pathway [54,102,103]. Furthermore, insulin deficiency and insulin resistance could induce exaggerated vasoconstriction [104], and black tea polyphenols could improve vasoconstriction through PI3K-Akt pathway and endothelial nitric oxide synthase (eNOS) phosphorylation [105,106].…”

Section: Experimental Studiesmentioning

confidence: 99%

“…In addition, white tea could regulate cardiac metabolic disorders by up-regulating the expression of cardiac GLUT1 and GLUT3 mRNA [87]. Quercetin, an important flavonoid found in write tea, could prevent diabetic vascular complications in both insulin deficiency and resistance by inhibiting inflammatory pathways, especially the NF-κB signaling [104].…”

Section: Experimental Studiesmentioning

confidence: 99%

Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review

et al. 2019

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Diabetes mellitus has become a serious and growing public health concern. It has high morbidity and mortality because of its complications, such as diabetic nephropathy, diabetic cardiovascular complication, diabetic neuropathy, diabetic retinopathy, and diabetic hepatopathy. Epidemiological studies revealed that the consumption of tea was inversely associated with the risk of diabetes mellitus and its complications. Experimental studies demonstrated that tea had protective effects against diabetes mellitus and its complications via several possible mechanisms, including enhancing insulin action, ameliorating insulin resistance, activating insulin signaling pathway, protecting islet β-cells, scavenging free radicals, and decreasing inflammation. Moreover, clinical trials also confirmed that tea intervention is effective in patients with diabetes mellitus and its complications. Therefore, in order to highlight the importance of tea in the prevention and management of diabetes mellitus and its complications, this article summarizes and discusses the effects of tea against diabetes mellitus and its complications based on the findings from epidemiological, experimental, and clinical studies, with the special attention paid to the mechanisms of action.

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A review of the anti‐inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes

Cited by 56 publications

References 117 publications

SGLT2 Inhibitors and Kidney Outcomes in Patients with Chronic Kidney Disease

SGLT2 Inhibitors and Kidney Outcomes in Patients with Chronic Kidney Disease

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review

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