A review of surgical methods (excluding hair transplantation) and their role in hair loss management today

Sattur, Sandeep

doi:10.4103/0974-2077.85020

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…The symptoms of hair loss and thinning start as bitemporal recession at the frontal hairline, followed by diffuse thinning over the vertex of the scalp [ 2 ]. The standard treatment for this condition is either hair follicle transplantation or the stimulation of these follicles with topical or oral medication [ 3 , 4 , 5 , 6 ]. However, these methods are not proven to treat hair loss and can have problematic side effects and high costs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.

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Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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“…The history of hair transplant can be traced as early as 1822 when Dieffenbach experimented with hair transplant in birds [1]. The field of surgical hair restoration thereafter progressed in two different directions where one group started exploring role of autografts while other segment of surgeons attempted various flaps and serial excisions, the former technique by far dominated and was adopted globally with time [2,3].…”

Section: Introductionmentioning

confidence: 99%

Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead

Sharma¹,

Ranjan²

2019

J. Maxillofac. Oral Surg.

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The hair transplant has become widely popular aesthetic procedure. Follicular unit transplantation (FUT) and follicular unit extraction (FUE) are two commonly used and accepted techniques. FUT requires excision of strip of tissue from occipital donor area leading to linear scar. To overcome scarring and other complications of FUT, FUE technique has been attempted which involves harvesting of small individual follicular units. Hair transplantation has been successfully used in correction of alopecia, cleft lip scars, post-burn or surgical scars, vitiligo and as an adjuvant to other maxillofacial procedures. FUE demands greater skills and orientation but can yield excellent results in experienced hands. Several maxillofacial surgeons have incorporated hair transplantation procedure in their aesthetic practice successfully. Sound knowledge of surgical technique, armamentarium and proper surgical planning are essential for desired results. The aim of this article is to explain FUE technique, risk and complications, holding solutions and other associated factors in detail. A simple protocol has been put forth for reference and for better understanding of the technique.

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“…Other rapidly developing techniques in hair restoration surgery have reduced the size of the donor area and smaller follicular units have replaced the larger cosmetically unacceptable punch grafting technique . Scalp reduction, with or without tissue expansion, scalp flaps, and other hair transplantation techniques have been continually revised over the last few years for the treatment of advanced androgenetic alopecia . Therefore, in the 21st century, men and women can envisage cosmetically more favorable and natural‐looking transplanted hair …”

Section: Methodsmentioning

confidence: 99%

“…Although it is neither life‐threatening nor does it lead to pain, evidence shows that it is an emotionally distressing and therapeutically frustrating disorder . Because of the psychological effects of androgenetic alopecia, active and definitive treatment is often sought by a few affected individuals, which has led to different hair restoration methods of which hair transplantation has superseded the rest of all methods so far . As a result, hair transplantation has become a popular option in some of the affected individuals as other cosmetic procedures in vogue today, such as face lift and rhinoplasty.…”

Section: Introductionmentioning

confidence: 99%

Hair restoration approaches for early onset male androgenetic alopecia

Bhatti¹,

Basra

Patel

2013

J of Cosmetic Dermatology

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Society places great emphasis on the presence of hair. Some degree of hair loss is accepted as a normal part of the aging process, in line with the observation that more than 50% of men will develop androgenetic alopecia by the age of 50 years. However, it is possible to understand the psychosocial isolation and distress felt by men with a strong familial predisposition to androgenetic alopecia, who tend to display hair loss in their late teens or twenties. There are currently two drugs which have been licensed for the treatment of male androgenetic alopecia: oral finasteride and topical minoxidil solution which are effective to some extent. Furthermore, upon discontinuing treatment, any gain that has been achieved is quickly lost. Added to which there is an entire market of unproven over the counter products: advertised in the electronic media, local hair salons, and various departmental stores. In this review, we highlight the important advances in the management of male androgenetic alopecia with emphasis on approaches that can lead to more successful and long-term hair restoration for young adults. In particular, we discuss the evidence supporting the use of the follicular unit grafting technique in conjunction with medical treatment before and after the procedure. Moreover, some other alterations of this most popular state of the art hair restoration technique have been mentioned briefly. As a result, patients and physicians seem equally satisfied from this procedure for its naturally looking results which are cosmetically more acceptable and esthetically pleasing for longer period of time.

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A review of surgical methods (excluding hair transplantation) and their role in hair loss management today

Cited by 10 publications

References 27 publications

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead

Hair restoration approaches for early onset male androgenetic alopecia

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