A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary

Abhilasha, N; Bafna, U. D.; Pallavi, V. R.; Rathod, Praveen S.; Krishnappa, Shobha

doi:10.4103/0019-509x.204763

Cited by 17 publications

(17 citation statements)

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“…Age-wise distribution of these cases is mentioned below in table no.1. Name of the study Year of publication Numbers of cases reported Age of occurrence Santwani PM et al [6] 2008 01 40 years Gupta V et al [10] 2009 02 30 years, 65 years Bashyal R et al [3] 2012 03 33 years, 51 years, 60 years Suna Avc1 et al [9] 2012 01 52 years Gupta N et al [4] 2014 01 65 years Ranu Patni [11] 2014 01 53 years Mardi K et al [12] 2014 01 68 years Yarmohammadi H et al [13] 2014 01 48 years Rekhi B et al [14] 2015 12 Median age = 49 years Sharma S et al [1] 2015 01 66 years Abhilasha N et al [8] 2016 10 Median age = 53.5 years Srivastava H et al [2] 2017 01 30 years Goudeli C et al [7] 2017 01 54 years ~ 323 ~ Indulkar ST et al [5] 2018 01 40 years Maharjan S [15] 2019 In our present study, painful enlargement or distension of abdomen is the presenting complaint of the patient herself. Similar complaints have been reported in other case studies also like those done by Bashyal R et al [3] , by Gupta N et al [4] , by Santwani PM et al [6] , etc.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma arising in an ovarian mature cystic teratoma: A case report

Menapara¹,

Kokani²

2019

Int. J. Clin. Diagn. Pathol.

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Pure primary squamous cell carcinoma (SCC) of the ovary is extremely rare. SCC can also arise in a mature cystic teratoma or dermoid cyst, in an ovarian endometrioma or in a brenner's tumor, but such malignant transformations are also quite rare. Development of SCC in a mature cystic teratoma (MCT) has been reported sporadically in less than 2% cases only. Here in our present study, we are reporting such a rare case of 65 years old postmenopausal woman who was diagnosed as having squamous cell carcinoma developed in a mature cystic teratoma of the ovary at our institute. This diagnosis was given on the basis of clinical (patient's history and examination), radiological (CT scan) and pathological (histopathology report) findings. We are also going to discuss other similar cases with review of literature. The only aim of this present study is to share our experience of such rare diagnosis with others.

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma arising in an ovarian mature cystic teratoma: A case report

Menapara¹,

Kokani²

2019

Int. J. Clin. Diagn. Pathol.

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“…Patients who received optimal cytoreduction followed with adjuvant chemotherapy seem to have a good outcome with longer survival. [8,9] Optimal cytoreduction can bring a mean survival of 14 months while 7.8 months in suboptimal cases. [10] Kikkawa et al [6] reported a 79% 5-year-survival rate for patients without residual disease compared with 10.1% for those with residual disease.…”

Section: Treatment Of Ovarian Sccmentioning

confidence: 99%

“…On account of the activity of cisplatin in ovarian cancer and gynaecological squamous-cell carcinomas, chemotherapy with cisplatin and taxane became a common therapy in SCC, and have been extended progression-free interval in most patients. [3,8,11,12] Patients received adjuvant chemotherapy (mostly platinum-based) appeared to survive longer than those who had surgery only. [4,13] Several studies suggested that chemotherapy with BEP can be used in ovarian SCC.…”

Section: Treatment Of Ovarian Sccmentioning

confidence: 99%

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Dong

Yuan

Yao

2020

Preprint

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Background: Malignant transformation such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT) is a rare tumor. The gene mutation of ovarian SCC remains unclear. We herein report a recurrent case of ovarian squamous cell carcinoma with MET gene copy number variation. Case presentation: A 60-year-old woman presented with recurrence of ovarian SCC 8 months after primary surgery. Adhesiolysis, right abdominal wall mass excision, prosthetics, enterectomy, enterostomy and partial cystectomy were performed by laparoscope. Pathologic examination demonstrated metastatic squamous cell carcinoma in ileocecus, rectum and abdominal wall muscle. MET gene copy number was elevated with copy number of six in this case. Postoperatively, the patient was treated with four cycles of combination chemotherapy with docetaxel and carboplatin. The patient was free of disease at 20 months’ follow-up. Conclusions: Optimal cytoreductive surgery combined with platinum-based chemotherapy is recommended currently for not only primary tumor but also recurrence. For patients with malignant transformation in OMCT, prompt diagnosis and individualized treatment are crucial for better prognosis. Increased copy number of MET may be correlated with her poor PFS and can be a potential therapeutic target for this case.

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“…Ovarian germ-cell tumors account for $ 20% of all ovarian neoplasms, and for 2% of all ovarian malignancies. [1][2][3] Mature cystic teratomas (MCTs) are the most common ovarian germcell tumors, accounting for $ 70% of benign ovarian tumors in women under 30 years of age, [4][5][6] and they are composed of totipotent cells developing into well-differentiated ectodermal, endodermal, and mesodermal tissue. 7 Ectodermal derivatives, which include keratinizing epidermis, sebaceous and sweat glands, hair follicles and neuroectodermal tissues, are often the most prominent.…”

Section: Introductionmentioning

confidence: 99%

Rare Case of Sarcomatoid Squamous Cell Carcinoma Arising in an Ovarian Mature Teratoma

Pedrosa

Alpendre

Sousa

et al. 2019

Rev Bras Ginecol Obstet

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Although mature cystic teratoma (MCT) is benign, malignant transformation (MT) occurs in ∼ 1% to 2% of all cases, and usually consists of squamous cell carcinoma (SCC), which accounts for ∼ 80% of the cases. Spindle-cell (sarcomatoid) carcinoma (SCSC) is an uncommon type of SCC, comprising up to 3% of all cases. The lack of characteristic symptoms and specific imaging findings may lead to preoperative misdiagnosis. Moreover, the clinicopathologic characteristics, the treatment, the prognostic factors and the mechanism of MT have not yet been well understood due to the rarity of such tumors, especially in women of reproductive age. The authors present a case of a 34-year-old patient with 14 weeks of gestation who was diagnosed with an adnexal mass suggestive of ovarian teratoma. A laparoscopy salpingo-oophorectomy was performed after 6 months of delivery, and the histological exam revealed a sarcomatoid SCC in the MCT.

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A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary

Cited by 17 publications

References 0 publications

Squamous cell carcinoma arising in an ovarian mature cystic teratoma: A case report

Squamous cell carcinoma arising in an ovarian mature cystic teratoma: A case report

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Rare Case of Sarcomatoid Squamous Cell Carcinoma Arising in an Ovarian Mature Teratoma

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