A review of spontaneous intracranial extradural hematoma in sickle-cell disease

Hettige, Samantha; Sofela, Agbolahan; Bassi, Sanj; Chandler, Chris

doi:10.1007/s00701-015-2582-6

Cited by 22 publications

(33 citation statements)

References 38 publications

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“…Although there are reports of spontaneous SGHs in the literature, to our knowledge none of them presented with isolated spontaneous SGHs as in this case. One case was similar to our case but with EDH on one side of the head and an SGH on the other side [10]. This finding was attributed to a skull infarction, which could also have been the reason for the hematoma in our case.…”

Section: Discussionsupporting

confidence: 84%

Spontaneous Subgaleal Hematoma in a Sickle Cell Disease Patient: A Case Report

2020

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Sickle cell disease (SCD) is one of the most commonly inherited conditions on the Arabian Peninsula. We report a case of a 17-yearold boy, who had previously been diagnosed with SCD and glucose-6-phosphate dehydrogenase (G6PD) deficiency and recently presented to our hospital with spontaneous subgaleal hematoma (SGH), which was managed conservatively. We also present a literature review on the topic of spontaneous intra-and/or extra-cranial bleeds.

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Section: Discussionsupporting

confidence: 84%

Spontaneous Subgaleal Hematoma in a Sickle Cell Disease Patient: A Case Report

2020

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“…There are 22 published case reports of EDHs in SCD. Hettige et al in 2015 published a thorough literature review that compares and contrasts the clinical and radiological findings in these 22 cases and briefly outlines the hypothesised mechanisms that underlie the formation of EDH in SCD 19. However, an in-depth summary of these mechanisms is lacking.…”

Section: Discussionmentioning

confidence: 99%

Acute spontaneous intracranial epidural haematoma and disseminated intravascular coagulation in a paediatric sickle cell patient

et al. 2018

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An African American teenage boy during an acute sickle cell crisis spontaneously developed acute bifrontal epidural haematomas (EDHs) in addition to disseminated intravascular coagulation (DIC). The successfully evacuated EDH reaccumulated postoperatively. After multiple transfusions, the patient underwent repeat surgery. Subsequent maximal medical therapy was unable to significantly improve the patient's neurological status, and due to family wishes, care was withdrawn. EDH are the most common emergent neurosurgical complication of sickle cell disease (SCD). Twenty-two such cases have been previously reported. We present one further complicated by DIC leading to reaccumulation of the patient's EDH. An understanding of the mechanisms of EDH formation in SCD and their associated radiological findings could help clinicians identify when a patient is at high risk of EDH formation and thus offer the potential for early intervention prior to the development of an emergency.

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“…However, a minority of patients may require urgent neurosurgical intervention if there are signs of raised or worsening intracranial pressure 4. Our case responded well to conservative management with intravenous fluids, oxygen and opioid analgesics, and repeat neuroimaging after 48 hours did not show any enhancement of the EDHs.…”

Section: Answer To Questionmentioning

confidence: 60%

Sickle cell crisis: A crisis of a different sort?

Kumar

Muwaijei

Sohal

2018

Arch Dis Child Educ Pract Ed

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A 9-year-old boy with sickle cell disease (SCD) was presented to the emergency department with acute headache and swelling over his bilateral temporoparietal region. There was no history of antecedent trauma, fever, vomiting or other features of an intercurrent illness. On arrival, his blood pressure was 112/62 mm Hg, heart rate was 98/min and his Glasgow Coma Scale score was 15/15. There was evidence of significant scalp tenderness over the bilateral temporoparietal region. A complete neurological examination including direct and consensual pupillary response was unremarkable. Initial investigations revealed haemoglobin of 9.6 g/dL, leucocyte count of 6.8/mm, platelet count of 219/mm and a normal coagulation profile. His current medications included hydroxyurea and penicillin prophylaxis. He underwent an urgent CT of the head followed by MRI of the brain, which revealed abnormalities as depicted in figures 1,2 edpract;103/6/290/F1F1F1Figure 1CT head. edpract;103/6/290/F2F2F2Figure 2MRI brain. QUESTION 1: Is this one of the most common neurological presentation seen in sickle cell crisis? QUESTION 2: How common is this presentation in paediatric SCD? QUESTION 3: What is the best way to manage this child?

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A review of spontaneous intracranial extradural hematoma in sickle-cell disease

Cited by 22 publications

References 38 publications

Spontaneous Subgaleal Hematoma in a Sickle Cell Disease Patient: A Case Report

Spontaneous Subgaleal Hematoma in a Sickle Cell Disease Patient: A Case Report

Acute spontaneous intracranial epidural haematoma and disseminated intravascular coagulation in a paediatric sickle cell patient

Sickle cell crisis: A crisis of a different sort?

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