A review of source separation and source localization approaches in peripheral nerves

Zariffa, José

doi:10.1109/acssc.2014.7094448

Cited by 9 publications

(10 citation statements)

References 39 publications

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“…However, current nerve-surface recordings suffer from relatively low spatial specificity. While novel nerve electrodes with multiple contacts are aimed at improving the quality and information content of the recordings ( 59 – 62 ), parallel attempts utilizing signal-processing and data-analysis methods have shown promise in achieving similar goals ( 63 , 64 ). Until now, however, linking such signals with functional sensory stimuli has been applied mainly by using muscle proprioceptive or somatosensory stimuli in larger nerves (for example sciatic and median nerves).…”

Section: Discussionmentioning

confidence: 99%

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity

Zanos

Silverman

Levy

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

160

159

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SignificanceEvolution conferred animals with molecular sensors that monitor cellular and organ function to detect changes in the environment. These activate sensory neural responses that drive the action of reflexes that maintain cellular and physiological homeostasis. Recent advances reveal that neural reflexes modulate the immune system, but it was previously unknown whether cytokine mediators of immunity mediate specific neural signals. Here we develop methods to isolate and decode specific neural signals recorded from the vagus nerve to discriminate between the cytokines IL-1β and TNF. This methodological waveform successfully detects and discriminates between specific cytokine exposures using neural signals.

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Section: Discussionmentioning

confidence: 99%

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity

Zanos

Silverman

Levy

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

160

159

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“…More recent advances are mainly associated with the FINE neural cuff electrode 41 , which constrains the nerve into a rectangular cross-section. Modeling and tank studies suggested~1 mm localization accuracy using FINE electrodes with 16 contacts around the dog sciatic nerve [42][43][44] . Repeatability of fascicle imaging with ISA is also unclear.…”

Section: Discussionmentioning

confidence: 99%

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

et al. 2020

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Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging with a resolution of <200 µm, <1 ms using a non-penetrating flexible nerve cuff electrode array. Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed tomography (microCT) and histology with fluorescent dextran tracers. With EIT, there are reproducible localized changes in tissue impedance in response to stimulation of individual fascicles (tibial, peroneal and sural). The reconstructed EIT images correspond to microCT scans and histology, with significant separation between the fascicles (p < 0.01). The mean fascicle position is identified with an accuracy of 6% of nerve diameter. This suggests fast neural EIT can reliably image the functional fascicular anatomy of the nerves and so aid selective neuromodulation.

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“…While intra-neural electroneurography (ENG) technologies, such as the UTAH slanted electrode array, can resolve multiple concurrent sites of activity in real-time, and with spatial and temporal resolutions suitable for neural prosthetics [3], they have a high risk of medical complications due to the crush and cut type injury during device insertion, and persistent inflammation from stiffness mismatch between electrodes and neural tissues [4,5]. Extra-neural ENG-technologies, on the other hand, are considered safe for chronic implantation and are compatible with real-time applications [6], but have not been shown to spatially resolve more than one [7][8][9] or two [10] concurrently active sites of neural activity, the former with nerve cuff and the latter with in flat interface nerve electrodes.…”

Section: Introductionmentioning

confidence: 99%

Extracting impedance changes from a frequency multiplexed signal during neural activity in sciatic nerve of rat: preliminary study in vitro

et al. 2019

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Objective: Establish suitable frequency spacing and demodulation steps to use when extracting impedance changes from frequency division multiplexed (FDM) carrier signals in peripheral nerve.Approach: Experiments were performed in-vitro on cadavers immediately following euthanasia. Neural activity was evoked via stimulation of nerves in the hind paw, while carrier signals were injected, and recordings obtained, with a dual ring nerve cuff implanted on the sciatic nerve. Frequency analysis of recorded compound action potentials (CAPs) and extracted impedance changes, with the latter obtained using established demodulation methods, were used to determine suitable frequency spacing of carrier signals, and bandpass filter (BPF) bandwidth and order, for a frequency multiplexed signal.Main results: CAPs and impedance changes were dominant in the frequency band 200 -500 Hz and 100 -200 Hz, respectively. A Tukey window was introduced to remove ringing from Gibbs phenomena. A +/-750 Hz BPF bandwidth was selected to encompass 99.99% of the frequency power of the impedance change. Modelling predicted a minimum BPF order of 16 for 2 kHz spacing, and 10 for 4 kHz spacing, were required to avoid ringing from the neighbouring carrier signal, while FDM experiments verified BPF orders of 12 and 8, respectively, were required. With a notch filter centred on the neighbouring signal, a BPF order of at least 6 or 4 was required for 2 and 4 kHz, respectively. Significance:The results establish drive frequency spacing and demodulation settings for use in FDM electrical impedance tomography (EIT) experiments, as well as a framework for their selection, and, for the first time, demonstrates the viability of FDM-EIT of neural activity on peripheral nerve, which will be a central aspect of future real-time neural-EIT systems and EIT-based neural prosthetics interfaces.

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A review of source separation and source localization approaches in peripheral nerves

Cited by 9 publications

References 39 publications

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

Extracting impedance changes from a frequency multiplexed signal during neural activity in sciatic nerve of rat: preliminary study in vitro

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